Magnitude of neurogenic tumor burden in pediatric population: A tertiary care center study

Abstract

Objective:Progress in the diagnosis and treatment of childhood neoplasm in the past few decades is one of the most gratifying achievements in the field of oncology. This study was aimed to ascertain the burden (incidence and prevalence) and histopathologic features of neurogenic tumors occurring in the pediatric population.Materials and Methods:The study evaluated a total of 492 cases of pediatric tumors over a period of 8 years from 2007 to 2015, including patients of 0–12 years of age group; attending the out-patients and in-patients Department of Pediatrics and Pediatric Surgery at Jawaharlal Nehru Medical College, AMU, Aligarh, with the complaints of tumor or tumor associated sign and symptoms. Clinical profile, hematological and histopathological examination along with immunohistochemical analysis were implicated to attain a conclusive diagnosis.Result:Out of 492 pediatric tumor cases, 255 (52%) cases were benign and 237 (48%) cases were malignant. Neurogenic tumor (brain tumors) comprised 49 (10%) of the total case, being most common malignant solid neoplasm and second most common (next to leukemia) overall malignancy, constituting 49/237 (21%) cases. Astrocytoma 22/49 (45%) cases were the most common type brain tumor followed by medulloblastoma 15/49 (31%), ependymoma 9/49 (18%), and craniopharyngioma 3/49 (6%).Conclusion:Effective management of pediatric neurogenic tumor is a multipronged approach involving effort of good Pediatric neurosurgeon, Pathologist and a host of Oncology specialists with insight into childhood neoplasms.

Midline Astrocytic Tumors in Children: A Retrospective Study of 152 Cases

“…Most of the previous study had reported infratentorial region as the commonest site for pediatric astrocytic tumors. 5 However, few studies are consistent with our study and had reported that supratentorial region predominate slightly for these astrocytic tumors in children. 6 Most of the studies had reported that cerebellum was the commonest site for these tumors, which is also consistent with our study.…”

Spectrum of Infratentorial Paediatric CNS tumors in a tertiary care hospital

“…In this study, embryonal tumors are the most common histology type, followed by astrocytomas, schwannomas, and least common type is of mixed gliomas and ependymomas. Prevalence of Medulloblastoma is similar to that observation by Jain et al 2011 and Qadri et al, 2017 [8,12] where its account for more than 30%. Of these medulloblastoma cases, males (n=8) are more predominant than females (n=3) (table 2).…”

“…Under this histological type, pilocytic astrocytoma was commonly followed by diffuse astrocytoma. Our results are comparable to [12,14], except anaplastic Astrocytomas. Astrocytomas were common in females (n=6) than males (n=2).…”

Erratum: Magnitude of neurogenic tumor burden in pediatric population: a tertiary care centre study’

“…In the article titled ‘Magnitude of Neurogenic tumor burden in Pediatric population: A Tertiary Care Centre Study’ published in the pages 222-226, Issue 3, Volume 12 (July-Sept 2017), of Journal of pediatric Neurosciences[ 1 ], the name of fourth Author: Rana K Sherwani, Professor D/O Pathology, Jawaharlal Nehru Medical College, is to be included as it was missed during submission of the article, although the author has a significant contribution in the study.…”