2007
DOI: 10.1063/1.2790370
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Magnetoimpedance biosensor for Fe3O4 nanoparticle intracellular uptake evaluation

Abstract: Iron oxide (Fe3O4) nonspecific nanoparticles of 30nm are embedded inside human embryonic kidney (HEK 293) cells by intracellular uptake with a concentration of ∼105 particles/cell. An amorphous ribbon of Co64.5Fe2.5Cr3Si15B15 exhibiting large magnetoimpedance (MI) serves as the sensing element. The presence of fringing fields of the nanoparticles changes the superposition of the constant applied field and the alternating field created by a current flowing through the ribbon that can be detected as a change in … Show more

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Cited by 72 publications
(48 citation statements)
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“…6 In recent years, the Fe 3 O 4 attracted additional attention due to the request from environmental applications in which it be used as an adsorbent due to the high adsorption capacity of magnetite MNPs for heavy metals and organic pollutants. 10 Such a result would be not possible without enormous efforts in the development of fabrication, [11][12][13][14] characterization techniques 15,16 and basic theory in the magnetism of the fine particles 17,18 and assemblies of ferromagnetic nanoparticles. 19 There are different physical and chemical methods for fabrication of the oxide MNPs: hydrothermal synthesis, 11 microemulsion, 12 chemical co-precipitation, 16,20 oxidation of Fe(OH) 2 , 21 heating the material with different types of irradiation, 22 autocombustion, 4 and biomioneralization 23 etc.…”
Section: Introductionmentioning
confidence: 99%
“…6 In recent years, the Fe 3 O 4 attracted additional attention due to the request from environmental applications in which it be used as an adsorbent due to the high adsorption capacity of magnetite MNPs for heavy metals and organic pollutants. 10 Such a result would be not possible without enormous efforts in the development of fabrication, [11][12][13][14] characterization techniques 15,16 and basic theory in the magnetism of the fine particles 17,18 and assemblies of ferromagnetic nanoparticles. 19 There are different physical and chemical methods for fabrication of the oxide MNPs: hydrothermal synthesis, 11 microemulsion, 12 chemical co-precipitation, 16,20 oxidation of Fe(OH) 2 , 21 heating the material with different types of irradiation, 22 autocombustion, 4 and biomioneralization 23 etc.…”
Section: Introductionmentioning
confidence: 99%
“…8,9 For biological applications it is important to have spherical MNPs to ensure an intracellular up-take. 2,10 Although some progress has been made in fabricating spherical MNPs, the shape is still one of the most difficult parameters to control. In addition, modern drug delivery technologies require a rather large amount of the uniform material.…”
Section: Introductionmentioning
confidence: 99%
“…Magnetoimpedance (MI) is the change of the high frequency impedance of a soft ferromagnet under application external magnetic field [1][2][3][4]. Mathematical description of the magnetoimpedance phenomenon requires analytical solution of the Maxwellґs equations that can be done only for simplest geometries and using approximations [5][6][7].…”
Section: Introductionmentioning
confidence: 99%