Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine

Chen, Jiann-Hwa; Kuo, Hsing Chun; Lee, Kam Fai; Tsai, Tung Hu

doi:10.1016/j.taap.2014.07.005

Cited by 47 publications

(28 citation statements)

References 44 publications

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“…ROS constitute the most important factor for oxidative stress, and the major source of ROS is NADPH oxidase [54], which has been a potential target for the treatment of stroke [55]. Downregulation of nitrotyrosine protected neurons against ischemia injury [56]. Three days of EA treatment at LR3 could decrease the BP by 15 mmHg compared to the SHR and SHR + sham groups [57].…”

Section: The Potential Of Acupuncture For Secondary Prevention Of Strmentioning

confidence: 99%

Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

Zheng¹,

Han²,

Du³

et al. 2018

Complement Med Res

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Worldwide, stroke is the leading cause of mortality and disability, with hypertension being an independent risk factor for a secondary stroke. Acupuncture for the treatment of hypertension gains more attention in alternative and complementary medicine, but the results are inconsistent. Few studies regarding the secondary prevention of stroke by managing hypertension with acupuncture have been carried out as there are some problems regarding the antihypertensive drug status in the secondary prevention of stroke. Still, the potential of acupuncture in regulating the blood pressure for secondary stroke prevention deserves our focus. This review is based on papers recorded in the PubMed, Embase, and Web of Science databases, from their inception until March 28, 2017, and retrieved with the following search terms: hypertension and acupuncture, limited in spontaneously hypertensive rats (SHRs), stress-induced (or cold-induced) hypertensive or pre-hypertensive models. We find that, in these hypertensive animals, acupuncture could mainly influence factors related to the nervous system, oxidative stress, the endocrine system, cardiovascular function, and hemorheology, which are closely associated with the stroke outcome. This trend may give us a hint that acupuncture might well participate in the secondary prevention of stroke through these pathways when used in the management of hypertension.

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Section: The Potential Of Acupuncture For Secondary Prevention Of Strmentioning

confidence: 99%

Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

Zheng¹,

Han²,

Du³

et al. 2018

Complement Med Res

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“…Furthermore, magnolol enhances BDNF expression levels in the serotonergic system in the brains of rats that have been subjected to unpredictable chronic mild stress [ 171 ]. Magnolol also attenuates IL-1 β , TNF- α , IL-6, and ROS production and upregulates AKT and NF- κ B levels in the ischemia reperfusion occlusion brain injury model [ 172 ]. Additionally, honokiol treatment reversed the neuronal death and dysfunction caused by traumatic brain injury-induced apoptosis by increasing the expression of cell cycle-related proteins, including cyclin D1, CDK4, pRb, and E2F1 [ 173 ].…”

Section: Role Of Dietary Phytochemicalsmentioning

confidence: 99%

Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

Venkatesan

Kim

2015

BioMed Research International

150

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Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors. Neurotrophins such as BDNF, NGF, NT3, and NT4/5 play a vital role in neuronal and nonneuronal responses to AD. Neurotrophins depletion accelerates the progression of AD and therefore, replacing such neurotrophins may be a potential treatment for neurodegenerative disease. Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75NTR superfamily. We focus on representative phenolic derivatives, iridoid glycosides, terpenoids, alkaloids, and steroidal saponins as regulators of neurotrophin-mediated neuroprotection. Although these phytochemicals have attracted attention owing to their in vitro neurotrophin potentiating activity, their in vivo and clinical efficacy trials has yet to be established. Therefore, further research is necessary to prove the neuroprotective effects in preclinical models and in humans.

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“…Magnolol, a multifunctional component derived from Chinese herb Magnolia officinalis, has been shown to possess anti-viral, anti-inflammatory, anti-microbial, cardiovascular and neuroprotective effects (12,13). Magnolol-induced apoptosis in different types of cancer cells, including lung, colon, and prostate cancer cells was also presented (14).…”

mentioning

confidence: 99%

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells

Kuan

Chen

et al. 2018

In Vivo

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Background/Aim: The aim of the present study was to evaluate the anti-cancer effect of magnolol in hepatocellular carcinoma (HCC) cells in vitro. Materials and Methods: HCC SK-Hep1 cells were treated with different concentrations of magnolol or PD98059 [extracellular-signal-regulated kinase (ERK) inhibitor] for 48 h, and then cell viability, apoptosis, signal transduction, expression of anti-apoptotic and metastasis-related proteins, and cell invasion were investigated by [3][4]-2,5-diphenyltetrazolium bromide] (MTT) assay, flow cytometry, nuclear factor kappa B (NF-ĸB) reporter gene, western blotting, and cell invasion assays. Results: Magnolol significantly induced accumulation of sub-G 1 phase and caspase-3 activation and inhibited NF-ĸB activation, cell invasion, expression of phosphorylated ERK (pERK), anti-apoptotic and metastatic-related proteins. ERK inactivation was required for magnolol-induced inhibition of metastatic potential of SK-Hep1 cells. Conclusion: Taken together, these results indicated that magnolol not only induced apoptosis, but also inhibited ERK-modulated metastatic potential of HCC SK-Hep1 cells.

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Magnolol protects neurons against ischemia injury via the downregulation of p38/MAPK, CHOP and nitrotyrosine

Cited by 47 publications

References 44 publications

Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

Regulation of Hypertension for Secondary Prevention of Stroke: The Possible ‘Bridging Function' of Acupuncture

Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells

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