Evapotranspiration (ET) is vital for the Earth's energy and water balance, particularly influenced by global climate change. The Yunnan-Guizhou Plateau (YGP), characterized by abundant water resources and intricate terrain, has been a subject of study. However, previous research often overlooked intra-annual climate variations in ET. This study employed high-spatiotemporal resolution ET data from 2003 to 2020 to quantitatively analyze the spatiotemporal characteristics of ET on the YGP. The annual ET showed an increasing trend of 0.18 mm/year, with monthly ET increases in January, March, November, and December, mainly influenced by vegetation transpiration, which accounts for 56% of ET. Breakpoints in ET trends and seasonal components occurred in January 2007 and June 2018. The geodetector model assessed the impact of 15 driving factors on ET, with net radiation and vegetation index playing dominant roles with q-values of 0.29 and 0.24. Factor impacts varied seasonally, with greater influence in the dry season (q-value of 0.53 for net radiation in January) and lesser in the rainy season (q-value of 0.08 in August). Pearson correlation analysis indicated that different driving factors influenced ET in different months. These findings enhance understanding of plateau ET responses to climate change mechanisms.