Magnitude of depression and associated factors among patients with tuberculosis in sub-Saharan Africa: A systematic review and meta-analysis.

Amha, Haile; Mulugeta, Henok; Getnet, Asmamaw; Haile, Dessalegn; Anteneh, Keralem; Tilahun, Melkamu

doi:10.1016/j.jadr.2021.100080

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…The pooled estimate prevalence of the depressive disorder in patients with tuberculosis in our systematic review and meta-analysis has a big difference when compared with the 4% prevalence, found in the general population 30 . This systematic review and meta-analysis are in line with a study by Duko B, 2020 among tuberculosis patients who had depressive disorder 45.19% 31 , but it was higher than the study done in sub-Saharan Africa pooled prevalence of depression among patients with tuberculosis was 39.42% 32 .…”

Section: Discussionsupporting

confidence: 88%

Prevalence of depression in people with tuberculosis in East Africa: a systematic review and meta-analysis

Getinet¹,

Amare²

2023

Afr H. Sci.

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Background: Depression is one of the most common mental health problems comorbid with tuberculosis. However, a consolidated picture of the prevalence of depression among tuberculosis patients in East Africa remains unknown. This systematic review and meta-analysis provide new understandings by systematically examining evidence concerning the prevalence of depression among tuberculosis patients in East Africa. Methods: Literature was found in a database of HINARI, SCOPUS, PubMed, Science Direct, and Google Scholar. The Newcastle- Ottawa quality assessment scale was used to appraise the quality of the selected studies. Then, the DerSimonian and Laird random-effects model was applied because of the presence of heterogeneity among studies. Results: A total of 409 studies were accessed. However, only 29 qualified for a full-text review, and 9 studies with a population of 2838 were included in the qualitative description and quantitative analysis. The pooled prevalence estimate of depression amongst tuberculosis patients was 43.03 % (34.93, 51.13). The highest prevalence was observed in Kenya, with 45.71% (29.26, 62.16); a similar rate was observed in Ethiopia, with 45.11 % (34.60, 55.62). Subgroup analysis based on screening tool was used: 45.71% with BDI and 41.53% with PHQ. Keywords: Depression; East Africa; meta-analysis; systematic review; TB patients.

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Section: Discussionsupporting

confidence: 88%

Prevalence of depression in people with tuberculosis in East Africa: a systematic review and meta-analysis

Getinet¹,

Amare²

2023

Afr H. Sci.

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Depression symptoms among Afghan TB patients: A multi-center study

Stanikzai,

Ishaq,

Zafar

et al. 2024

Indian Journal of Tuberculosis

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Possible depression in new tuberculosis patients in the Free State province, South Africa

Kigozi-Male,

Heunis,

Engelbrecht

et al. 2024

Southern African Journal of Infectious Diseases

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Background Despite compelling evidence of comorbidity between tuberculosis (TB) and depression, little is known about the prevalence and determinants of depression among TB patients in the Free State province in South Africa. Objectives This study assessed the prevalence and factors associated with possible depression among new drug susceptible TB patients attending primary health care facilities. Method The study followed a cross-sectional design. Trained fieldworkers conducted face-to-face interviews with conveniently selected patients. Depression was assessed using the Patient Health Questionnaire-9. Data were subjected to descriptive and binomial logistic regression analyses. Results Out of 208 patients, 46.2% screened positive for possible depression – 22.6%, 18.8%, and 4.8% presenting with mild, moderate, and severe symptoms, respectively. Possible depression odds were three times higher among females than males (adjusted odds ratio [AOR]: 3.0; 95% confidence interval [CI]: 1.25–7.32) and 2.7 times higher among extrapulmonary TB (EPTB) than pulmonary TB patients (95% CI: 1.03–7.21). Longer TB treatment duration was protective (AOR: 0.8; 95% CI: 0.70–0.95) against depression. Among human immunodeficiency virus-positive patients, those on antiretroviral therapy (ART) had 2.5 times higher odds of depression (95% CI: 1.13–5.46) than those who were not. Conclusion The results highlight a significant burden of possible depression among new TB patients, particularly among females, EPTB patients, and ART recipients. Longer TB treatment duration may offer some protection against depression symptoms, suggesting a need for enhanced adherence support. Contribution The results suggest that strengthening TB and mental health service integration is critical to improving treatment outcomes, overall well-being of TB patients, and the performance of the Free State TB programme.

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Magnitude of depression and associated factors among patients with tuberculosis in sub-Saharan Africa: A systematic review and meta-analysis.

Cited by 3 publications

References 35 publications

Prevalence of depression in people with tuberculosis in East Africa: a systematic review and meta-analysis

Prevalence of depression in people with tuberculosis in East Africa: a systematic review and meta-analysis

Depression symptoms among Afghan TB patients: A multi-center study

Possible depression in new tuberculosis patients in the Free State province, South Africa

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