Maintenance of bone mass by physical exercise after discontinuation of intermittent hPTH(1–34) administration

Yamamoto, Noriaki; Takahashi, Hideaki; Tanizawa, Tatsuhiko; Fujimoto, Ryuhei; Hara, Toshiaki; Tanaka, Sakura

doi:10.1016/s0169-6009(08)80107-9

Cited by 34 publications

(18 citation statements)

References 33 publications

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“…It has been documented that weight-bearing bones like the tibia and femur have higher sensitivity to treadmill exercise than less weight-bearing bones like the lumbar spine in rats [10,12,14,27], and the efficacy of treadmill exercise in terms of weight-bearing activity of long bones has been demonstrated in a variety of rat models, i.e., young female rats (Iwamoto et al [14]), young male rats (Bourrin et al [4]), ovariectomized rats (Barengolts et al [2], Yeh et al [28]), adult female rats (Yeh et al [16]), rats with kidney disease (Darnley et al [6]), heavy ion particle irradiated rats (Fukuda et al [8]), rats taking caffeine (Huang et al [9]), rats with bone loss caused by immobilization (Kannus et al [15]), rats consuming alcohol (Reed et al [18]), orchidectomized rats (Tuukkanen et al [19]), and rats discontinuing parathyroid hormone (PTH) administration (Yamamoto et al [20]). In this paper, we review the effects of treadmill exercise on bone mass, bone metabolism, and/or bone strength of the appendicular long bones and axial bones in young, adult, ovariectomized, and osteopenic female rats.…”

Section: Introductionmentioning

confidence: 99%

Effect of Treadmill Exercise on Bone Mass in Female Rats

2005

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Section: Introductionmentioning

confidence: 99%

Effect of Treadmill Exercise on Bone Mass in Female Rats

2005

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“…The stiffness measurements from each group were similar to the load measurements. when the bone mass has returned to a point where fracture risk that the newly gained bone mass would be lost if the treatment is substantially reduced or where treatment has to be disconwas not continued (35,36,46). The idea of using an antitinued for any reason, we have studied the efficacy of using resorptive agent to preserve the bone gained from the use of estrogen alone to maintain the increased bone mass.…”

Section: Introductionmentioning

confidence: 99%

“…Jee and his present study, we have employed an animal model of postmenocolleagues demonstrated that one can preserve PGE2-induced pausal osteoporosis in a "crossover" study to determine bone gain by administering risedronate (23,24). Physical exerwhether estrogen treatment alone can maintain improvements cise (46) and pamidronate (47) were shown to maintain PTHin bone mass and microarchitecture and whether this anabolic stimulated increases in bone mass in ovariectomized rats after It is shown at statistical significant with P value set at 0.05 in the Duncan's multiple range test of the ANOVA. a, P < 0.05 for Cn-BV/TV; b, P < 0.05 for Th.Th; c, P < 0.05 for Nd.Nd; d, P < 0.05 for BMD at distal femur.…”

Section: Introductionmentioning

confidence: 99%

Effects of reciprocal treatment with estrogen and estrogen plus parathyroid hormone on bone structure and strength in ovariectomized rats.

Shen¹,

Birchman²,

Xu³

et al. 1995

J. Clin. Invest.

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Intermittent administration of PTH has been found to be an effective anabolic agent in cancellous bone. We have reported previously that combined treatment with PTH and estrogen in estrogen-deficient rats was beneficial in correcting established osteopenia. To determine if the beneficial effects of PTH therapy can be preserved by estrogen alone and whether PTH therapy can be effective in treating osteopenic subjects stabilized with estrogen, we have undertaken a "crossover" study in the rat model of estrogendeficiency induced osteopenia. Six-month-old female rats were ovariectomized and after 5 wk treated for 8 wk with vehicle, 30 rig/kg per day of rPTH(1-34) plus 15 ,.g/kg per day of 17fi-estradiol or 17f3-estradiol alone. One group from each treatment regimen was then sacrificed and for an additional 8 weeks the remaining rats were (a) maintained on their previous treatment; (b) "crossed over" to their reciprocal treatment; or (c) administered vehicle only. At the end of this second 8-wk treatment period all rats were sacrificed. Bone mineral density of the distal femur, histomorphometric measurements of the proximal tibia and mechanical testing of the distal femur and selected vertebral bodies were performed. Our results demonstrated that (a) the gains in bone mass, trabecular connectivity and mechanical strength induced by PTH can be maintained by estrogen alone, but are reversed when both agents are withdrawn; and (b) rats with established osteopenia, maintained on estrogen treatment alone, can derive the full beneficial effects from the addition of PTH to the treatment at a later date. These data indicate that combined and/or sequential use of antiresorptive and anabolic agents may be a promising approach to the treatment of osteoporosis. (J. Clin. Invest. 1995. 96:2331-2338

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“…4) . However, improvement of BMD in the SEM m 30µg/kg PTH was enough to induce an anabolic effect [14] .…”

Section: Discussionmentioning

confidence: 98%

“…Intermittent administration of PTH has been shown to prevent the development of osteopenia in rats soon after ovariectomy and to restore lost bone mass in osteopenic, OVX rats [11][12][13][14] . We employed PTH at a dosage of 30µg/kg, 3 times per week for 8 weeks, because we had already confirmed in a previous study that T .…”

Section: Discussionmentioning

confidence: 99%

Effects of single and concurrent intermittent administration of human parathyroid hormone and bisphosphonate cimadronate on bone mineral densities of femur in ovariectomized rats

et al. 1995

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: This study compared the single administration of human parathyroid hormone [hPTH(1-34)] or bisphosphonate cimadronate (YM-175), and concurrent therapy with both of these agents for restoration of lost bone mineral density (BMD) in ovariectomized (OVX) rats . Animals were untreated for 4 weeks after surgery, and then injected s .c . with vehicle (OVX -V), hPTH(1-34) (30ug/kg) (OVX+P), YM-175 (5u.g/kg) (OVX+Y), ora combination of these two (OVX+P+Y), 3 days a week, for 8 weeks, and killed . BMD of distal, middle, and total femur were determined by dual-energy X-ray absorptiometry (DXA) . BMD of distal and total femur, but not of midfemur, decreased at both 4 weeks and 12 weeks after ovariectomy . In the distal femoral BMD, although OVX+Y failed to restore lost BM .D in OVX rats, either OVX+P or OVX+P+Y could reverse BMD lost due to OVX . Midfemoral BMD was unchanged through OVX or both single treatments, whereas this parameter was increased only in OVX+P+Y . These results suggest that concurrent treatment with PTH and YM-175 results in a bone anabolic effect not only in cancellous bone but also in cortical bone .

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Maintenance of bone mass by physical exercise after discontinuation of intermittent hPTH(1–34) administration

Cited by 34 publications

References 33 publications

Effect of Treadmill Exercise on Bone Mass in Female Rats

Effect of Treadmill Exercise on Bone Mass in Female Rats

Effects of reciprocal treatment with estrogen and estrogen plus parathyroid hormone on bone structure and strength in ovariectomized rats.

Effects of single and concurrent intermittent administration of human parathyroid hormone and bisphosphonate cimadronate on bone mineral densities of femur in ovariectomized rats

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