Magnifying Endoscopy with Narrow Band Imaging of Early Gastric Cancer: Correlation with Histopathology and Mucin Phenotype

Ok, Kyung Sun; Kim, Gwang Ha; Park, Do Youn; Lee, Hyun Jeong; Jeon, Hye Kyung; Baek, Dong Hoon; Lee, Bong Eun; Song, Geun Am

doi:10.5009/gnl15364

Cited by 24 publications

(30 citation statements)

References 33 publications

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“…If irregular microvascular and/or microsurface patterns are observed, a diagnosis of gastric cancer can be made [34, 43]. Some studies verified that NBI microvascular and/or microsurface patterns can also predict the histologic type of early gastric cancer (differentiated or undifferentiated) [10, 34, 44, 45]. …”

Section: Stomachmentioning

confidence: 99%

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy

Barbeiro

Libânio

Castro

et al. 2018

GE Port J Gastroenterol

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Narrow-band imaging is an advanced imaging system that applies optic digital methods to enhance endoscopic images and improves visualization of the mucosal surface architecture and microvascular pattern. Narrow-band imaging use has been suggested to be an important adjunctive tool to white-light endoscopy to improve the detection of lesions in the digestive tract. Importantly, it also allows the distinction between benign and malignant lesions, targeting biopsies, prediction of the risk of invasive cancer, delimitation of resection margins, and identification of residual neoplasia in a scar. Thus, in expert hands it is a useful tool that enables the physician to decide on the best treatment (endoscopic or surgical) and management. Current evidence suggests that it should be used routinely for patients at increased risk for digestive neoplastic lesions and could become the standard of care in the near future, at least in referral centers. However, adequate training programs to promote the implementation of narrow-band imaging in daily clinical practice are needed. In this review, we summarize the current scientific evidence on the clinical usefulness of narrow-band imaging in the diagnosis and characterization of digestive tract lesions/cancers and describe the available classification systems.

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Section: Stomachmentioning

confidence: 99%

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy

Barbeiro

Libânio

Castro

et al. 2018

GE Port J Gastroenterol

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“…However, no studies have reported the difference between EGCs of the corpus and antrum under ME-NBI. The MV and MS features of EGC summarized in previous studies also cannot be used to distinguish between the different regions of antrum and corpus [13,[15][16][17][18]. We hypothesize that there may be different MV and MS patterns between EGCs of the corpus and antrum under ME-NBI.…”

Section: Introductionmentioning

confidence: 81%

“…The MV patterns were classi ed as loop, ne network, or corkscrew according to the classi cation previously reported [16] (Fig. 2).…”

Section: Me-nbimentioning

confidence: 99%

Differences in the Microsurface and Microvascular Features between Early Gastric Cancer of Corpus and Antrum under Narrow Band Imaging Magnifying Endoscopy

Zhuang

Wang

Luo

et al. 2019

Preprint

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Background Microsurface structure (MS) and microvascular features (MV) of early gastric cancer (EGC) are associated with the histologic type, invasion depth and macroscopic shape of lesions. However, no studies have reported the differences in the MS and MV features between EGCs of antrum and corpus under magnifying endoscopy with narrow band imaging (ME-NBI).Methods This was a retrospective study including 116 patients with EGC. The characteristics of MS and MV pattern of EGC were evaluated in 2 group, antrum type and corpus type.Results According to the Sakaki's classi cation, the MS of EGCs presented as IV, V1 or VI typein in sequence, one level higher than the previous type in the degree of atypia.Tumor location and differentiated degree were identi ed as independent predictors for MS pattern. For the probability of at least one level higher, in the MS pattern, the corporal EGCs was 5.84 times as high as that of antral EGCs ( χ 2 =9.42, P=0.002, 95%CI 1.89-18.05), and undifferentiated-type lesions was 8.82 times as high as that of the differentiated-type lesions ( χ 2 =11.67, P=0.001, 95%CI 2. 53-30.76). No difference in the MV pattern was observed between antral EGCs and corporal EGCs (P=0.7), while the microvascular pattern and microsurface pattern (VS pattern, FNP, ILL-1, ILL-2 and CSP) were signi cantly different between those 2 groups (P=0.001).Conclusions There are signi cant differences in the MS and VS pattern of EGC between antrum and corpus types. The antral EGC is less obvious than the corporal EGC, therefore, it is more likely to be missed in clinical gastroscopy.

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“…ME-NBI is a powerful diagnostic modality because it can enable visualization of real-time microscopic images of the mucosal surface 9 , and the most advanced endoscope has a maximal resolution power as small as 6.4 µm 10 . Although the clinical usefulness of ME-NBI has been reported in gastritis and early gastric cancer 11 12 , reports on use of ME-NBI in gastric subepithelial lesions are few. Histologically, heterotopic pancreas mainly consists of exocrine tissue and excretory ducts.…”

Section: Discussionmentioning

confidence: 99%

Magnifying endoscopy with narrow-band imaging for gastric heterotopic pancreas

Kim

Lee

et al. 2018

Endosc Int Open

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Background and study aims Heterotopic pancreas is a common subepithelial lesion in the stomach. However, its histological diagnosis is difficult when tissue samples are obtained with a conventional biopsy forceps. This study aimed to describe the magnifying endoscopy with narrow-band imaging (ME-NBI) features of gastric heterotopic pancreas. Patients and methods We retrospectively analyzed a database of all patients who underwent endoscopic ultrasonography (EUS) at Pusan National University Hospital from January 2010 to December 2010. Thirty-six patients with endosonographically diagnosed heterotopic pancreas who underwent ME-NBI and endoscopic ultrasonography (EUS) simultaneously were studied. The ME-NBI features of their lesions were analyzed. Results Thirty lesions were located in the antrum and six in the body. Six lesions (17 %) showed umbilication or central dimpling on the surface, and nine (25 %) had a macroscopic opening on the surface. On ME-NBI, a microscopic opening was identified in 22 (81 %) of 27 lesions wherein a macroscopic opening was not observed during conventional endoscopy. Macroscopic or microscopic opening was observed in 31 lesions (86 %). The frequency of macroscopic or microscopic opening was higher in lesions with anechoic duct-like structures than in lesions without such structures on EUS (91 % [29/32] vs 50 % [2/4], P = 0.027). Focal loss of microsurface structure and presence of a thickened submucosal vessel were observed in 6 (17 %) and 5 lesions (14 %), respectively. Conclusions The characteristic ME-NBI feature of heterotopic pancreas is presence of a microscopic opening on its surface. This ME-NBI feature is potentially useful for differentiating heterotopic pancreas from other gastric subepithelial tumors.

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Magnifying Endoscopy with Narrow Band Imaging of Early Gastric Cancer: Correlation with Histopathology and Mucin Phenotype

Cited by 24 publications

References 33 publications

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy

Differences in the Microsurface and Microvascular Features between Early Gastric Cancer of Corpus and Antrum under Narrow Band Imaging Magnifying Endoscopy

Magnifying endoscopy with narrow-band imaging for gastric heterotopic pancreas

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