Maillard-Type Cross-Linked Soy Protein Hydrogels as Devices for the Release of Ionic Compounds: An In Vitro Study

Caillard, Romain; Mateescu, Mircea Alexandru; Subirade, Muriel

doi:10.1016/j.foodres.2010.08.001

Cited by 21 publications

(12 citation statements)

References 39 publications

(58 reference statements)

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“…Also, by varying the extent of crosslinking, the swelling of the hydrogels and subsequently the release rate of cargo from the gels could be controlled [374]. Glutaraldehyde crosslinked soy protein hydrogels were developed, and their potential for in vitro releasing of the ionic compounds (amaranth and methylene blue) was investigated [321,375]. It has been shown that increasing the extent of crosslinking and the salt concentration during gel preparation led to a decrease in the rate of swelling/release rates regardless of using a digestive enzyme.…”

Section: Plant Protein-based Hydrogels For Drug Deliverymentioning

confidence: 99%

Status and future scope of plant-based green hydrogels in biomedical engineering

Mohammadinejad

Maleki

Larrañeta

et al. 2019

Applied Materials Today

189

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Hydrogels are the most iconic class of soft materials and since their first report in the literature has attracted the attention of uncountable researchers. Over the past two decades, hydrogels become smart and sophisticated materials with plenty of applications possibilities. The biomedical research area has demonstrated a particular interest in hydrogels since they can be engineered from different polymers and due to their tunable properties. Moreover, hydrogels engineered from polymers extracted from biorenewable sources have been popularized in biomedical usages, as they are low-toxic, eco-friendly, biocompatible, easily accessible, and inexpensive at the same time. However, the multifaceted challenge is to find an ideal plant green hydrogel in the tissue engineering that can mimic critical properties of human tissues in terms of structure, function, and performance. In addition, these natural polymers are also idealized to be conveniently functionalized so that their chemical and physical behaviour can be manipulated for drug delivery and stem cell-guided tissue regeneration. Here, the most recent advances in the synthesis, fabrication and application of plant green hydrogels in biomedical engineering are reviewed. It covers essential and updated information about plant as green sources of biopolymers to be used in hydrogel synthesis, general aspects of hydrogels and plant green hydrogels and a substantive discussion regarding the use of such hydrogels in the biomedical engineering area. Furthermore, this review addresses and detail the present status of the field and, also, answer several important questions about the potential use of plant green hydrogels in advanced biomedical applications including therapeutic, tissue engineering, wound dressing, diagnostic, etc.

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Section: Plant Protein-based Hydrogels For Drug Deliverymentioning

confidence: 99%

Status and future scope of plant-based green hydrogels in biomedical engineering

Mohammadinejad

Maleki

Larrañeta

et al. 2019

Applied Materials Today

189

View full text Add to dashboard Cite

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“…In the presence of pepsin at pH 1.2, both the hydrogels provided good protection of riboflavin for at least 6 h and the release of riboflavin was independent of time or concentration (zero-order release), while the gels were digested in the presence of pancreatin at pH 7.5. 136 These findings demonstrated the properties of the loaded compounds also affected their release behaviour in hydrogels. 135,136 Increasing the cross-linking extent and the concentration of salt in the gel generally led to the decrease of swelling/release rates without digestive enzyme.…”

Section: Hydrogelsmentioning

confidence: 85%

“…126 flavin due to their lower porosity when compared to the particulate hydrogels. 135,136 Increasing the cross-linking extent and the concentration of salt in the gel generally led to the decrease of swelling/release rates without digestive enzyme. 133,134 In other studies, soy protein hydrogels cross-linked by glutaraldehyde were studied in vitro for their potential as devices for the release of ionic compounds (amaranth and methylene blue).…”

Section: Hydrogelsmentioning

confidence: 99%

Plant protein-based delivery systems for bioactive ingredients in foods

2015

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The application of food-grade delivery systems for the encapsulation, protection and controlled release of bioactive food ingredients have recently gained increasing interest in the research fields of functional foods and pharmaceutics. Plant proteins (mainly soy proteins, zein and wheat gliadins), which are widely available and environmentally economic compared to animal derived proteins, can be made into various delivery platforms, such as micro- and nanoparticles, fibers, films and hydrogels. In this paper, we review the recent progress in the preparation of food-grade delivery systems based on plant proteins for bioactive ingredients, and highlight some of the challenges and directions that will be the focus of future research. The preparation and application of bifunctional particles, which were able to deliver the bioactives to oil/water interface and stabilize the interface, are also described, providing a novel perspective for the design of plant protein-based delivery system.

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“…3 Common methods to induce gelling include thermal treatment, salt-driven cold setting, pressure application, and chemical and enzymatic crosslinking. 4…”

Section: Introductionmentioning

confidence: 99%

“…In addition to specific tissue engineering applications, the use of soy hydrogels may be an ideal carrier for drug delivery applications since SPI has been known to form stable networks in the presence of other ionic compounds and in varying pH solutions, presenting opportunities for controlled release. 1,11,12 Soy protein has been previously reported to provide sustained release of model nutrients such as riboflavin and isoflavones, 1,13,14 model drugs and dyes such as amaranth, methylene blue, and rifampicin, 4,15 and proteins such as bovine serum albumin. 16,17…”

Section: Introductionmentioning

confidence: 99%

Investigation of soy protein hydrogels for biomedical applications: Materials characterization, drug release, and biocompatibility

2013

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Soy protein is emerging as a novel material for biomedical applications due to its abundance in nature, ease of isolation and processing, and inherent properties for mediating cell adhesion and growth. In this study, mechanically robust soy protein hydrogels were fabricated with varying weight percentages in water (15, 18, and 20 wt.%) without the use of chemical modifiers or crosslinkers. This fabrication method is beneficial because it allows for the direct injection of these soy hydrogels in vivo. The material properties, drug releasing capability, and biocompatibility in vitro and in vivo were assessed. The different concentrations of soy protein varied the rheological, swelling, and mechanical properties and affected the release of the model drug fluorescein from the hydrogels in vitro. Higher weight percent of soy increased the robustness of the hydrogels and released a lower amount of fluorescein over one week. Viability and growth of seeded L929 mouse fibroblasts demonstrated that the hydrogels were biocompatible in vitro for one week. Soy hydrogels were injectable in vivo into the subcutaneous pocket of mice, and histological staining showed minimal fibrous capsule formation for up to 20 days. The ease of fabrication and tailorable properties of soy hydrogels render it a promising biomaterial for tissue engineering and drug delivery applications, particularly for wound healing.

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Maillard-Type Cross-Linked Soy Protein Hydrogels as Devices for the Release of Ionic Compounds: An In Vitro Study

Cited by 21 publications

References 39 publications

Status and future scope of plant-based green hydrogels in biomedical engineering

Status and future scope of plant-based green hydrogels in biomedical engineering

Plant protein-based delivery systems for bioactive ingredients in foods

Investigation of soy protein hydrogels for biomedical applications: Materials characterization, drug release, and biocompatibility

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