Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors

Zaninetti, M.; Blanchet, Christophe; Tribollet, Eliane; Bertrand, Daniel; Raggenbass, Mario

doi:10.1016/s0306-4522(99)00477-7

Cited by 26 publications

(22 citation statements)

References 25 publications

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“…In addition to influencing specific cortical areas, the adrenergic/cholinergic link in the BF may participate in autonomic control by modulating hypothalamic neuroendocrine and autonomic networks. Several experiments in the rat have provided evidence for cholinergic influence on osmosensitive neurons and vasopressin release in the hypothalamic paraventricular and supraoptic nuclei (Akaishi and Negoro, 1983; Mason, 1985; Michels et al, 1986; Ota et al, 1992; Okuda et al, 1993; Shioda et al, 1997; Qadri et al, 1998; Zaninetti et al, 2000) and on body temperature and water intake regulation in the preoptic‐anterior hypothalamic areas (Takahashi et al, 2001) and in the lateral hypothalamus (Puig de Parada et al, 1997). Although the source of cholinergic input to these neuroendocrine and autonomic networks remains to be elucidated (Sawchenko and Swanson, 1983; Rao et al, 1987; Grove, 1988; Jhamandas et al, 1989; Ruggiero et al, 1990), it is likely that at least a proportion of this input originates as collaterals of BF cholinergic neurons that receive PNMT innervation.…”

Section: Discussionmentioning

confidence: 99%

Direct catecholaminergic–cholinergic interactions in the basal forebrain. III. Adrenergic innervation of choline acetyltransferase‐containing neurons in the rat

Hajszán

Záborszky

2002

J of Comparative Neurology

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The central adrenergic neurons have been suggested to play a role in the regulation of arousal and in the neuronal control of the cardiovascular system. To provide morphological evidence that these functions could be mediated via the basal forebrain, we performed correlated light and electron microscopic double-immunolabeling experiments using antibodies against phenylethanolamine N-methyltransferase (PNMT) and choline acetyltransferase, the synthesizing enzymes for adrenaline and acetylcholine, respectively. Most adrenergic/cholinergic appositions were located in the horizontal limb of diagonal band of Broca, within the substantia innominata, and in a narrow band bordering the substantia innominata and the globus pallidus. Quantitative analysis indicated that cholinergic neurons of the substantia innominata receive significantly higher numbers of adrenergic appositions than cholinergic cells in the rest of the basal forebrain. In the majority of cases, the ultrastructural analysis revealed axodendritic asymmetric synapses. By comparing the number and distribution of dopamine beta-hydroxylase (DBH)/cholinergic appositions, described earlier, with those of PNMT/cholinergic interactions in the basal forebrain, it can be concluded that a significant proportion of putative DBH/cholinergic contacts may represent adrenergic input. Our results support the hypothesis that the adrenergic/cholinergic link in the basal forebrain may represent a critical component of a central network coordinating autonomic regulation with cortical activation.

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Section: Discussionmentioning

confidence: 99%

Direct catecholaminergic–cholinergic interactions in the basal forebrain. III. Adrenergic innervation of choline acetyltransferase‐containing neurons in the rat

Hajszán

Záborszky

2002

J of Comparative Neurology

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“…Central cholinergic pathways have profound effects on rhythmic neuronal activity in a number of systems. For example, in the mammalian hippocampus (Cobb et al, 1999), supraoptic nucleus (Zaninetti et al, 1999), somatosensory cortex (Buhl et al, 1998) and entorhinal cortex (Klink and Alonso, 1997), ACh can initiate burst-mode activity and promote synchrony within neuronal populations. Furthermore, mammalian osmoregulatory vasopressin neurons, which have comparable activity patterns to bursting Dahlgren cells (Armstrong et al, 1994), are stimulated via both nicotinic and muscarinic pathways.…”

Section: Discussionmentioning

confidence: 99%

Electrical activity of caudal neurosecretory neurons in seawater- and freshwater-adapted flounder: responses to cholinergic agonists

Brierley

Ashworth

Craven

et al. 2003

Journal of Experimental Biology

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SUMMARY The caudal neurosecretory system (CNSS) of the euryhaline flounder is involved in osmoregulatory responses underlying adaptation to seawater and freshwater. This study compared electrophysiological activity and responses to cholinergic agonists in the neuroendocrine Dahlgren cells in an in vitro preparation taken from fully seawater- (SWA) or freshwater-adapted(FWA) fish. Resting membrane and action potential parameters showed few differences between SWA and FWA cells. The hyperpolarisation-activated sag potential and depolarising afterpotential were present under both conditions;however, amplitude of the latter was significantly greater in SWA cells. The proportions of cells within the population exhibiting different firing patterns were similar in both adaptation states. However, bursting parameters were more variable in FWA cells, suggesting that bursting activity was less robust. The muscarinic agonist, oxotremorine, was largely inhibitory in Dahlgren cells, but increased activity in a non-Dahlgren cell population,α neurons. Nicotine promoted bursting activity in SWA Dahlgren cells,whereas it inhibited over half of FWA cells.

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“…Although perinuclear inputs are generally regarded as being principally glutamatergic or GABAergic, a large proportion of neurones in the perinuclear zone of the SON also synthesise acetylcholine . SON MNCs express nicotinic receptors that mediate synaptic activation by perinuclear zone stimulation in vitro and central administration of the muscarinic receptor agonist, carbachol, markedly increases the firing rate of both oxytocin and vasopressin MNCs in the SON . It is likely that PVN MNCs are similarly innervated because they are directly excited via nicotinic receptors in vitro .…”

Section: Afferent Inputs To Mncsmentioning

confidence: 99%

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

Brown

Bains

Ludwig

et al. 2013

J Neuroendocrinology

146

133

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The hypothalamic supraoptic and paraventricular nucleus contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the anti-diuretic hormone) into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. While it has long been known that the activity of MNCs depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the MNCs themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity.

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Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors

Cited by 26 publications

References 25 publications

Direct catecholaminergic–cholinergic interactions in the basal forebrain. III. Adrenergic innervation of choline acetyltransferase‐containing neurons in the rat

Direct catecholaminergic–cholinergic interactions in the basal forebrain. III. Adrenergic innervation of choline acetyltransferase‐containing neurons in the rat

Electrical activity of caudal neurosecretory neurons in seawater- and freshwater-adapted flounder: responses to cholinergic agonists

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

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