Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis

Bitew, Zebenay Workneh; Worku, Teshager; Alebel, Animut; Alemu, Ayinalem

doi:10.1177/2333794x20939423

Cited by 34 publications

(46 citation statements)

References 52 publications

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“…The NTDs incidence documented in our study is also higher than the report from a systematic review and meta-analysis conducted in Ethiopia (63.3 cases per 10,000 children) [14], from a three years retrospective study at two teaching hospitals in Addis Ababa with an incidence of 61 cases per 10,000 [10] and from WHO estimation of 22 per 10,000 births in Ethiopia [15], and eight African countries reported by WHO with 11.7 per 10, 000 births [6]. In Ethiopia, the prevalence of folate deficiency is 46.1%.…”

Section: Discussioncontrasting

confidence: 75%

Trend and burden of neural tube defects among cohort of pregnant women in Ethiopia: Where are we in the prevention and what is the way forward?

Berhane

Belachew

2022

PLoS ONE

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Introduction Neural tube defect is one of the top five most serious birth defects in the world. In Ethiopia an accurate estimate of the trend and burden of neural tube defects is still unknown. There hasn’t been much research done on the prevalence and trend of neural tube defects in Eastern Ethiopia. To complement previous efforts of studies, the purpose of this study is to estimate the trend and burden of neural tube defects in Eastern Ethiopia as well as to investigate the epidemiological implications of the findings. Methods A facility-based retrospective cohort study was carried out from cohort pregnant women who delivered in selected hospitals. File records of all babies who were found to have neural tube defects could be reached between 2017 and 2019. A structured checklist was used to collect data. The incidence of each case was calculated by dividing the number of cases per year by the total number of live births in each hospital. To determine the linear trend of neural tube defects over time, linear trend of Extended Mantel-Haenszel chi-square was performed. Data were presented using frequencies and percentages. Data were analyzed using SPSS for windows version 25. Results A total of 48,750 deliveries were recorded during the three years of the study considered for analyses with 522 women having neural tube defect giving an incidence rate of 107.5 per 10,000 live births in the three years. The most common types of neural tube defects found in the area were anencephaly and spina bifida accounting for 48.1% and 22.6%, respectively. The distribution of neural tube defects varied across the study hospitals, with Adama Medical College Hospital having the highest proportion (46.6%). Over half of the mothers (56.7%) live in cities. Mothers in the age group 25–34 (46.9%) and multigravida mothers had higher proportions (64.4%).of neural tube defects. None of the mothers took folic acid before conception, and only 19% took iron folic acid supplementation during their pregnancy. Conclusion and recommendation The findings showed that an increasing trend and burden of neural tube defects and preconception folic acid supplementation is insignificant in the region which showed that where we are in the prevention of neural tube defects. The finding suggests that preconception folic acid supplementation in conjunction with health care services should be considered to reduce the risk of neural tube defects in the region. Aside from that, intensive prevention efforts for long-term folate intake through dietary diversification and appropriate public health interventions are required. Furthermore, data must be properly recorded in order to address disparities in neonatal death due to neural tube defects, and the determinants of neural tube defects should be investigated using large scale prospective studies with biomarkers.

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Section: Discussioncontrasting

confidence: 75%

Trend and burden of neural tube defects among cohort of pregnant women in Ethiopia: Where are we in the prevention and what is the way forward?

Berhane

Belachew

2022

PLoS ONE

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“…This is comparable to studies in African countries by WHO, 11.7 per 10 000 births, 8 and in Ghana 44 (5.8%), Iraqi 45 (5.59%), Riyadh, Saudi Arabia 46 (1.2 per 1000), and Iran 47 (2.33 per 1000) births. However, this finding is lower than studies in the systematic review of Globe 13 (18.6 per 10 000), Ethiopia (63.3 cases per 10 000), 10 Addis Ababa, Ethiopia 3 (126 per 10 000), Brazil 11 (4.73 per 1000), and Nigeria 38,48 (2.75 per 1000) births. The possible explanation for this variation might be related to methodological and coverage gaps in data collection, 8 nutritional and socioeconomic factors, and the latter study included both live birth and stillbirth in the domains.…”

Section: Discussionmentioning

confidence: 60%

“…9 In Ethiopia, the prevalence of NTDs is 63.4 per 10 000 births, 17.3, 3.5, and 40 for anencephaly, encephalocele, and spinal Bifida cases per 10 000 births, respectively. 3,10 NTDs are important determinants of perinatal morbidity and mortality. 11 Many surviving children have multiple lifelong disabilities and face many significant impacts on physical, social, neurocognitive, emotional, self-esteem, psychological, and economic problems.…”

mentioning

confidence: 99%

Neural Tube Defects and Associated Factors among Neonates Admitted to the Neonatal Intensive Care Units in Hiwot Fana Specialized University Hospital, Harar, Ethiopia

