Major and Minor ECG Abnormalities in Asymptomatic Women and Risk of Cardiovascular Events and Mortality

Abstract

ESTING 12-LEAD ELECTROCARdiogram (ECG) abnormalities are independently associated with incident coronary heart disease (CHD) and cardiovascular disease (CVD) events. 1-14 Many of the prior studies included only men or compared men and women, but the women were not selected for age or the presence or absence of underlying heart disease. 1-13 Data are sparse regarding the prognostic significance of baseline ECG abnormalities in postmenopausal women without clinically manifest heart disease. 14 Furthermore, there is no information on the prognostic significance of incident ECG abnormalities. The Women's Health Initiative (WHI) clinical trials of hormone therapy examined whether in healthy postmenopausal women a combination of estrogen and progestin would reduce CHD and CVD events. 15 The study showed that there was a significant increase in CHD rates among women taking hormone therapy compared with the placebo group. 16 A subsequently published article on the risk of CHD found that clinical characteristics or biomarkers did not significantly modify the treatment-related risk of CHD end points. 17

Measurement of ECG abnormalities and cardiovascular risk classification: a cohort study of primary care patients in the Netherlands

“…3 Two studies have reported on the change in the AUC. 19,20 These studies showed slight improvements in AUC, of a similar magnitude as in the current study. Yet the change in the AUC is of limited clinical usefulness.…”

“…The discriminative value of both models was expressed with the area under the receiver operator curve (AUC). The 10-year absolute risk to develop e3 British Journal of General Practice, January 2015 [18][19][20] was calculated. The NRI quantifies the percentage of correct movement across categories for those with and without events.…”

Electrocardiogram Abnormalities and Cardiovascular Mortality in Elderly Patients with CKD

“…In addition, different studies may vary with regard to the specific ECG classification into major and minor abnormalities (25)(26)(27)(28)(29). The nomenclature of major and minor ECG abnormalities used in this study, although consistent with other publications from the CHS (30,31), does not reflect the current classification according to the Minnesota criteria (32).…”

Alcohol Drinking and Cardiovascular Risk in a Population With High Mean Alcohol Consumption

“…Most biologic assays were performed by the Central Laboratory of Lausanne University Hospital, which is regularly checked for performance and quality. As in other studies, 10 we calculated 10-year CAD risk for each participant using the Framingham risk score. 11 This version of the Framingham risk score includes diabetes mellitus and estimates the risk for CAD (angina pectoris, recognized and unrecognized myocardial infarction, coronary insufficiency, and CAD death).…”