Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways

Luna‐Vital, Diego A.; Luzardo-Ocampo, Iván; Cuellar-Núñez, M. Liceth; Loarca‐Piña, Guadalupe; Mejía, Elvira González de

doi:10.1016/j.jnutbio.2020.108343

Cited by 62 publications

(30 citation statements)

References 53 publications

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“…Phenolic acids, such as gallic, ferulic and other hydroxycinnamic acid derivatives, are found in a variety of foods, including olive oil, whole grains, fruits, vegetables, nuts, tea, coffee and red wine [10,95,101,102]. Some phenolic acids have been reported to stimulate the secretion of adiponectin and the phosphorylation of AMPK associated with inhibition of NF-κB activation and macrophage infiltration, resulting in reduced adipogenesis and adipose inflammation in vitro and in obese animals [103][104][105]. Flavonoids, with about 6000 molecules, are the largest group of polyphenols [106].…”

Section: Polyphenols As the Most Abundant Antioxidant In Meddietmentioning

confidence: 99%

“…Therefore, AMPK has been considered as an attractive therapeutic target for obesity management [20]. Ferulic acid, largely found in whole grains, has been shown to exert anti-obesity activity through the upregulation of AMPK phosphorylation, which is accompanied by a decrease in whole-body oxidative stress and inflammation-evidenced by decreased ROS generation, pro-inflammatory cytokines production, adhesion molecules expression, and circulating LDL levels-and increased adiponectin expression and circulating high-density lipoprotein (HDL) levels in HFD-fed obese mice [105]. Likewise, AMPK signaling partially mediates resveratrol-dependent anti-oxidant effects through reversing mitochondrial dysfunction, increasing total antioxidative capability, elevating activity of SOD and GPx and curtailing malondialdehyde (MDA) and carbonyl protein contents in HFD-fed obese mice [145].…”

Section: Meddiet Polyphenols Counteract Oxidative Stress and Inflammamentioning

confidence: 99%

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Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

et al. 2021

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Nutrition transition can be defined as shifts in food habits, and it is characterized by high-fat (chiefly saturated animal fat), hypercaloric and salty food consumption at the expense of dietary fibers, minerals and vitamins. Western dietary patterns serve as a model for studying the impact of nutrition transition on civilization diseases, such as obesity, which is commonly associated with oxidative stress and inflammation. In fact, reactive oxygen species (ROS) overproduction can be associated with nuclear factor-κB (NF-κB)-mediated inflammation in obesity. NF-κB regulates gene expression of several oxidant-responsive adipokines including tumor necrosis factor-α (TNF-α). Moreover, AMP-activated protein kinase (AMPK), which plays a pivotal role in energy homeostasis and in modulation of metabolic inflammation, can be downregulated by IκB kinase (IKK)-dependent TNF-α activation. On the other hand, adherence to a Mediterranean-style diet is highly encouraged because of its healthy dietary pattern, which includes antioxidant nutraceuticals such as polyphenols. Indeed, hydroxycinnamic derivatives, quercetin, resveratrol, oleuropein and hydroxytyrosol, which are well known for their antioxidant and anti-inflammatory activities, exert anti-obesity proprieties. In this review, we highlight the impact of the most common polyphenols from Mediterranean foods on molecular mechanisms that mediate obesity-related oxidative stress and inflammation. Hence, we discuss the effects of these polyphenols on a number of signaling pathways. We note that Mediterranean diet (MedDiet) dietary polyphenols can de-regulate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and NF-κB-mediated oxidative stress, and metabolic inflammation. MedDiet polyphenols are also effective in upregulating downstream effectors of several proteins, chiefly AMPK.

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Section: Polyphenols As the Most Abundant Antioxidant In Meddietmentioning

confidence: 99%

Section: Meddiet Polyphenols Counteract Oxidative Stress and Inflammamentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

et al. 2021

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“…AMPK and Sirt1 are important sensors of the energy status that together with PGC-1α regulate energy homeostasis and stimulate FNDC5/irisin expression, thus inducing beige adipogenesis [ 118 ]. The regulation of adipogenesis through the AMPK/SIRT1 pathway has also been described in HFD fed mice treated with maize extract rich in ferulic acid and anthocyanins [ 119 ].…”

Section: Anthocyaninsmentioning

confidence: 99%

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

et al. 2020

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The prevention and treatment of obesity is primary based on the follow-up of a healthy lifestyle, which includes a healthy diet with an important presence of bioactive compounds such as polyphenols. For many years, the health benefits of polyphenols have been attributed to their anti-oxidant capacity as free radical scavengers. More recently it has been described that polyphenols activate other cell-signaling pathways that are not related to ROS production but rather involved in metabolic regulation. In this review, we have summarized the current knowledge in this field by focusing on the metabolic effects of flavonoids. Flavonoids are widely distributed in the plant kingdom where they are used for growing and defensing. They are structurally characterized by two benzene rings and a heterocyclic pyrone ring and based on the oxidation and saturation status of the heterocyclic ring flavonoids are grouped in seven different subclasses. The present work is focused on describing the molecular mechanisms underlying the metabolic impact of flavonoids in obesity and obesity-related diseases. We described the effects of each group of flavonoids in liver, white and brown adipose tissue and central nervous system and the metabolic and signaling pathways involved on them.

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“…This results from an altered balance of key transcription factors able to promote inflammation through the induction of molecules such as TNFα , IL-6 , IL-1β , and Toll-like receptor ( TLR ) 4. These, in turn, exacerbate the inflammatory state [ 52 , 53 , 54 ] and can promote a favourable microenvironment to CRC onset/evolution [ 55 ].…”

Section: Fatty Acids and Adipose Tissue Homeostasismentioning

confidence: 99%

Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response

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et al. 2021

Cells

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Colorectal cancer (CRC) is among the major threatening diseases worldwide, being the third most common cancer, and a leading cause of death, with a global incidence expected to increase in the coming years. Enhanced adiposity, particularly visceral fat, is a major risk factor for the development of several tumours, including CRC, and represents an important indicator of incidence, survival, prognosis, recurrence rates, and response to therapy. The obesity-associated low-grade chronic inflammation is thought to be a key determinant in CRC development, with the adipocytes and the adipose tissue (AT) playing a significant role in the integration of diet-related endocrine, metabolic, and inflammatory signals. Furthermore, AT infiltrating immune cells contribute to local and systemic inflammation by affecting immune and cancer cell functions through the release of soluble mediators. Among the factors introduced with diet and enriched in AT, fatty acids (FA) represent major players in inflammation and are able to deeply regulate AT homeostasis and immune cell function through gene expression regulation and by modulating the activity of several transcription factors (TF). This review summarizes human studies on the effects of dietary FA on AT homeostasis and immune cell functions, highlighting the molecular pathways and TF involved. The relevance of FA balance in linking diet, AT inflammation, and CRC is also discussed. Original and review articles were searched in PubMed without temporal limitation up to March 2021, by using fatty acid as a keyword in combination with diet, obesity, colorectal cancer, inflammation, adipose tissue, immune cells, and transcription factors.

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Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways

Cited by 62 publications

References 53 publications

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

Antioxidant and Anti-Inflammatory Potential of Polyphenols Contained in Mediterranean Diet in Obesity: Molecular Mechanisms

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response

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