Magnitude of uncontrolled seizures and associated factors among people with epilepsy. Data from a major teaching hospital in Southwest Ethiopia

Babu, Yadeta; Sheleme, Tadesse; Sefera, Birbirsa; Bekele, Firomsa; Olika, Wayessa

doi:10.1016/j.yebeh.2023.109089

Cited by 3 publications

(6 citation statements)

References 34 publications

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“…18-3.19). This finding is supported by the various literature across the globe 5,7,45 . The probable justification for this factor may be due to the negative effect of ADR on adherence that affects the seizure control status.…”

Section: Discussionsupporting

confidence: 87%

“…This finding was augmented by the prior reports from (ASMH) and UoGRH 25 , 35 , but it is in contrast to the other finding from Tertiary Care Hospital of India, where 42.5% of ADR were related to valproate 33 . The probable justifications for this disagreement could be in resource-poor settings like Ethiopia it is old-generation ASDs like phenobarbital and phenytoin that were frequently used in the management of epilepsy 5 .…”

Section: Discussionmentioning

confidence: 99%

“…This is 10 items self-reported Likert scale, which are further categorized as the medication necessity scale and medication concern scale, each containing five items. The patient’s belief was considered to be positive when the average sum of the 5-item patient’s medication necessity scale score exceeded the average 5-item medication concern scale, if not it was considered negative 5 . Three pharmacists, a bachelor of degree holders were participated in the overall data collection processes.…”

Section: Methodsmentioning

confidence: 99%

“…In Life time one in 26 people develop epilepsy, and it is the fourth most common neurological disorder in the world 3 . Worldwide there are seventy million people with epilepsy, and 90% of people with epilepsy live in low- and middle-income countries 4 , 5 . Epileptic seizure has a lot of negative consequences on the patient’s psychology and social life such as education, relationships, and employment status 6 .…”

Section: Introductionmentioning

confidence: 99%

“…with epilepsy live in low-and middle-income countries 4,5 . Epileptic seizure has a lot of negative consequences on the patient's psychology and social life such as education, relationships, and employment status 6 .…”

mentioning

confidence: 99%

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Antiseizure adverse drug reaction and associated factors among epileptic patients at Jimma Medical Center: a prospective observational study

Bayane,

Jifar,

Berhanu

et al. 2024

Sci Rep

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A growing body of evidence suggests that adverse drug reactions (ADRs) are a major cause of morbidity and mortality in the healthcare system. Fifteen to twenty-five percent of patients with epilepsy discontinued antiseizure drugs (ASDs) within 6 months of therapy owing to intolerable adverse drug reactions. In Ethiopia, the prevalence of antiseizure adverse drug reactions and associated factors was not extensively conducted in advanced settings like Jimma Medical Centers. Hence, the objective of this study is to assess patterns of adverse drug reactions and associated factors among ambulatory epileptic patients at tertiary hospitals in Ethiopia. A hospital-based prospective observational study was spanned for 1 year. Two hundred ninety patients were consecutively recruited into the study from all epileptic patients attending the ambulatory clinic. Relevant data were collected through patient interviews and medical chart reviews. The causality assessment was done by using the Naranjo Probability Scale. Epi-Data manager version 4.6.0.4 was used for data entry and statistical analysis was performed by Statistical Package for Social Science version 25.0 (SPSS). Stepwise backward logistic regression analysis was done to identify factors that increase the risk of antiseizure adverse drug reactions. The mean (± SD) age of the participants were 29.91(± 11.26) years. The overall prevalence of ADR was 33.8% (95% CI 29.2–39.9%). A total of 110 adverse drug reactions were identified among 98 patients with an average of 1.12 per patient. ADRs were frequently reported with phenobarbital (52.04%) and phenytoin (34.70%). The commonly identified adverse drug reactions were epigastric pain (27.55%) and central nervous system drowsiness (23.46%). Comorbidity (AOR = 5.91, 95% CI (2.14–16.32), seizure-free period of fewer than 2 years (AOR = 1.94, 95% CI (1.18–3.19), and polytherapy (AOR = 1.35, 95% CI (1.80–2.26) were significantly associated with adverse drug reactions. This trial had a comparatively high percentage of adverse medication reactions. Adverse medication reactions were more common in patients with polytherapy, comorbidities, and seizure-free durations less than two years. Therefore, medical practitioners should advise patients who exhibit these traits on how to reduce or avoid bad drug responses or provide comfort in the event of small incidents.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Antiseizure adverse drug reaction and associated factors among epileptic patients at Jimma Medical Center: a prospective observational study

Bayane,

Jifar,

Berhanu

et al. 2024

Sci Rep

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Quality of care and associated factors among patients with epilepsy at public hospitals in Arba Minch Town: a facility-based cross-sectional study

