Major Adverse Events Associated With Treatment of Infantile Spasms

Partikian, Arthur; Mitchell, Wendy G.

doi:10.1177/0883073807310988

Cited by 29 publications

(22 citation statements)

References 30 publications

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“…ACTH is given using intramuscular injection. Effective short-duration treatment may avoid major side effects associated with IS treatment [41]. The most frequent adverse effects associated with short-duration ACTH treatment are irritability, increased appetite leading to weight gain [39], and Cushingoid features.…”

Section: Resultsmentioning

confidence: 99%

Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents

Wheless

Gibson

Rosbeck³

et al. 2012

BMC Pediatr

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BackgroundInfantile spasms (IS; West syndrome) is a severe form of encephalopathy that typically affects infants younger than 2 years old. Pediatricians, pediatric neurologists, and other pediatric health care providers are all potentially key early contacts for families who have an infant with IS. The objective of this article is to assist pediatric health care providers in the detection of the disease and in the counseling and guidance of families who have an infant with IS.MethodsTreatment guidelines, consensus reports, and original research studies are reviewed to provide an update regarding the diagnosis and treatment of infants with IS. Web sites were searched for educational and supportive resource content relevant to providers and families of patients with IS.ResultsEarly detection of IS and pediatrician referral to a pediatric neurologist for further evaluation and initiation of treatment may improve prognosis. Family education and the establishment of a multidisciplinary continuum of care are important components of care for the majority of patients with IS. The focus of the continuum of care varies across diagnosis, initiation of treatment, and short- and long-term needs. Several on-line educational and supportive resources for families and caregivers of patients with IS were identified.ConclusionsGiven the possibility of poor developmental outcomes in IS, including the emergence of other seizure disorders and cognitive and developmental problems, early recognition, referral, and treatment of IS are important for optimal patient outcomes. Dissemination of and access to educational and supportive resources for families and caregivers across the lifespan of the child with IS is an urgent need. Pediatric health care providers are well positioned to address these needs.

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Section: Resultsmentioning

confidence: 99%

Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents

Wheless

Gibson

Rosbeck³

et al. 2012

BMC Pediatr

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“…Developmental outcomes are unclear, and it is not known if treatment produces a partial response in spasms and hypsarrhythmia. Effective short‐duration treatment may avoid major side effects associated with first‐ and second‐line treatments for IS (Partikian & Mitchell, 2007). Timely management of patients who are refractory to first‐line therapy is critical (Hrachovy & Frost, 2003; Lux & Osborne, 2004).…”

Section: Therapeutic Options For Ismentioning

confidence: 99%

Infantile spasms: A U.S. consensus report

et al. 2010

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SUMMARYThe diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician. Although an evidence-based practice guideline with full literature review was published in 2004, diversity in IS evaluation and treatment remains and highlights the need for further consensus to optimize outcomes in IS. For this purpose, a working group committed to the diagnosis, treatment, and establishment of a continuum of care for patients with IS and their families-the Infantile Spasms Working Group (ISWG)-was convened. The ISWG participated in a workshop for which the key objectives were to review the state of our understanding of IS, assess the scientific evidence regarding efficacy of currently available therapeutic options, and arrive at a consensus on protocols for diagnostic workup and management of IS that can serve as a guide to help specialists and general pediatricians optimally manage infants with IS. The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first-line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification. Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS.

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“…These include weight and blood pressure changes, infections, also with opportunistic organism, hyperglycemia and electrolyte abnormalities, cushingoid appearance, development of new seizure types, sleep and behaviour abnormalities and decrease of bone density sometimes with fractures, skin rashes with intravascular coagulation and even death. In the referred studies doses of ACTH were however mostly superior to 150 U/square m/day [97,98]. For this reason a much lower dosage and shorter treatment have recently been utilized.…”

Section: Treatmentmentioning

confidence: 99%

Infantile spasms: review of the literature and personal experience

Fois

2010

Ital J Pediatr

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This epileptic disorder has become a classic topic for neuropediatricians and the interest is documented by the large number of publications on this subject.The relative frequency among the epileptic syndromes is an another reason why not only neuropediatricians but also general pediatricians must be fully informed about diagnostic, clinical, imaging and genetic aspects.Early diagnosis is of paramount importance in order to obtain even complete results in patients with so called idiopathic situations. A number of problems are still to be solved. There is no agreement on the type and the schedule of treatment. A common denominator about this problem is not jet available even if some advances in this regard have been accomplished. Of paramount importance is an accurate clinical and laboratory examination as a prerequisite regarding prognosis and results of therapy in every single case.However, even if more than 170 years have elapsed since the first communication of dr. West on the peculiar syndrome that his child was suffering of, the interest of scientists on this subject has now been enriched and rewarded.

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Major Adverse Events Associated With Treatment of Infantile Spasms

Cited by 29 publications

References 30 publications

Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents

Infantile spasms (West syndrome): update and resources for pediatricians and providers to share with parents

Infantile spasms: A U.S. consensus report

Infantile spasms: review of the literature and personal experience

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