Magnitude of arthropathy in patients with hemophilia: A single-center experience

Shamoon, Rawand

doi:10.4103/ijh.ijh_24_17

Cited by 7 publications

(7 citation statements)

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“…Target joint involvement and age at initial presentation were positively correlated (p-value=0.049), as seen in Table 2. In a study on patients with hemophilia A in Al-Ramadi City, conducted by AL-Zubaidy et al [10], 57.8% of the patients were less than 20 years old, similar to the results of Erbil et al [12]. A study by Lateef et al showcased that 50% of patients get diagnosed in the first year of life, similar to our results [11].…”

Section: Clinical Characteristicssupporting

confidence: 90%

“…[ 10 ], 57.8% of the patients were less than 20 years old, similar to the results of Erbil et al . [ 12 ]. A study by Lateef et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 11 ], in a study conducted in Diyala, showcased a 64% prevalence of joint affections. Other research conducted throughout Iraq had reported different figures for target joint involvement [ 7 , 12 ]. Our current study displays a 54% prevalence of target joint involvement.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological profile of hemophilia A in Karbala-Iraq

Mohammed Ali,

Hussein,

Al-Musawi

et al. 2023

JMedLife

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Hemophilia is an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) (in hemophilia A) or factor IX (FIX) (in hemophilia B) and is one of the most important hereditary conditions in Iraq. The current study tried to provide a glimpse into the epidemiological and clinical status, as well as complications and treatment used for patients with hemophilia A in Karbala, Iraq. This retrospective research was carried out by reviewing the medical records of 90 male patients diagnosed with hemophilia A registered at the Hereditary Blood Disease Center in Karbala Teaching Hospital for children in Karbala, Iraq. The data was collected from May 10, 2023, until June 15, 2023, and included age, severity, type of bleeding, therapeutic approach, chronic viral infections including hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). The median age of the patients was 15 years (18.86±14.42). In this study, one-third of patients' presentations started in the first year of life. The most common type was severe hemophilia A (factor VIII activity < 1%). Consequently, more than half of the patients were treated with factor VIII concentrate. Four patients had hepatitis C, while HIV was confirmed in one patient. The epidemiological or clinical parameters of hemophilia A patients in Karbala seem similar to those in other cities in Iraq. By considering this preliminary data, further comprehensive studies for patients with hemophilia and associated complications in other provinces or cities in Iraq are highly suggested to provide a clear perspective about the prevalence and epidemiological burdens.

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Section: Clinical Characteristicssupporting

confidence: 90%

“…[ 10 ], 57.8% of the patients were less than 20 years old, similar to the results of Erbil et al . [ 12 ]. A study by Lateef et al .…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological profile of hemophilia A in Karbala-Iraq

Mohammed Ali,

Hussein,

Al-Musawi

et al. 2023

JMedLife

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“…In our study, the mean total FISH score was 21.5, 21, and 19 in patients with mild, moderate, and severe hemophilia respectively, with an overall mean of 21.11 ± 4.5. These scores were a little bit lower than that reported by Shamoon et al [16], whose study revealed a mean FISH formild, moderate, and severe hemophilia of 29.5, 28.3, and 26, and an overall mean of 28. Additionally, Choudhary et al [17] reported higher scores than ours despite including more cases of severe disease (52%) compared to ours (28%).…”

Section: Discussioncontrasting

confidence: 69%

Assessment of quality of life by functional independence score in hemophilic patients: a single-center experience

et al. 2022

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Background Hemophilia is an inherited condition that is caused by the deficiency of clotting factors in the blood. The most common presentations of hemophilia are hemarthrosis and muscle hemorrhage. The severity of the bleeding episodes can vary from mild to severe resulting in pain and swelling of the joints and the muscles. Repeated musculoskeletal bleeding can result in hemophilic arthropathies with subsequent joint degeneration and deformity. Our study aims to clinically assess the quality of life in hemophilic patients in terms of disease severity and morbidity in our community using the Functional Independence Score for Hemophilia (FISH). Results Our cross-sectional study which involved 64 hemophilia patients revealed that the most affected joints were the weight-bearing large joints (knees, elbows, ankles) and this was associated with a lower FISH score. While the total FISH score showed a significant positive correlation with the factor activity level, the average FISH score was 21.11 ± 4.5, and the score was slightly lower in severe hemophilia compared to mild-moderate disease. Conclusion We concluded that there is a significant decline in the functional ability of hemophilia patients having disease affecting the knee and elbow joints. Moreover, squatting was significantly reduced in patients with severe hemophilia. The quality of patients’ life can be improved by early and regular physiotherapy and regular administration of the prophylactic factor.

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“…Mean FISH for mild, moderate and severe haemophilia in study done by Shamoon et al 11 was 29.5, 28.3 and 26 and overall mean was 28. Overall Mean FISH in study done by Thangamani 12 et al was 25.48.…”

Section: B a C K G R O U N D Figure 2 Discussionmentioning

confidence: 80%

Functional Independence Score in Haemophilia: A Hospital Based Observational Study in a Tertiary Care Center in Central India

Choudhary¹,

Sharma²,

Nigam³

et al. 2019

jebmh

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BACKGROUND Functional Independence Score in Haemophilia (FISH) is a performance-based assessment tool, to objectively measure the patient's functional disability. The present study was done to assess the functional abilities of haemophiliac patients presenting to a tertiary care centre. METHODS This hospital based observational study was performed on all patients (100) diagnosed as haemophilia referred to Hamidia Hospital from 1 st March 2017 to 30th June 2018. Patients with other bleeding disorders and patients on medication which can alter coagulation profile were excluded. RESULTS Mean FISH for mild, moderate and severe haemophilia was 25.26±2.62, 23.65±3.67 and 21.81±2.65 and overall mean was 23.51±3.23. CONCLUSIONS The functional components like transfer and locomotion were mainly determined by joint bleeds and total joint score respectively which were observed by the positive correlation between the respective components. Hence more the bleed and joint score, higher the dependence for transfer and locomotion.

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Magnitude of arthropathy in patients with hemophilia: A single-center experience

Cited by 7 publications

References 0 publications

Epidemiological profile of hemophilia A in Karbala-Iraq

Epidemiological profile of hemophilia A in Karbala-Iraq

Assessment of quality of life by functional independence score in hemophilic patients: a single-center experience

Functional Independence Score in Haemophilia: A Hospital Based Observational Study in a Tertiary Care Center in Central India

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