Edris

Abdurahman

Desalew

et al. 2020

Global Pediatric Health

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Background: Neural tube defects are a major public health problem and substantially contribute to morbidity and mortality, particularly in low-income countries, including Ethiopia. There are a paucity of data on the magnitude and associated factors of neural tube defects in Ethiopia, particularly in the study setting. Objective: This study aimed to assess the magnitude of neural tube defects and associated factors among neonates admitted to the neonatal intensive care unit in Hiwot Fana Specialized University Hospital, Harar, Ethiopia. Methods: A hospital-based cross-sectional study was employed from October 2019 to January 2020. A total of 420 newborn-mother pairs were included consecutively. Data were collected using a face-to-face interviewer-administered questionnaire and clinical examination. Data were entered into Epi Data version 3.1 and analyzed using the statistical package for Social Sciences version 20.0 software. An adjusted odds ratio (AOR) with 95% confidence interval (CI) was used to identify the associated factors. A p-value <.05 was considered statistically significant. Results: The magnitude of neural tube defects was 5.71% (95% CI: 3.5-7.9). Approximately 83.5% of infants had spinal bifida and 16.5% anencephaly. In multivariable logistic regression analyses, preterm birth (32-34 weeks) (AOR= 3.84; 95% CI: 2.1,10.7), low birth weight (1000-1500 g) (AOR = 4.74; 95% CI: 1.8, 9.1), 1500-2500 g (AOR = 3.01; 95% CI: 2. 1, 13.2), maternal coffee consumption (AOR = 11.2; 95% CI: 3.1, 23.7), a history of abortion or stillbirth (AOR = 9.6; 95% CI:7.6,19.4), radiation exposure (AOR = 5.0; 95% CI:1.6,14.3), and intake of anticonvulsant drugs during pregnancy (AOR = 4.75; 95% CI: 1.5,16.2) were factors associated with neural tube defects. Conclusion: In this study, the burden of neural tube defects was 5.71% among neonates admitted to the neonatal intensive care unit, which was a public health concern. Increased attention to the monitoring of neural tube defects in eastern Ethiopia is crucial to improve birth outcomes in the study setting.

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“…Nowadays clinical interventions to be offered before conception to prevent adverse pregnancy outcomes have been identified 24 . But, the practice and implementation of preconception care are still at their initial phase 25 . Due to the low level of knowledge on PCC, its utilization is also lower 20 , 26 .…”

Section: Introductionmentioning

confidence: 99%

Knowledge of preconception care and its association with family planning utilization among women in Ethiopia: meta-analysis

Alemu

Bitew

Zeleke

et al. 2021

Sci Rep

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Preconception care (PCC) increases the chance of couple’s being healthy and having a healthier baby. It is an important strategy to prevent maternal and perinatal complications. The level of knowledge on preconception care increases its uptake. It is also considered as an input for further intervention of reduction in maternal and neonatal mortality enabling progress towards sustainable development goals (SDGs). Therefore, this systematic review and meta-analysis aimed to estimate the pooled knowledge level of PCC and its association with family planning usage among women in Ethiopia. All observational studies regardless of publication status were retrieved. Important search terms were used to search articles in Google scholar, African Journals Online, CINHAL, HINARI, Science Direct, Cochrane Library, EMBASE, and PubMed/Medline. Independent critical appraisal of retrieved studies was done using the Newcastle–Ottawa assessment checklist. The meta-analysis was conducted using STATA version 14 software. The I2 statistics were used to test heterogeneity, whereas publication bias was assessed by Begg’s and Egger’s tests. The results of the meta-analysis were explained in the Odds ratio (OR) with a 95% confidence interval (CI) and presented using forest plots. A total of seven articles were included in the current systematic review and meta-analysis. Based on the data retrieved from the articles, 35.7% of women in Ethiopia had good knowledge about preconception care. The subgroup analysis based on region revealed the lowest (22.34%) and highest (45.06%) percentage of good knowledge on preconception care among women who were living in Amhara and Oromia regions, respectively. Moreover, women who utilized family planning services were three and more times (OR 3.65 (95% CI 2.11, 6.31)) more likely to have a good level of knowledge about preconception care. One-third of Ethiopian women had good knowledge about preconception care. Family planning utilization had a positive impact on women’s knowledge of preconception care.

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Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis

Cited by 34 publications

References 52 publications

Trend and burden of neural tube defects among cohort of pregnant women in Ethiopia: Where are we in the prevention and what is the way forward?

Trend and burden of neural tube defects among cohort of pregnant women in Ethiopia: Where are we in the prevention and what is the way forward?

Neural Tube Defects and Associated Factors among Neonates Admitted to the Neonatal Intensive Care Units in Hiwot Fana Specialized University Hospital, Harar, Ethiopia

Knowledge of preconception care and its association with family planning utilization among women in Ethiopia: meta-analysis

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