Magnitude of H. pylori and Its Association with Preeclampsia Among Pregnant Women in Ethiopia: A Case Control Study

Tsegaye, Nebiyu; Diriba, Regasa; Araya, Shambel

doi:10.2147/ijwh.s363137

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…Other urine-based assays remain investigative; for instance, the urinary levels of 8-oxo-7,8-dihydro-2′deoxyguanosine (8-oxodG) were proposed to detect pregnancy conditions associated with oxidative stress, such as the diagnosis of small for gestational age (12). Stool biomarker analysis was also used to investigate the relation of H. pylori antigen and gut microbiota dysbiosis with hyperemesis gravidarum, preeclampsia, and preterm birth (13)(14)(15)(16). Although these non-invasive biomarker detection methods are currently under investigation, they have limitations such as low accuracy, low positive predictive value, low sensitivity, low specificity, and/or insufficient information for incorporation into clinical practice (9,10,15,16).…”

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confidence: 99%

The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications

Abouzaid,

Howidi,

Badran

et al. 2023

Front. Med.

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Early and minimally invasive methods are required to predict the risk of multiple adverse pregnancy outcomes. A potential technique with growing interest utilizes the gingival crevicular fluid (GCF), a physiological serum exudate found in the healthy gingival sulcus and in the periodontal pocket in inflammatory conditions. Analysis of biomarkers in the GCF is a minimally invasive method that can be feasible and cost-effective. The potential use of GCF biomarkers along with other clinical indicators in early pregnancy may provide reliable predictors of several adverse pregnancy outcomes, therefore, reducing both maternal and fetal morbidities. Various studies have reported that increased or decreased concentrations of different biomarkers in GCF are associated with a high risk of developing pregnancy complications. In particular, such associations have been commonly demonstrated with gestational diabetes, pre-eclampsia, and pre-term birth. However, limited evidence is available regarding other pregnancy complications such as preterm premature rupture of membranes, recurrent miscarriage, small for gestational age, and hyperemesis gravidarum. In this review, we discuss the reported association between individual GCF biomarkers and common pregnancy complications. Future research is required to provide more solid evidence of the predictive value of those biomarkers in estimating women’s risk for each disorder.

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Section: Introductionmentioning

confidence: 99%

The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications

Abouzaid,

Howidi,

Badran

et al. 2023

Front. Med.

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Relationship between helicobacter pylori infection and the incidence of dyslipidemia among asymptomatic adults in Jimma City, Ethiopia

Zawdie,

Abate,

Tesfaye

et al. 2024

Preprint

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Infection with H. Pylori triggers chronic inflammatory states along with dyslipidemia contribute of atherosclerosis. However, there is lack of emerging evidences of relationship of H. pylori infections and dyslipidemia among healthy adults. Therefore, this study aimed to investigate the relationship between H. pylori infection and the incidence of dyslipidemia among asymptomatic adults in Jimma City, Ethiopia. A total of 865 asymptomatic adults aged > 18 years were enrolled in the study. From each study participants, 24-hrs dietary re-call, Rome-III based criteria abdominal pain symptoms, 5ml of venous blood and 20g of fresh stool was collected. From the study participants, positive H. pylori infection was, 170(19.7%) whereas dyslipidemia incidence was, 108(12.5). Factors significantly associated with the H. pylori positive test with an AOR (95% CI, p < 0.05) were chewing khat, less physical activity, dyslipidemia, being hypertensive, central obesity and functional dyspepsia as compared to their normal counterparts. However, H. pylori infection was not associated with any of the dietary diversity scores. H. pylori infection is detected among asymptomatic population living in our study area. Moreover, H. pylori infection is significantly associated with dyslipidemia. Therefore, early screening and decreasing the risk factors are highly recommendable.

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Potential Impact of Active H. pylori Infection-Related Metabolic Syndrome on Preeclampsia Among Pregnant Women [Letter]

Tzitiridou‐Chatzopoulou¹,

Gialamprinou²,

Kountouras³

2022

IJWH

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In their case control study, Tsegaye et al 1 by introducing the stool antigen test (SAT) for the diagnosis of Helicobacter infection (Hp-I) concluded that Hp-I is linked with preeclamptic pregnant women in Ethiopia associated with metabolic syndrome (MetS) parameters such as body mass index, diabetes mellitus, dyslipidemia and arterial hypertension.Although the SAT has been introduced broadly in Africa, the limitation of this study, as also mentioned by others 2 is that only the SAT was used. By introducing several diagnostic approaches increases the detection of Hp-I. 2 Specifically, despite the advantages (easy to perform and rapid for Hp detection), SATs display several disadvantages. Because the principle of SAT is an antigen-antibody reaction, differences in antigens used for SAT in different geographic regions may cause heterogeneity of results; the diagnostic performances of different SATs are heterogeneous, and this could relate to the designs of the test like enzyme immunoassay and immunochromatographic assay (ICA) and for the selection of antibody, such as monoclonal antibody and polyclonal antibody. SAT shows a high rate of false positivity. Moreover, SAT negative results may not signify the absence of Hp-I because the low gastric colonization of bacteria results in low concentration of Hp antigen in the sample. Furthermore, concerning ICA-based methods, subjective interpretation of the results, especially for the tracing line, makes it problematic to diagnostic accuracy. The accuracy of SAT is influenced by several factors, including antibiotics, proton pump inhibitors, N-acetylcysteine, bowel movement and upper gastrointestinal tract bleeding. Preservation of the specimen, like temperature and transport time before testing, and cut-off valve also have impacts on the SAT diagnostic accuracy; if study results are not compared to the gold standard examinations for the diagnosis of active Hp-I (histology, rapid urease test, culture or urea breath test), positive or negative results are still controversial.In this regard, important to note that, only active Hp-I induces humoral and cellular immune responses that, owing to the sharing of homologous epitopes (molecular mimicry), cross-react with components of the host, thereby contributing and possibly perpetuating Hp-related systemic disorders 3,4 including preeclampsia. 5 In this respect, maternal inflammatory immune reactions appear to be involved in the pathogenesis of preeclampsia; several studies of both patients and animal models have established that changes in the immune system (cellular plus humoral immunity and/or adaptiveinnate immunity) could contribute to the pathophysiology of preeclampsia.Hp-I, a worldwide burden with a mean global prevalence of 58% and accounting of about 4.4 billion of Hp infected individuals, is also related with MetS-systemic systemic pathologies such as preeclampsia, cardio-cerebrovascular, and neurodegenerative diseases, the end outcomes of MetS; 3-5 and it appears to be a critical risk factor of MetS in pregnancy and ...

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Magnitude of H. pylori and Its Association with Preeclampsia Among Pregnant Women in Ethiopia: A Case Control Study

Cited by 3 publications

References 27 publications

The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications

The potential role of the gingival crevicular fluid biomarkers in the prediction of pregnancy complications

Relationship between helicobacter pylori infection and the incidence of dyslipidemia among asymptomatic adults in Jimma City, Ethiopia

Potential Impact of Active H. pylori Infection-Related Metabolic Syndrome on Preeclampsia Among Pregnant Women [Letter]

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