Magnitude and temporal trend of acne vulgaris burden in 204 countries and territories from 1990 to 2019: an analysis from the Global Burden of Disease Study 2019*

Chen, H; Zhang, Tongchao; Yin, Xiaolin; Man, Jinyu; Yang, Xiaorong; Lü, Ming

doi:10.1111/bjd.20882

Cited by 51 publications

(34 citation statements)

References 45 publications

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“…To show the changing trends of burden, we also calculated the estimated annual percentage change (EAPC) based on ASRs due to uterine cancer from 1990 to 2019. This was estimated by a regression model fitted to the natural logarithm of the rate, namely ln(rate) = α + β *(calendar year) + ε 19–21 . EAPC was defined as 100 × (exp [ β ]−1) and the 95% confidence intervals (CIs) of EAPC were included in the fitted model as well.…”

Section: Methodsmentioning

confidence: 99%

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Spatiotemporal trends in burden of uterine cancer and its attribution to body mass index in 204 countries and territories from 1990 to 2019

Chen

Zhang

et al. 2022

Cancer Medicine

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Background Uterine cancer is one of the most common female cancers worldwide, with huge heterogeneity in morbidity and mortality. Although a high body‐mass index (BMI) has been linked to uterine cancer, systematic reports about the influence of high BMI and its temporal trends are scarce. Methods The annual morbidity, mortality, and disability‐adjusted life years (DALYs) of uterine cancer in 204 countries or territories were retrieved from the GBD 2019 study. To reflect trends in disease burden, we also calculated the estimated annual percentage change (EAPC) based on the age‐standardized rates of uterine cancer from 1990 to 2019. Results The global incident cases of uterine cancer increased 2.3 times from 187,190 in 1990 to 435,040 in 2019. Although the age‐standardized incidence rate (ASIR) of uterine cancer increased worldwide from 8.67/100,000 in 1990 to 9.99/100,000 in 2019, the age‐standardized death rate (ASDR) and DALY rate decreased during the same period. High socio‐demographic index (SDI) countries tended to have a higher ASIR than developing regions, and their increasing trend in ASIR was also more pronounced. The disease was rare before 40 years old, but its risk rose sharply among women aged 50–70. A high BMI was linked to more than one‐third of deaths from uterine cancer in 2019. Conclusions The incidence in developed areas was significantly higher than in developing areas and also increased much more rapidly. Elderly females, especially those with a high BMI, have a higher risk of uterine cancer. Therefore, more health resources may be needed to curb the rising burden in specific populations.

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Section: Methodsmentioning

confidence: 99%

“…This was estimated by a regression model fitted to the natural logarithm of the rate, namely ln(rate) = α + β *(calendar year) + ε . 19 , 20 , 21 EAPC was defined as 100 × (exp [ β ]−1) and the 95% confidence intervals (CIs) of EAPC were included in the fitted model as well.…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporal trends in burden of uterine cancer and its attribution to body mass index in 204 countries and territories from 1990 to 2019

Chen

Zhang

et al. 2022

Cancer Medicine

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“…Acne vulgaris is the most common skin disorder worldwide as estimated by global skin disease prevalence studies, 1 and it may persist into or appear during adulthood. This chronic inflammatory skin disease may affect the entire population, regardless of gender, including teenagers and adults.…”

Section: Introductionmentioning

confidence: 99%

What is new in adult acne for the last 2 years: focus on acne pathophysiology and treatments

2022

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Acne affects more than 640 million people worldwide, including about 85% of adolescents. This inflammatory dermatosis affects the entire population, from teenagers to adults, which reinforces the need to investigate it. Furthermore, in adults, acne has serious consequences, including a psychological impact, low self-esteem, social isolation, and depression. Over the last years, the understanding of acne pathophysiology has improved, mainly thanks to the identification of the pivotal role of the microbiota. The aim of this review was to screen the most recent scientific literature on adult acne and the newly tested treatments. Clinically, therapeutic innovations for the treatment of acne have been recently developed, including pre/probiotics, new molecules, and innovative formulations associated, however, with fewer side effects. Moreover, clinical trials are underway to use off-label molecules that seem to be proving their value in the fight against adult acne.

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“…Пик заболеваемости приходится на возраст 16-20 лет [12]. Вообще, в последнее десятилетие отмечается рост заболеваемости дерматозом во всем мире, особенно в странах с высоким уровнем дохода [13]. При этом число женщин, больных акне, в три раза превышает количество мужчин, но также можно говорить о том, что гендерные различия уменьшаются из-за выраженного роста заболеваемости среди взрослых мужчин.…”

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Exposome factors in the acne pathogenesis

et al. 2022

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The concept of the exposome, formulated more than fifteen years ago, is increasingly discussed in the modern scientific literature. The term “exposome” is understood as a cumulative measure of the impact of environmental factors on an individual throughout his or her life (from the prenatal period to death) and the biological response associated with it. The sum of these factors has a significant impact on the occurrence, course, and treatment efficacy of multifactorial diseases. The skin is a border organ and is constantly exposed to environmental influences, i.e., it is a target for the exposome. The influence of the latter components has been described in skin aging, atopic dermatitis, and malignant skin neoplasms. Acne is one of the most common chronic inflammatory dermatoses. Over the past decade, the worldwide increase in the incidence of acne, its early onset and a prolonged course, affecting adult men and women, has been noted. The review presents an analysis of the data on the effects of the components of the exposome – diet, medications, stress, and pollutants - on the course of acne. Particular attention is paid to the few data on the nature of interaction between the components of the exposome and the skin microbiome, which, on the one hand, is involved in the pathogenesis of dermatoses, including acne, and, on the other hand, is changed under the influence of exposome factors, acting as an intermediary between the environment and the human body. The search for environmental factors has at least two objectives: the discovery of potential pathogenetic links, the strength of their relationship with the clinical manifestations of the disease to develop new therapies aimed at new targets; and the creation and recommendation of a protective regime for factors with a proven effect on the course of the disease, for patients suffering from acne.

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Magnitude and temporal trend of acne vulgaris burden in 204 countries and territories from 1990 to 2019: an analysis from the Global Burden of Disease Study 2019*

Cited by 51 publications

References 45 publications

Spatiotemporal trends in burden of uterine cancer and its attribution to body mass index in 204 countries and territories from 1990 to 2019

Spatiotemporal trends in burden of uterine cancer and its attribution to body mass index in 204 countries and territories from 1990 to 2019

What is new in adult acne for the last 2 years: focus on acne pathophysiology and treatments

Exposome factors in the acne pathogenesis

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