Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction

Suh, Kwang Sik; Chon, Suk; Jung, Woon‐Won; Choi, Eun Mi

doi:10.1016/j.cbi.2017.09.014

Cited by 27 publications

(25 citation statements)

References 60 publications

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“…For instance, sciadopitysin protects against MG-induced cell damage by increasing Glo-1 activity [11]. Enhanced activity is also observed in RIN-5F cells treated with MG and magnolol [37]. Consistent with these studies, we observed a significant decrease in Glo-1 activity and GSH level in INS-1 cells exposed to MG.…”

Section: Discussionsupporting

confidence: 89%

Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

2020

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Recently, the mechanisms responsible for anti-glycation activity of cyanidin and its derivatives on the inhibition of methylglyoxal (MG)-induced protein glycation and advanced glycation-end products (AGEs) as well as oxidative DNA damage were reported. In this study, we investigated the protective effect of cyanidin against MG-induced oxidative stress and apoptosis in rat INS-1 pancreatic β-cells. Exposure of cells to cytotoxic levels of MG (500 µM) for 12 h caused a significant reduction in cell viability. However, the pretreatment of cells with cyanidin alone (6.25–100 μM) for 12 h, or cotreatment of cells with cyanidin (3.13–100 μM) and MG, protected against cell cytotoxicity. In the cotreatment condition, cyanidin (33.3 and 100 μM) also decreased MG-induced apoptosis as determined by caspase-3 activity. Furthermore, INS-1 cells treated with MG increased the generation of reactive oxygen species (ROS) during a 6 h exposure. The MG-induced increase in ROS production was inhibited by cyanidin (33.3 and 100 μM) after 3 h stimulation. Furthermore, MG diminished the activity of glyoxalase 1 (Glo-1) and its gene expression as well as the level of total glutathione. In contrast, cyanidin reversed the inhibitory effect of MG on Glo-1 activity and glutathione levels. Interestingly, cyanidin alone was capable of increasing Glo-1 activity and glutathione levels without affecting Glo-1 mRNA expression. These findings suggest that cyanidin exerts a protective effect against MG-induced oxidative stress and apoptosis in pancreatic β-cells by increasing the activity of Glo-1.

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Section: Discussionsupporting

confidence: 89%

Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

2020

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“…Low-dose MG (0.01-1 μM) inhibited the death of RIN-m5F cells and the decrease of insulin secretion induced by methylglyoxal, thereby exerting hypoglycemic activity (Suh et al, 2017). It could upregulate the expression of Ins2 and PDX1, the levels of SIRT1 and PGC1α, AMPK phosphorylation, and glyoxalase 1 activity.…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

“…Type 2 diabetes, formerly known as adult-onset diabetes, mostly occurs after 35-40 years of age and accounts for more than 90% of diabetic patients (Maddaloni et al, 2020). Numerous studies have reported that MG exhibits the hypoglycemic activity and protein tyrosine phosphatase 1B (PTP1B) inhibition by mediating AMPK/silent information regulator 1 (SIRT1)/PGC-1α, PPAR-γ, and protein kinase A (PKA) pathways, enhancing the activities of glyoxalase 1, PDX1, Ins2, and GPX genes, stimulating Akt phosphorylation, and inhibiting α-glucosidase (Choi et al, 2012;Wang HY et al, 2013;Onoda et al, 2016;Pulvirenti et al, 2017;Suh et al, 2017;Parray et al, 2018).…”

Section: Hypoglycemic Activitymentioning

confidence: 99%

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Yong

Zeng

et al. 2021

Front. Pharmacol.

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Magnolol (MG) is one of the primary active components of Magnoliae officinalis cortex, which has been widely used in traditional Chinese and Japanese herbal medicine and possesses a wide range of pharmacological activities. In recent years, attention has been drawn to this component due to its potential as an anti-inflammatory and antitumor drug. To summarize the new biological and pharmacological data on MG, we screened the literature from January 2011 to October 2020. In this review, we provide an actualization of already known anti-inflammatory, cardiovascular protection, antiangiogenesis, antidiabetes, hypoglycemic, antioxidation, neuroprotection, gastrointestinal protection, and antibacterial activities of MG. Besides, results from studies on antitumor activity are presented. We also summarized the molecular mechanisms, toxicity, bioavailability, and formulations of MG. Therefore, we provide a valid cognition of MG.

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“…It is believed that it is responsible for the reduction of the mass of pancreatic islet β cells and progressive process of their destruction in the course of diabetes. Pancreatic β cells are extremely sensitive to ROS [ 34 , 35 , 36 ]. It is proven that the increased concentration of MGO results in the excessive production of ROS in the body.…”

Section: Magnolol In Diabetes and Its Complicationsmentioning

confidence: 99%

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review

Szałabska-Rąpała

Borymska

Kaczmarczyk-Sedlak

2021

IJMS

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Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate, protein, and lipid metabolism, often accompanied by oxidative stress. Diabetes treatment is a complicated process in which, in addition to the standard pharmacological action, it is necessary to append a comprehensive approach. Introducing the aspect of non-pharmacological treatment of diabetes allows one to alleviate its many adverse complications. Therefore, it seems important to look for substances that, when included in the daily diet, can improve diabetic parameters. Magnolol, a polyphenolic compound found in magnolia bark, is known for its health-promoting activities and multidirectional beneficial effects on the body. Accordingly, the goal of this review is to systematize the available scientific literature on its beneficial effects on type 2 diabetes and its complications. Taking the above into consideration, the article collects data on the favorable effects of magnolol on parameters related to glycemia, lipid metabolism, or oxidative stress in the course of diabetes. After careful analysis of many scientific articles, it can be concluded that this lignan is a promising agent supporting the conventional therapies with antidiabetic drugs in order to manage diabetes and diabetes-related diseases.

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Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction

Cited by 27 publications

References 60 publications

Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

Cyanidin Attenuates Methylglyoxal-Induced Oxidative Stress and Apoptosis in INS-1 Pancreatic β-Cells by Increasing Glyoxalase-1 Activity

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update

Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review

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