Distance correlations of Late Tortonian-Messinian littoral carbonate complexes are proposed from the study of eight platforms in the western and central Mediterranean. Correlations are based on the identification of two major biological sedimentary cycles and of two index surfaces. Surface A is a maximum flooding surface during cycle 1 at around 6.7 Ma. Surface B is a regional marine planation surface at around 5.95 Ma, at the base of cycle 2 (Terminal Carbonate Complex). A general sedimentary model is proposed for the 7-5.6-Ma time-span. The boundary between cycles 1 and 2 is coincident with the onset of the Messinian Salinity Crisis, and appears to be related to major environmental-paleooceanographic changes in the Mediterranean, rather than to a major sea-level drop or to climatic change.