MagPure chip: an immunomagnetic-based microfluidic device for high purification of circulating tumor cells from liquid biopsies

Descamps, Lucie; Garcia, Jessica; Barthelemy, David; Laurenceau, Emmanuelle; Payen, Léa; Roy, Damien Le; Deman, Anne-Laure

doi:10.1039/d2lc00443g

Cited by 16 publications

(12 citation statements)

References 75 publications

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“…The work shown in Figure 3D purified circulating tumor cells by capturing white blood cells using magnetic traps. 74 This negative separation method does not require labeling circulating tumor cells or exposing them to magnetic fluids that may damage cell activity. Therefore, this is a highly biocompatible separation strategy.…”

Section: Magnetic Separationmentioning

confidence: 99%

Biological particle separation techniques based on microfluidics

Wang,

Xu,

Cai

et al. 2024

Interdisciplinary Medicine

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Biological particle separation has wide applications in medical diagnosis, bioengineering, and various other domains. Traditional methods, such as filtration, density gradient centrifugation, and size exclusion chromatography, face many challenges, including low separation resolution, low purity, and the inability to be seamlessly integrated into continuous processes. The development of microfluidics has paved the way for efficient and precise biological particle separation. Microfluidic chip‐based methods can generally be performed continuously and automatically, and microfluidic chips can integrate multilevel operations, including mixing, separation, detection, and so forth, thereby achieving continuous processing of particles at various levels. This review comprehensively investigates biological particle separation techniques based on microfluidic chips. According to the different sources of force effect on the particles during the separation process, they can be divided into active separation, passive separation, and affinity separation. We introduce the principles and device design of these methods respectively, and compare their advantages and disadvantages. For the introduction of each method, we used the most classic and latest research cases as much as possible. Additionally, we discussed the differences between experimental standard particles and biological particles. Finally, we summarized the current limitations and challenges of existing microfluidic separation techniques, while exploring future trends and prospects.

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Section: Magnetic Separationmentioning

confidence: 99%

Biological particle separation techniques based on microfluidics

Wang,

Xu,

Cai

et al. 2024

Interdisciplinary Medicine

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“…Combining polymer-based microfluidic devices with microscale magnetic sources has shown promise for various applications. One approach that has gained attention is using magnetic composite polymers created by a polymer matrix doped with magnetic particles or filaments to impart magnetic features [ 69 , 70 ]. Incorporating magnetic materials into polymer-based microfluidic devices is made possible and cost-effective through this method, offering promising potential.…”

Section: Application Of Polymers In Liquid Biopsy-based Diagnosismentioning

confidence: 99%

Design of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsies

et al. 2023

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Minimally invasive approaches for cancer diagnosis are an integral step in the quest to improve cancer survival. Liquid biopsies such as blood samples are matrices explored to extract valuable information about the tumor and its state through various indicators, such as proteins, peptides, tumor DNA, or circulating tumor cells. Although these markers are scarce, making their isolation and detection in complex matrices challenging, the development in polymer chemistry producing interesting structures, including molecularly imprinted polymers, branched polymers, nanopolymer composites, and hybrids, allowed the development of enhanced platforms with impressive performance for liquid biopsies analysis. This review describes the latest advances and developments in polymer synthesis and their application for minimally invasive cancer diagnosis. The polymer structures improve the operational performances of biosensors through various processes, such as increased affinity for enhanced sensitivity, improved binding, and avoidance of non-specific interactions for enhanced specificity. Furthermore, polymer-based materials can be a tremendous help in signal amplification of usually low-concentrated targets in the sample. The pros and cons of these materials, how the synthesis process affects their performance, and the device applications for liquid biopsies diagnosis will be critically reviewed to show the essentiality of this technology in oncology and clinical biomedicine.

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“…These materials also find utility in biomedical fields, where magnetic soft sensors and drug delivery systems have been developed [89,90]. Furthermore, the tunable magnetic properties of such materials facilitate precise control over fluid flows in microfluidic devices, enabling enhanced lab-on-a-chip technologies [91]. With their versatility and multifunctionality, hMSMs hold promise for enormous advances across various fields, making them an area of growing research interest within the materials community [92].…”

Section: Introductionmentioning

confidence: 99%

Hard magnetics and soft materials—a synergy

Narayanan,

Pramanik,

Arockiarajan

2024

Smart Mater. Struct.

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Hard-magnetic soft materials (hMSMs) are smart composites that consist of a mechanically soft polymer matrix impregnated with mechanically hard magnetic filler particles. This dual-phase composition renders them with exceptional magneto-mechanical properties that allow them to undergo large reversible deformations under the influence of external magnetic fields. Over the last decade, hMSMs have found extensive applications in soft robotics, adaptive structures, and biomedical devices. However, despite their widespread utility, they pose considerable challenges in fabrication and magneto-mechanical characterization owing to their multi-phase nature, miniature length scales, and nonlinear material behavior. Although noteworthy attempts have been made to understand their coupled nature, the rudimentary concepts of inter-phase interactions that give rise to their mechanical nonlinearity remain insufficiently understood, and this impedes their further advancements. This holistic review addresses these standalone concepts and bridges the gaps by providing a thorough examination of their myriad fabrication techniques, applications, and experimental, and modeling approaches. Specifically, the review presents a wide spectrum of fabrication techniques, ranging from traditional molding to cutting-edge four-dimensional (4D) printing, and their unbounded prospects in diverse fields of research. The review covers various modeling approaches, including continuum mechanical frameworks encompassing phenomenological and homogenization models, as well as microstructural models. Additionally, it addresses emerging techniques like machine learning-based modeling in the context of hMSMs. Finally, the expansive landscape of these promising material systems is provided for a better understanding and prospective research.

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MagPure chip: an immunomagnetic-based microfluidic device for high purification of circulating tumor cells from liquid biopsies

Abstract: The isolation of circulating tumor cells (CTCs) directly from blood, as a liquid biopsy, could lead to a paradigm shift in cancer clinical care by providing an earlier diagnosis, a...

Cited by 16 publications

References 75 publications

Biological particle separation techniques based on microfluidics

Biological particle separation techniques based on microfluidics

Design of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsies

Hard magnetics and soft materials—a synergy

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