Maintenance of epithelial cell differentiation: The mode of action of vitamin A

Luca, Luigi De; Maestri, Nancy E.; Bonanni, F; Nelson, David P.

doi:10.1002/1097-0142(197211)30:5<1326::aid-cncr2820300527>3.0.co;2-j

Cited by 74 publications

(16 citation statements)

References 13 publications

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“…There are several mechanisms by which a carotenoid can function in cancer prevention. As a provitamin A, a carotenoid would have an effect on cellular differentiation and proliferation (DeLuca et al, 1972;Sporn and Roberts, 1983;DiGiovanni, 1990). Moreover, the antioxidant function could prevent free radical-induced damage to cellular DNA and other molecules (Burton, 1989).…”

Section: Observational Epidemiologymentioning

confidence: 99%

Carotenoid actions and their relation to health and disease

Krinsky

Johnson

2005

Molecular Aspects of Medicine

1,189

752

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Section: Observational Epidemiologymentioning

confidence: 99%

Carotenoid actions and their relation to health and disease

Krinsky

Johnson

2005

Molecular Aspects of Medicine

1,189

752

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“…There are several possible cancer prevention mechanisms that can explain the favorable effect of carotenoids toward cancer development (7,45). Carotenoids can function as a provitamin A having effect on cellular differentiation and proliferation (46,47). Moreover their anticarcinogenic effect lies in the ability to act as antioxidants, quenching free radicals, reducing damage from reactive oxidant species, and inhibiting lipid peroxidation (45).…”

Section: Discussionmentioning

confidence: 83%

Carotenoid Intake from Natural Sources and Head and Neck Cancer: A Systematic Review and Meta-analysis of Epidemiological Studies

Leoncini

Nedovic

Panić

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Because of their role as antioxidants, the intake of carotenoids has been hypothesized to reduce the risk of head and neck cancer (HNC). We conducted a systematic review and meta-analysis of the epidemiological studies to investigate whether the intake of specific carotenoids from dietary sources, as well as combined carotenoids, is associated with the risk of HNC according to cancer subsites. A comprehensive literature search of the Medline and Scopus databases was conducted. Sixteen articles were identified from the literature search, of which 15 were case-control studies and one prospective cohort study. The risk reduction associated with b-carotene equivalents intake was 46% (95% CI, 20%-63%) for cancer of oral cavity and 57% (95% CI, 23%-76%) for laryngeal cancer. Lycopene and b-cryptoxanthin also reduced the risk for laryngeal cancer; the ORs for the highest category compared with the lowest one of carotenoid intake were 50% (95% CI, 11%-72%) and 59% (95% CI, 49%-67%), respectively. Lycopene, a-carotene, and b-cryptoxanthin were associated with at least 26% reduction in the rate of oral and pharyngeal cancer (95% CI, 2%-44%). Our systematic review and meta-analysis on dietary carotenoids intake and HNC showed carotenoids to act protectively against HNC, in relation to most of single nutrients and subsites. Cancer Epidemiol Biomarkers Prev; 24(7); 1003-11. Ó2015 AACR.

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“…Several plausible mechanisms have been reported for such a favourable effect of carotenoids [46, 47]. Some of the carotenoids can function as a provitamin A, which would have an effect on cellular differentiation and proliferation [48, 49]. Moreover, carotenoids may act as antioxidants, quenching free radicals, reducing damage from reactive oxidant species, and inhibiting lipid peroxidation [46].…”

Section: Discussionmentioning

confidence: 99%

Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

et al. 2015

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Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case–control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29–47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24–50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6–29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0–32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p < 0.05). The odds ratio for the combined effect of low carotenoid intake and high alcohol or tobacco consumption versus high carotenoid intake and low alcohol or tobacco consumption ranged from 7 (95 % CI 5–9) to 33 (95 % CI 23–49). A diet rich in carotenoids may protect against HNC. Persons with both low carotenoid intake and high tobacco or alcohol are at substantially higher risk of HNC.

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Maintenance of epithelial cell differentiation: The mode of action of vitamin A

Cited by 74 publications

References 13 publications

Carotenoid actions and their relation to health and disease

Carotenoid actions and their relation to health and disease

Carotenoid Intake from Natural Sources and Head and Neck Cancer: A Systematic Review and Meta-analysis of Epidemiological Studies

Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

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