Mahonia aquifolium in patients with psoriasis vulgaris — an intraindividual study

Wiesenauer, M.; Lüdtke, Rainer

doi:10.1016/s0944-7113(96)80058-4

Cited by 25 publications

(36 citation statements)

References 8 publications

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“…[12][13][14][15][16][17][18][19][20][21][22] The 12 studies were conducted in China (3), Germany (2), the U.S.A. After removing duplicates, the remaining 1614 records were screened and the full texts of 1139 articles were retrieved.…”

Section: Resultsmentioning

confidence: 99%

“…[13][14][15][16]19,20 Two studies specified the area of skin involvement, 17,18 one included 54% severe cases 22 and two studies did not specify severity. 15 Outcome measures included clinical efficacy (n = 8), [15][16][17][18][19][20][21][22] symptom score (n = 6), [14][15][16][17][18]20 Psoriasis Area and Severity Index (PASI) score (n = 7), [13][14][15][16][18][19][20] Dermatology Life Quality Index (DLQI) score (n = 2) 15,16 and Quality of Life Index (QLI) scores (n = 1). Nine studies compared a topical plant extract with a topical placebo and three studies used a topical pharmaceutical as comparator, including dithranol, 12 calcipotriol plus fluticasone propionate 16 and triamcinolone acetonide.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies stated the method of sequence generation and were assessed as 'low' risk on this item. 12,17,21 These were judged as 'high' risk, and two studies that did not provide details on blinding 18,22 were judged as 'unclear'. Three studies provided the allocation concealment method 15,17,19 and were evaluated as 'low' risk while the others were judged as 'unclear'.…”

Section: Methodological Assessmentmentioning

confidence: 99%

“…22 Augustin et al 12 compared Mahonia aquifolium ointment with dithranol using a half-body RCT to assess effects on cellular cutaneous immune mechanisms and on hyperproliferation of keratinocytes (keratin 6, keratin 15, Ki-67), adhesion molecules (intercellular adhesion molecule-1) and other activation markers [human leucocyte antigen (HLA)-DR] based on blinded assessment of biopsy results pre-and postintervention by two independent physicians. The two preparations were applied to symmetrically distributed lesions.…”

Section: Mahonia Aquifoliummentioning

confidence: 99%

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Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis

et al. 2013

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Patients with psoriasis frequently use preparations of plant extracts. Physicians need to be aware of the current evidence concerning these products. This review evaluates the efficacy and safety of preparations of plant extracts used topically for psoriasis. Searches were conducted in PubMed, Embase, the Cochrane library, two Chinese databases and article reference lists. Randomized controlled trials investigating extracts of single plants were included. Preparations of multiple plants and combinations of plant extracts plus conventional therapies were excluded. Two authors conducted searches, extracted data and assessed risk of bias. Outcomes used in meta-analyses were: clinical efficacy, Psoriasis Area and Severity Index score, and quality of life and symptom scores. The 12 included studies investigated extracts of: Mahonia aquifolium (n = 5), Aloe vera (n = 3), indigo naturalis (n = 2), kukui nut oil (n = 1) and Camptotheca acuminata nut (n = 1). Methodological quality was variable. Six studies provided data suitable for meta-analysis of clinical efficacy, and five were vs. placebo (relative risk 3·37, 95% confidence interval 1·36-8·33). Experimental studies indicate components of indigo naturalis, Mahonia and Camptotheca have anti-inflammatory, antiproliferative and other actions of relevance to psoriasis. The clinical trial evidence provides limited support for preparations containing extracts of M. aquifolium, indigo naturalis and Aloe vera for the topical management of plaque psoriasis based on multiple studies. No serious adverse events were reported. Because of the small size of most studies and methodological weaknesses, strong conclusions cannot be made. The magnitudes of any effects cannot be measured with accuracy, so it is difficult to assess the clinical relevance of these preparations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodological Assessmentmentioning

confidence: 99%

Section: Mahonia Aquifoliummentioning

confidence: 99%

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Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis

et al. 2013

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“…Clinical data reported by Bernstein et al (2006), Gulliver and Donsky (2005) and Wiesenauer and Ludtke (1996) show promising results in psoriasis cases for topical formulations (Mahonia aquifolium ointments or creams) compared to placebo or to classic therapeutic options (corticoids, vitamin D derivatives). Preparations of Mahonia were well tolerated, with rare side effects including rash, a burning sensation when applied and staining of clothes.…”

mentioning

confidence: 94%

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

Boca

Tătaru

Pincelli

et al. 2014

Not Bot Hort Agrobot Cluj

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Psoriasis is a chronic inflammatory skin disease, with an important impact on the patient's quality of life. Its incidence and prevalence are continuously increasing. The complex ethiopathology of this disorder is only partially known; there is a clear genetic predisposition, which associates a number of environmental triggering factors such as an unbalanced diet and lifestyle. The conventional therapeutic options are not always satisfactory in terms of efficiency and safety, therefore, complementary and alternative medicine approaches are frequently chosen by patients, mostly as self-medication. This review, based on recent literature flow data, outlines the pharmacological benefits of herbal formulations with antipsoriatic activity. It also reveals the molecules responsible for their effects, as well as their interference with the metabolic and immunopathogenic mechanisms of this disease. An important number of plants have been proved to act as antipsoriatic agents, many botanical-based preparations containing keyphytochemical molecules (belonging mainly to phenolics, triterpenoids and phytosterols or unsaturated fatty acids, as mentioned in specific phyto-pharmaceutical databases). Specific mechanisms of action, which can explain their activity (such as lipoxygenase inhibition, antioxidant, anti-inflammatory, anti prostaglandin), were recently described. Only some of these formulations have been actively tested in vitro or in vivo. Most publications in the field agree on the need for more in vitro and in vivo studies, especially clinical assessment on patients with Psoriasis vulgaris. These would provide more accurate data on the efficacy and safety of such herbal formulations for this disease.

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Potential herbal constituents for psoriasis treatment as protective and effective therapy

Dabholkar

Rapalli

Singhvi

2020

Phytotherapy Research

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Psoriasis is a multifactorial and chronic skin disorder. It is a recurrent disease that requires incessant therapy. Psoriasis treatment includes topical and systemic routes using synthetic drugs that lead to severe unwanted adverse effects. Herbal therapy is widely used for thousands of years in countries like China and India. The use of herbal therapy in the developed region enhanced to a great extent and showed better efficacy towards psoriasis alone or as adjuvant to synthetic therapy. Herbal medicines have gained great attention in the treatment of psoriasis due to their lesser side effects compared to synthetic drugs. In this review, the various plant sources which have been found effective in psoriasis and can be used to develop novel therapeutics have been discussed. The mechanisms by which the phytoconstituents elicit antipsoriatic activity and various research studies that have proven the effectiveness of these natural products have also been compiled in this review.

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Mahonia aquifolium in patients with psoriasis vulgaris — an intraindividual study

Cited by 25 publications

References 8 publications

Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis

Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

Potential herbal constituents for psoriasis treatment as protective and effective therapy

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