2020
DOI: 10.1016/j.eurpolymj.2020.110079
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Main-chain water-soluble polyphosphoesters: Multi-functional polymers as degradable PEG-alternatives for biomedical applications

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Cited by 70 publications
(74 citation statements)
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“…However, low biodegradability of PEG causes formation of PEG antibodies, emergence of hypersensitivity, etc. [ 5 ]. In some experiments with subcutaneous injection of PEGylated implants, the formation of fibrous capsule was detected [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
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“…However, low biodegradability of PEG causes formation of PEG antibodies, emergence of hypersensitivity, etc. [ 5 ]. In some experiments with subcutaneous injection of PEGylated implants, the formation of fibrous capsule was detected [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Ethylene phosphates, phosphonates and phosphoramidates with short alkyl substituents ( Scheme 1 a) represent promising cyclic substrates for the synthesis of copolymers with hydrophilic biodegradable blocks using catalytic ring-opening polymerization (ROP, Scheme 1 b) [ 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. 2-Ethoxy-1,3,2-dioxaphospholane 2-oxide (ethyl ethylene phosphate, EtOEP) is one of the most reliable monomers for the preparation of hydrophilic polyphosphoesters (PPEs) due to high reactivity and low tendency to form branched polymers [ 15 , 16 , 17 ].…”
Section: Introductionmentioning
confidence: 99%
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“…The fragments of poly(ethylene glycol) (PEG)—a hydrophilic polymer improving solubility and acting as a transporter—are widely used in development of such scaffolds. A promising alternative to PEG is comprised by poly(ethylene phosphates) (PEPs), which are structurally similar to the phosphoester backbone of polynucleic acids: chemically versatile, biocompatible, and biodegradable; those properties allow the development of tailored materials suitable for different uses, including as polymers for biomedical applications [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. PEP is usually prepared by the catalytic ring-opening polymerization (ROP) of cyclic ethylene phosphate monomers (CEPMs) ( Scheme 1 a).…”
Section: Introductionmentioning
confidence: 99%
“…Copolymers of poly(ethylene phosphoric acid)s (PEPA) that can be obtained by different methods [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], are polyacids potentially able to bind and deliver organic bases, including drugs. Despite the obvious promise of PEPA for different biomedical applications [ 27 , 36 , 37 , 39 , 40 , 41 , 42 , 43 , 44 ], the ability of PEPA-containing polymers to act as a carrier of antiviral drugs with basic functional groups have not been studied to date.…”
Section: Introductionmentioning
confidence: 99%