Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles

He, Yuan; Zhang, Ye; Wang, Yanyun; Cui, Mengyao; Li, Galong; Liu, Xiaoli; Fan, Haiming

doi:10.1007/s11427-020-1907-6

Cited by 33 publications

(17 citation statements)

References 42 publications

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“…Interestingly, the magnetothermal effect of MIONs can also be used to enhance its intrinsic catalytic activity. Exposing MIONs to AMF was shown to effectively enhance their peroxidase nanozyme activity without changing the bulk temperature of the solution, and the degree of rate enhancement has a linear dependence on the SAR of MIONs [ 99 ]. Zhang et al studied the influence of the magnetothermal effect of MIONs on the activity of the natural enzyme glucose oxidase (GOx) [ 59 ].…”

Section: Basis Of Magnetic Nanomaterials Mediated Diagnosis and Therapy Of Cancermentioning

confidence: 99%

Design of Magnetic Nanoplatforms for Cancer Theranostics

et al. 2022

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Cancer is the top cause of death globally. Developing smart nanomedicines that are capable of diagnosis and therapy (theranostics) in one–nanoparticle systems are highly desirable for improving cancer treatment outcomes. The magnetic nanoplatforms are the ideal system for cancer theranostics, because of their diverse physiochemical properties and biological effects. In particular, a biocompatible iron oxide nanoparticle based magnetic nanoplatform can exhibit multiple magnetic–responsive behaviors under an external magnetic field and realize the integration of diagnosis (magnetic resonance imaging, ultrasonic imaging, photoacoustic imaging, etc.) and therapy (magnetic hyperthermia, photothermal therapy, controlled drug delivery and release, etc.) in vivo. Furthermore, due to considerable variation among tumors and individual patients, it is a requirement to design iron oxide nanoplatforms by the coordination of diverse functionalities for efficient and individualized theranostics. In this article, we will present an up–to–date overview on iron oxide nanoplatforms, including both iron oxide nanomaterials and those that can respond to an externally applied magnetic field, with an emphasis on their applications in cancer theranostics.

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Section: Basis Of Magnetic Nanomaterials Mediated Diagnosis and Therapy Of Cancermentioning

confidence: 99%

Design of Magnetic Nanoplatforms for Cancer Theranostics

et al. 2022

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“…Au [19][20][21][22][23][24][25][26], Pt [27], Cu [28], Ir [29], Ag [30], Au-Pt [31,32], Pd-Cu [33], Pd-Pt [34], Au-Ag [35], etc), transition metal oxide or sulfide (e.g. Fe 3 O 4 [36][37][38], CuO [39], CeO 2 [40], V 2 O 5 [41], Co-V mixed metal oxide (MMO) [42], MoS 2 [43][44][45][46][47], NiS 2 [48], CuS [49][50][51][52], Co 4 S 3 [53], MnO 2 [54] etc), and nanocarbon (e.g. boron doped graphdiyne (B-GDY) [8], N-doped sponge-like carbon spheres (N-SCSs) [55], graphene quantum dots [56,57], etc)-based nanozymes, to recentlyadvanced metal organic framework (MOF) (e.g.…”

Section: Future Perspectivesmentioning

confidence: 99%

Efficient nanozyme engineering for antibacterial therapy

et al. 2022

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Antimicrobial resistance (AMR) has posed a huge threat to human health. It is urgent to explore efficient ways to suppress the spread of AMR. Antibacterial nanozymes has become one of the powerful weapons to combat AMR due to their enzyme-like catalytic activity with a broad-spectrum antibacterial performance. However, the inherent low catalytic activity of nanozymes limits their expansion into antibacterial applications. In this regard, a variety of advanced chemical design strategies have been developed to improve the antimicrobial activity of nanozymes. In this review, we have summarized the recent progress of advanced strategies to engineering efficient nanozymes for fighting against AMR, which can be mainly classified into catalytic activity improvement, external stimuli, bacterial affinity enhancement, and multifunctional platform construction according to the basic principles of engineering efficient nanocatalysts and the mechanism of nanozyme catalysis. Moreover, the deep insights into the effects of these enhancing strategies on the nanozyme structures and properties are highlighted. Finally, current challenges and future perspectives of antibacterial nanozymes are discussed for their future clinical potential.

