Magnetophoretic Decoupler: Magnetophoretic Decoupler for Disaggregation and Interparticle Distance Control (Adv. Sci. 12/2021)

Kim, Hyeonseol; Lim, Byeonghwa; Yoon, Jong–Hwan; Kim, Keonmok; Torati, Sri Ramulu; Kim, CheolGi

doi:10.1002/advs.202170070

Cited by 5 publications

(4 citation statements)

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“…In addition, to combine with existing microfabrication technologies, the micromagnet pathway could be utilized with a microcatheter to reach narrow microvascular channels for robust and precise drug delivery with organized manipulation, which enables to overcome the intrinsic limitations of tubular catheters and freely swimming microrobots. [ 29,30 ]…”

Section: Discussionmentioning

confidence: 99%

Magnetically Selective Versatile Transport of Microrobotic Carriers

Hu,

Kim,

Ali

et al. 2024

Small Methods

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Field‐driven transport systems offer great promise for use as biofunctionalized carriers in microrobotics, biomedicine, and cell delivery applications. Despite the construction of artificial microtubules using several micromagnets, which provide a promising transport pathway for the synchronous delivery of microrobotic carriers to the targeted location inside microvascular networks, the selective transport of different microrobotic carriers remains an unexplored challenge. This study demonstrated the selective manipulation and transport of microrobotics along a patterned micromagnet using applied magnetic fields. Owing to varied field strengths, the magnetic beads used as the microrobotic carriers with different sizes revealed varied locomotion, including all of them moving along the same direction, selective rotation, bidirectional locomotion, and all of them moving in a reversed direction. Furthermore, cells immobilized with magnetic beads and nanoparticles also revealed varied locomotion. It is expected that such steering strategies of microrobotic carriers can be used in microvascular channels for the targeted delivery of drugs or cells in an organized manner.

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Section: Discussionmentioning

confidence: 99%

Magnetically Selective Versatile Transport of Microrobotic Carriers

Hu,

Kim,

Ali

et al. 2024

Small Methods

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“…It combines transport lines and switching elements on a single element level. Chains of equivalent oval structures form the basic transport elements, exhibiting a rectifying unidirectional motion scheme [ 46 ] as MBs are transferred over differently curved elements, [ 39,47 ] leading to a linear bucket brigade like transport scheme where the MB transport direction is defined by the element arrangement and not the actual sequence of the applied magnetic field. Based on the resulting unidirectional particle motion, additional single magnetic elements are incorporated.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Bucket Brigade Transport Networks for Cell Transport

Block

Klingbeil

Sajjad

et al. 2023

Adv Materials Technologies

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Controlled transport of biological cells in biomedical applications such as sorting, cell sequencing, and assembly of multicellular structures is a technological challenge. Research areas such as drug delivery or tissue engineering can benefit from precise cell location resulting in faster response rates or more complex tissue structures. Using computational methods, different soft magnetic elements with curved edges are designed to form a transport network, enabling transport and all functionalities for the manipulation of microbeads and cells on surfaces by rotational magnetic fields. Building blocks with bimodal functionalities due to segments of differently curved edges permit breakpoints as well as switchable transport via splitting and combining elements. Connecting the elements, networked paths are realized which allow variable movement patterns of magnetic carriers and cells. The direction of magnetic field rotation is altered to direct the beads and cells into different transport lines, and the exact timing is not critical. The networks are used to achieve deterministic movement of microbeads and cells with minimal intervention. Programmed transport over one millimeter with cell transport velocities of several micrometers per s is demonstrated. Based on scalable microchip technology, the networks can be integrated with CMOS‐compatible materials and straightforwardly combined with sensing and diagnostic structures.

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“…[ 54–56 ] To overcome this limitation, magnetic structures that respond to external fields by generating local fields can be employed to create varied movements. [ 25,57–63 ] In other words, continuous temporal conversion of the local field through alteration of the external field can induce distinct particle movements at different locations.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Lateral Ladder for Unidirectional Transport of Microrobots: Design Principles and Potential Applications of Cells‐on‐Chip

Ali,

Kim,

Torati

et al. 2023

Small

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Functionalized microrobots, which are directionally manipulated in a controlled and precise manner for specific tasks, face challenges. However, magnetic field‐based controls constrain all microrobots to move in a coordinated manner, limiting their functions and independent behaviors. This article presents a design principle for achieving unidirectional microrobot transport using an asymmetric magnetic texture in the shape of a lateral ladder, which the authors call the “railway track.” An asymmetric magnetic energy distribution along the axis allows for the continuous movement of microrobots in a fixed direction regardless of the direction of the magnetic field rotation. The authors demonstrated precise control and simple utilization of this method. Specifically, by placing magnetic textures with different directionalities, an integrated cell/particle collector can collect microrobots distributed in a large area and move them along a complex trajectory to a predetermined location. The authors can leverage the versatile capabilities offered by this texture concept, including hierarchical isolation, switchable collection, programmable pairing, selective drug‐response test, and local fluid mixing for target objects. The results demonstrate the importance of microrobot directionality in achieving complex individual control. This novel concept represents significant advancement over conventional magnetic field‐based control technology and paves the way for further research in biofunctionalized microrobotics.

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Magnetophoretic Decoupler: Magnetophoretic Decoupler for Disaggregation and Interparticle Distance Control (Adv. Sci. 12/2021)

Cited by 5 publications

References 0 publications

Magnetically Selective Versatile Transport of Microrobotic Carriers

Magnetically Selective Versatile Transport of Microrobotic Carriers

Magnetic Bucket Brigade Transport Networks for Cell Transport

Magnetic Lateral Ladder for Unidirectional Transport of Microrobots: Design Principles and Potential Applications of Cells‐on‐Chip

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