Nigatu,

Endashaw,

Sorato

et al. 2024

BMC Neurol

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Background Epilepsy is one of the most common neurologic disorders affecting approximately 51 million people globally and is associated with significant cases of age-standardized DALYs (182.6 per 100 000 people). The quality of health care services offered to people suffering from epilepsy often fails to meet standards in Ethiopia or internationally. This study was designed to assess the quality of care and associated factors among patients with epilepsy at public hospitals in Arba Minch Town, 2024. Method A facility-based cross-sectional study was conducted among 392 adult epileptic patients attending public hospitals in Arba Minch Town. Data entry was performed via Epi-data 3.1 software, and the data were analyzed via SPSS version 24 software. Binary logistic regression analysis was used to evaluate the associations between quality of care and sociodemographic, disease-related, and treatment-related factors. Multivariate logistic regression analysis was applied to identify factors independently associated with quality of care. Results Three hundred ninety-two adults with epilepsy participated in this study, for a response rate of 92.7%. More than one-half of the 237 (60.5%) patients were males, with a median age of 31 ± 12 years (interquartile range). Fewer than one-half (44.1%) of the patients adhered to antiepileptic medicines. The overall proportion of patients receiving quality care was 213 (54.3%). The seizure control rate was also low, at 130 (33.2%). Patients aged 18–29 years [AOR = 30.8 (95% CI, 8.22–35.616, p < 0.000)] and aged 30–39 years [AOR = 18.4 (95% CI, 5.016–67.613, p < 0.000)], and a seizure frequency of less than three [AOR = 2.318 (95% CI, 1.028–5.225, p < 0.043)] were positively associated with quality of care. Whereas, having poor knowledge about epilepsy [AOR = 0.107 (95% CI, 0.0.057–0.202, p < 0.000)] was negatively associated with quality care. Conclusion The quality of care provided to adult epilepsy patients at Arba Minch was low. In addition, patient knowledge, medication adherence, and the seizure control rate were also suboptimal. Therefore, addressing identified factors by involving all relevant stakeholders (health professionals, hospitals, zonal health departments, regional health bureaus, and patients) is critical for improving the quality of care. In addition, researchers willing to study this topic should use strong designs that can determine causal determinants of quality care.

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Video-Based Directly Observed Therapy (ViDOT) as a strategic tool to improve medication adherence in epilepsy: A narrative review

Olowoyo,

Oguntiloye,

Ogunjimi

et al. 2024

NRE

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BACKGROUND: The prevalence of epilepsy is highest in the Central Africa subregion most especially in rural settlements. This is further compounded by a high prevalence of treatment gap, from poor drug adherence, and poor road network. One approach to overcoming this burden is to leverage Video-based Directly Observed Therapy (ViDOT) use for stable patients living with epilepsy, harnessing the advancement in mHealth technologies, and widespread adoption of smartphones. ViDOT is a form of telemedicine that is a smartphone-based, treatment approach for monitoring and evaluating remote patients. OBJECTIVE: We performed a narrative review of the existing literature using electronic databases from PubMed and Google Scholar to identify relevant publications related to ViDOT and chronic diseases, in particular epilepsy. METHODS: The selected articles were assessed for relevance, and key findings were synthesized to provide an overview of the role of ViDOT in addressing the challenges of drug adherence in epilepsy. RESULTS: The review shows that poor drug adherence is a major risk for poor outcomes in patients living with epilepsy. ViDOT has the potential to significantly contribute to improved drug adherence in patients living with epilepsy. Other benefits of ViDOT include the elimination of prolonged waiting times, improvement in access to specialized care, eradication of self-induced stigma and discrimination, diminishing neurologists’ workload, and cost-effectiveness. Challenges include poor network coverage and unstable internet service. CONCLUSION: Giving a brief psychoeducation about epilepsy, anti-epileptic drug (AED) side effects, and the importance of sticking with the recommended drug use can improve AED adherence and epilepsy outcomes. Information dissemination through ViDOT to people with epilepsy and their caregivers at large is important to promote a healthy life.

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Magnitude of uncontrolled seizures and associated factors among people with epilepsy. Data from a major teaching hospital in Southwest Ethiopia

Cited by 3 publications

References 34 publications

Antiseizure adverse drug reaction and associated factors among epileptic patients at Jimma Medical Center: a prospective observational study

Antiseizure adverse drug reaction and associated factors among epileptic patients at Jimma Medical Center: a prospective observational study

Quality of care and associated factors among patients with epilepsy at public hospitals in Arba Minch Town: a facility-based cross-sectional study

Video-Based Directly Observed Therapy (ViDOT) as a strategic tool to improve medication adherence in epilepsy: A narrative review

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