Granular magnetic systems consisting of magnetic nanoparticles embedded in a nonmagnetic metallic matrix have emerged as an attractive building block for nanodevices. A key challenge for building interface-based nanodevice applications, such as magnetic memory devices, is to clearly know about the influences of interfacial roughness on the scattering of conduction electrons. Here, we demonstrate a granular magnetic system composed of Co and Cu nanoparticles and further link the atomic structure of the Co/Cu interface to the scattering mechanism of conduction electrons. The multiple scattering is caused by the dislocations at the rough interface, which lead to a reduction of conduction efficiency and an increase of energy consumption. These dislocations mostly originate from the lattice defects on the surface of nanoparticles, the lattice mismatch of two crystal structures, and the different surface energies. Based on the negative effects of a rough interface on electronic transport, we first develop a nanometal-fuse resistor, which could hopefully be used in the protection circuits of nanodevices. Our results may open up the possibility of implementing the low-dimensional granular magnetic materials in nanodevice applications.