Approximately 50% of the adult global population is projected to suffer from some
form of metabolic disease by 2050, including metabolic syndrome and diabetes mellitus. At the
same time, this trend indicates a potential increase in the number of patients who will be in need
of implant-supported reconstructions of specific bone regions subjected to inflammatory states.
Moreover, physiological conditions associated with dysmetabolic subjects have been suggested
to contribute to the severity of bone loss after bone implant insertion. However, there is a perspective evidence strengthening the hypothesis that custom-fabricated bioengineered scaffolds
may produce favorable bone healing effects in case of altered endocrine or metabolic conditions. This perspective review aims to share a comprehensive knowledge of the mechanisms
implicated in bone resorption and remodelling processes, which have driven researchers to develop metallic implants as the cobalt-chromium (Co-Cr) bioscaffolds, presenting optimized geometries that interact in an effective way with the osteogenetic precursor cells, especially in the
cases of perturbed endocrine or metabolic conditions.