1978
DOI: 10.1136/bmj.2.6134.433
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Maintenance treatment of duodenal ulcer with cimetidine.

Abstract: and will be fewer in number than those at present receiving limited-period oxygen. We would take issue with the conclusions of Dr Jones and his colleagues. Current domiciliary oxygen supply is costly, inefficient, and uses outdated equipment. Changes will have to be made, but only on the basis of a clearer knowledge of the type of patient likely to benefit, the duration and quantity of daily therapy required for clinical benefit, and a thorough evaluation of new techniques of delivery, "G" size cylinders, oxyg… Show more

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Cited by 8 publications
(9 citation statements)
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“…Others have shown that basal daytime output of acid may also be significantly decreased by transdermal delivery of hyoscine methobromide.8 The transdermal therapeutic system delivers the drug at a steady rate over 72 h. 9 The relapse rate of healed duodenal ulcers may be significantly decreased by the nightly administration of cimetidine 400 mg, which inhibits overnight secretion of acid. 10 This system is therefore potentially useful as a maintenance treatment for healed duodenal ulcers, either alone or in combination with a smaller than usual dose of histamine H.-receptor blocking drugs. The ease of a schedule of three-day administration is especially attractive.…”
Section: Discussionmentioning
confidence: 99%
“…Others have shown that basal daytime output of acid may also be significantly decreased by transdermal delivery of hyoscine methobromide.8 The transdermal therapeutic system delivers the drug at a steady rate over 72 h. 9 The relapse rate of healed duodenal ulcers may be significantly decreased by the nightly administration of cimetidine 400 mg, which inhibits overnight secretion of acid. 10 This system is therefore potentially useful as a maintenance treatment for healed duodenal ulcers, either alone or in combination with a smaller than usual dose of histamine H.-receptor blocking drugs. The ease of a schedule of three-day administration is especially attractive.…”
Section: Discussionmentioning
confidence: 99%
“…Maintenance treatment with cimetidine in a low dose is effective in preventing duodenal ulcer relapse (Bodemar and Walan, 1978;Blackwood, Maudgal and Northfield, 1978;Gumand-H0yer et al, 1978;Burland et al, 1978;Gray et al, 1978;Hetzel et al, 1978). In the prevention of gastric ulcer relapse cimetidine seems equally effective (Machell et al, 1979;Birger Jensen et al, 1979).…”
Section: Introductionmentioning
confidence: 99%
“…Summary of maintenance trials ofcimetidine in duodenal ulcer: comparison with placebo(Burland et al, 1978) …”
mentioning
confidence: 99%