Major and Minor Discordance in the Diagnosis of Osteoporosis among Irish Men and Women Using Hip and Spine Dual-Energy X-Ray Absorptiometry

McGowam, Bernie; McPartland, Aoife; Silke, Charlotte; Whelan, Bryan

doi:10.1016/j.jocd.2016.08.048

Cited by 1 publication

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“…The prevalence of discordance in this study is comparable to the findings of previous studies. 6 , 23 Walking speed was a significant negative predictor in this study. Sex and BMI were also significantly correlated with T -score discordance after excluding BIA data from the model ( Table 2 ).…”

Section: Discussionsupporting

confidence: 51%

T-score discordance between hip and lumbar spine: risk factors and clinical implications

Chiang

Jang

Chen

et al. 2023

Therapeutic Advances in Musculoskeletal

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Background: T-score discordance is common in osteoporosis diagnosis and leads to problems for clinicians formulating treatment plans. Objectives: This study investigated the potential predictors of T-score discordance and compared fracture risk among individuals with varying T-score discordance status. Design: This was a single-center cross-sectional study conducted at Wan Fang Hospital, Taipei City, between 1 February 2020 and 31 January 2022. Methods: The present study enrolled patients aged ⩾50 years who received advanced bone health examination. Participants with a history of fracture surgery or underlying musculoskeletal diseases were excluded. Bioelectrical impedance analysis and dual-energy X-ray absorptiometry were used to determine the body composition and T-score, respectively. Discordance was defined as different T-score categories between the lumbar spine and hip. The impact of discordance on an individual’s fracture risk was assessed using the Fracture Risk Assessment Tool (FRAX). Results: This study enrolled 1402 participants (181 men and 1221 women). Of the 912 participants diagnosed with osteoporosis, 47 (5%) and 364 (40%) were categorized as having major and minor discordance, respectively. Multinomial logistic regression revealed that decreased walking speed was significantly correlated with major discordance but not osteoporosis in both the hip and lumbar spine (odds ratio of 0.25, p = 0.04). The adjusted FRAX scores for the major osteoporotic fracture risks of the major and minor discordance groups were approximately 14%, which was significantly lower than that of people having osteoporosis in both the hip and lumbar spine. Conclusions: Walking speed exhibited the most significant correlation with major discordance in patients with osteoporosis. Although adjusted major fracture risks were similar between the major and minor discordance groups, further longitudinal studies are warranted to confirm this finding. Registrations: This study was approved by the Ethics Committee of Taipei Medical University on 01/04/2022 (TMU-JIRB N202203088).

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Section: Discussionsupporting

confidence: 51%