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“…This observation agrees with our previous report and confirms that AMF-induced heat generation can indeed amplify the nanozyme activity of the Fe 3 O 4 NR. 30 To further investigate the reason for different degrees of cascade activity enhancement for different Fe 3 O 4 NR@GOx during AMF exposure, we then monitored the evolution of the bulk H 2 O 2 concentration in these reaction solutions (Figures 3f and S9). For the reaction of the GOx and Fe 3 O 4 NR mixture, AMF exposure leads to no regulation of the bulk H 2 O 2 concentration (Figure S9a), consistent with the negligible effect of AMF exposure on the cascade activity of the GOx and Fe 3 O 4 NR mixture.…”

Section: Amf Regulation On Thementioning

confidence: 99%

“…27−29 Previously, we have shown that the nanozyme activities of iron oxide nanoparticles can be accelerated upon subjection to AMF. 30 Besides, enzymes anchored on the immediate surface of MNPs 25,31 or entrapped in MNP-loaded hydrogels 26,32 are also shown to be activated by MNPmediated heat production. Therefore, it is reasonable to speculate that magneto-heat could offer a straightforward stimulus for modulating enzyme−nanozyme cascade catalysis to benefit their biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

“…This characteristic opens up a new opportunity to impart heat-triggered control of the enzyme–nanozyme cascade reaction. As compared to light stimuli, an alternating magnetic field (AMF) can induce heat generation via Neel or Brown relaxation of the magnetic nanoparticles (MNPs), and this magnetic-field-based platform is well recognized for the advantages of good biocompatibility for in vivo applications, in-depth tissue penetration with minimal invasiveness, and capability for spatiotemporal control. − Previously, we have shown that the nanozyme activities of iron oxide nanoparticles can be accelerated upon subjection to AMF . Besides, enzymes anchored on the immediate surface of MNPs , or entrapped in MNP-loaded hydrogels , are also shown to be activated by MNP-mediated heat production.…”

Section: Introductionmentioning

confidence: 99%

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Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy

Zhang

Wang

Zhou

et al. 2021

ACS Appl. Mater. Interfaces

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Spatiotemporal regulation of multi-enzyme catalysis with stimuli is crucial in nature to meet different metabolic requirements but presents a challenge in artificial cascade systems. Here, we report a strategy for precise and tunable modulation of enzyme−nanozyme cascade reaction kinetics by remote magnetic stimulation. As a proof of concept, glucose oxidase (GOx) was immobilized onto a ferrimagnetic vortex iron oxide nanoring (Fe 3 O 4 NR) functionalized with poly(ethylene glycol) of different molecular weights to construct a series of Fe 3 O 4 NR@GOx with nanometer linking distances. The activities of GOx and the Fe 3 O 4 NR nanozyme in these systems were shown to be differentially stimulated by Fe 3 O 4 NR-mediated local heat in response to an alternating magnetic field (AMF), leading to modulated cascade reaction kinetics in a distancedependent manner. Compared to the free GOx and Fe 3 O 4 NR mixture, Fe 3 O 4 NR(D2)@GOx with an optimum linking distance of 1 nm exhibits a superior kinetic match between GOx and the Fe 3 O 4 NR nanozyme and over a 400-fold higher cascade activity under AMF exposure. This enables remarkable intracellular reactive oxygen species production and significantly improved tumor inhibition of AMF-stimulated Fe 3 O 4 NR(D2)@GOx in 4T1 tumor-bearing mice. The strategy reported here offers a straightforward new tool for fine-tuning multi-enzyme catalysis at the molecular level using magnetic stimuli and holds great promise for use in a variety of biotechnology and synthetic biology applications.

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Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme activity of iron oxide nanoparticles

Cited by 33 publications

References 42 publications

Design of Magnetic Nanoplatforms for Cancer Theranostics

Design of Magnetic Nanoplatforms for Cancer Theranostics

Efficient nanozyme engineering for antibacterial therapy

Precise Regulation of Enzyme–Nanozyme Cascade Reaction Kinetics by Magnetic Actuation toward Efficient Tumor Therapy

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