2014
DOI: 10.1038/nn.3731
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Maintenance of postmitotic neuronal cell identity

Abstract: The identity of specific cell types in the nervous system is defined by the expression of neuron type–specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how gene batteries that define the terminally differentiated state of a neuron type are maintained throughout the life of an animal. We provide here an overview of studies in invertebrate and vertebrat… Show more

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Cited by 170 publications
(192 citation statements)
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“…Therefore, it is plausible that in the developing cortex, once neuronal migration is completed, neurons transit to a post-mitotic stage due to the loss of centrosome integrity that might occur during dendrite outgrowth. Altogether, our results not only suggest that the post-mitotic neuronal cell identity is achieved gradually but also shed light on potential regulatory programs that function later on to maintain this terminally differentiated state [63].…”
Section: Discussionmentioning
confidence: 59%
“…Therefore, it is plausible that in the developing cortex, once neuronal migration is completed, neurons transit to a post-mitotic stage due to the loss of centrosome integrity that might occur during dendrite outgrowth. Altogether, our results not only suggest that the post-mitotic neuronal cell identity is achieved gradually but also shed light on potential regulatory programs that function later on to maintain this terminally differentiated state [63].…”
Section: Discussionmentioning
confidence: 59%
“…A TF acting on terminal specification binds to cis-acting regulatory motifs present in target genes that determine the neurotransmitter phenotype and may continue later in life maintaining the same postmitotic identity (11). A similar scenario has been found more recently in vertebrates, after the identification of the genetic programs that give birth and maintain serotonergic (12), dopaminergic (13), and noradrenergic neurons (14) in the mouse nervous system.…”
mentioning
confidence: 64%
“…TFs that specify neuronal-subtype identities during embryonic development may continue to drive cell-specific gene expression and maintain postmitotic neuronal identities later in life (11). This may be the case for ISL1 acting on POMC neurons because Isl1 and Pomc coexpress in the ventral hypothalamus across the mouse lifespan.…”
Section: Isl1 Regulates Hypothalamic Pomc Expression Across Differentmentioning
confidence: 99%
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“…Terminal selector transcription factors establish subtype identities of differentiating neurons and their expression is activated at the cell-cycle exit (Deneris and Hobert, 2014). Our earlier studies demonstrated that Gata2 and Tal2 act as post-mitotic selectors during development of midbrain and diencephalic GABAergic neurons (Kala et 2013).…”
Section: Tal1 Gata2 and Gata3 As Selector Transcription Factors Of Gmentioning
confidence: 99%