Magnifying narrow-band imaging of surface maturation in early differentiated-type gastric cancers after Helicobacter pylori eradication

Abstract

Identification of surface maturation under NBI-ME offers a promising approach for accurate diagnosis of early gastric cancers after successful eradication.

A Comparative Study of White Light Endoscopy, Chromoendoscopy and Magnifying Endoscopy with Narrow Band Imaging in the Diagnosis of Early Gastric Cancer after Helicobacter pylori Eradication

“…All EGC lesions were histologically diagnosed as differentiated adenocarcinoma. Distinct histologic changes of gastric cancer after H. pylori eradication are characterized as either regenerating non-tumorous epithelium covering over the tumorous tissue and/or surface differentiation of tumors [8][9][10], which may influence the endoscopic or histological diagnosis using the endoscopic biopsy. We investigated these histopathological characteristics in the EGC lesions.…”

“…Location, morphology, color and depth and unexpected SM2 case were using Chi statistics. such as regenerating non-tumorous epithelium covering over the tumorous tissue and/or surface differentiation of tumors [9,10], which may confuse the endoscopic diagnosis. We investigated the association between indistinct cases of EGC lesions from the eradication group and the presence of regenerating non-tumorous epithelium and/or surface differentiation of tumors.…”

“…However, gastric cancer is discovered in patients even after successful H. pylori eradication [5]. Moreover, H. pylori eradication influences the clinicopathological features of gastric tumors, including macro-and microscopic appearances [6][7][8][9][10]. Gastric cancer found after H. pylori eradication appears with indistinct forms, such as tiny and flattened lesions [6][7][8].…”

“…Gastric cancer found after H. pylori eradication appears with indistinct forms, such as tiny and flattened lesions [6][7][8]. Histopathological findings of gastric cancer after H. pylori eradication are characterized as either regenerating non-tumorous epithelium covering over the tumorous tissue and/or surface differentiation of tumors [8][9][10], which may confuse endoscopic as well as histologic diagnosis [7,9,10]. This evidence suggests that EGC after H. pylori eradication might need alternative diagnostic strategy for the precise endoscopic diagnosis.…”

Endoscopic Detection of Gastric Carcinoma After Helicobacter pylori Eradication: More Difficult or Just Hype?

“…Hp eradication inhibits formation of intestinal-type cancer, allowing emergence of the gastric type, an additional cause of the difference in morphology between GC with Hp infection and after Hp eradication. Using magnifying endoscopy with narrow-band imaging (NBI) of GC, Kobayashi et al reported that *40 % of differentiatedtype cancers had evidence of gastritis, blurring differentiation of cancer from normal tissues [14]. For post-eradication GC, the lesions are likely to be difficult to detect endoscopically, as they are small, flattened, or depressed in shape, with whitish discoloration.…”