Mains-powered hypoxic gas generation: a cost-effective and safe method to evaluate patients at risk from hypoxia during air travel

Dye-free retinal angiography using blood-oxygenation modulation

“…In our study, subjects inhaled a single deep breath of a 5% O2, 95% N2 gas mixture and held their breath for 15 seconds, producing an average maximal decrease in fingertip arterial OS of 12%. This transient hypoxia is similar in magnitude to the mild hypoxia that is generally considered safe in other realms, such as the sustained ~10% decrease in OS experienced during plane travel [49][50][51][52] or up to 20% OS used in various scientific studies. [30,53,54] No adverse effects were reported by the healthy subjects from the protocol we employed here.…”

Effect of acute systemic hypoxia on human cutaneous microcirculation and endothelial, sympathetic and myogenic activity

“…Analysis of HRV measurements were conducted with the aid of Kubios HRV Analysis Software 2.1 (MATLAB, the Biomedical Signal Analysis Group, University of Kuopio, Kuopio, Finland) and data interpretation was M A N U S C R I P T ACCEPTED MANUSCRIPT made on basis of previous researches (Huang et al 2009;Wang & Huang 2012). To simulate systemic hypoxia (normobaric hypoxia), a hypoxicator (GO2Altidude, Biomedtech, Melbourne, Australia) which has an air separation system employing semi-permeable membrane technology (Spurling et al, 2011) was used, continuously pumping air at a flow rate of 20 l*min −1 into an air bag which was connected to a facial mask to deliver lower atmospheric O 2 concentration to the subjects (GO2Altitude, Biomedtech, Melbourne, Australia). Gas concentrations in the bag (oxygen mixture at 12%) were monitored by an oxygen sensor (Cambridge Sensotec, Cambs, UK).…”

Effect of Short Systemic Intermittent Hypoxia on Systemic Hemodynamics Blunted in Cutaneous Microcirculation

“…Analysis of HRV measurements were conducted with the Kubios HRV Analysis Software 2.1 (MATLAB, the Biomedical Signal Analysis Group, University of Kuopio, Kuopio, Finland). To simulate systemic hypoxia (normobaric hypoxia) a hypoxicator (GO2Altidude, Biomedtech, Melbourne, Australia) which has an air separation system employing semi-permeable membrane technology [21] was used, continuously pumping air at a flow rate of 20 l*min−1 into an air bag which was connected to a facial mask to deliver lower atmospheric O 2 concentration to the subjects (GO2Altitude, Biomedtech, Melbourne, Australia). Gas concentrations in the bag (oxygen mixture at 12%) were monitored by an oxygen sensor (Cambridge Sensotec, Cambs, UK).…”