Maintenance chrysotherapy in rheumatoid arthritis: a comparison of 2 dose schedules.

Griffin, Audrey; Gibson, T.; Huston, G.; Taylor, Andrew

doi:10.1136/ard.40.3.250

Cited by 17 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a paucity of studies that examine the role of maintenance therapy with gold. One study found no advantage of fortnightly over monthly maintenance injections in terms of efficacy, but the fortnightly group had more toxicity [26]. Another randomized subjects to maintenance therapy of 100 mg fortnightly with aurothioglucose or placebo and found no differences between subjects at 12 months [27].…”

Section: Maintenance Therapymentioning

confidence: 99%

Injectable Gold Compounds: An Overview

Jones¹,

Brooks²

1995

Rheumatology

View full text Add to dashboard Cite

Injectable gold compounds have enjoyed widespread, but occasionally controversial, use in rheumatoid arthritis since the 1920s. This overview examines the data from controlled trials and longer-term observational studies. We conclude that gold is equivalent to other widely used second-line agents in terms of efficacy. Toxicity profiles are similar, apart from methotrexate. It is most efficacious and toxic in the first 2 yr of treatment. There appears to be a dose-response relationship for both efficacy and toxicity. Gold is one of the few agents that decreases the rate of progression of erosions (RR 0.38, 95% CI 0.23-064). Gold compounds, therefore, have a definite place in the rheumatologist's armamentarium, but further research is required to determine optimal monitoring regimes as well as the role of maintenance therapy and combination therapy.

show abstract

Section: Maintenance Therapymentioning

confidence: 99%

Injectable Gold Compounds: An Overview

Jones¹,

Brooks²

1995

Rheumatology

View full text Add to dashboard Cite

show abstract

“…Radiographic scoring methods have been used in a number of clinical studies as one measure of drug effectiveness (8,18,24,32,38,(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57). There is convincing evidence that gold salts and high-dose steroid treatment can slow the progression of radiologic abnormalities.…”

Section: Radiologic Scoring In Clinical Trialsmentioning

confidence: 99%

Radiologic assessment as an outcome measure in rheumatoid arthritis

Jt¹

1989

Arthritis & Rheumatism

104

View full text Add to dashboard Cite

“…When gold salts are used in medicine as pharmacotherapy, the use of gold salts is referred to as 'Chrysotherapy' and/or 'Aurotherapy' [7][8][9][10]. Pure metallic gold does not undergo chemical, mechanical, electrochemical, and/or mechanic-chemical unless the metal is in a chemical molecular salt form [7][8][9][10].…”

Section: Gold Use In Medicinementioning

confidence: 99%

Gold in Medicine and Dentistry

Touyz,

Touyz

2023

DOHC

View full text Add to dashboard Cite

Provenance: Gold as a precious metal is well-known and is enmeshed in many cultural heritages. Besides being used for centuries for jewelry, it was co-opted as coinage. as building material and used in dentistry and medicine. Aim: This article appraises salient gold characteristics. Reviewed here are (1) gold properties, (2) Human gold physiology, (3) Gold’s current use in medicine, (4) Gold’s nutritional value, and (5) Gold use in dentistry. Conclusion: Although gold is found in miniscule amounts in the body and has slight anti-inflammatory effects as a salt, gold is still cherished as jewelry, remains chemically inert, is used in dentistry and medicine, has minimal nutritional value, and has scant metabolic function in humans.

show abstract

Maintenance chrysotherapy in rheumatoid arthritis: a comparison of 2 dose schedules.

Cited by 17 publications

References 14 publications

Injectable Gold Compounds: An Overview

Injectable Gold Compounds: An Overview

Radiologic assessment as an outcome measure in rheumatoid arthritis

Gold in Medicine and Dentistry

Contact Info

Product

Resources

About