Major burns: Part 1. Epidemiology, pathophysiology and initial management

McCann, C.; Watson, Amanda; Barnes, David

doi:10.1016/j.bjae.2021.10.001

Cited by 18 publications

(6 citation statements)

References 21 publications

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“…Baina, baliteke, prozesu hori gehiegizkoa izatea eta, beraz, bai lesio gunean eta baita inguruko organoetan ere aldaketak antzeman daitezke eta ondorioz akats multiorganikoa eta heriotza eragin ditzake. Horri erreduren ondoriozko shock-a deritzo [17,18,19]. Bitartekari hauek kalte larriak eragingo dituzte; kasurik larrienean heriotza ere eragin dezakete.…”

Section: Erredurakunclassified

Azaleko erredurak: Gaur egungo egoera, terapia eskuragarriak eta etorkizuneko terapiak

Ugarte Teran,

Igartua Olaechea,

Hernández Martín

et al. 2024

EKAIA

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Azala gizakion organorik handiena da, eta bertako lesioak, hala nola, erredurak, gizartean geroz eta garrantzia handiagoa hartzen ari dira. Erredurak hainbat kausaren ondorio izan daitezke, eta oro har, lesio hauetan azaleko geruzak—epidermisa, dermisa eta/edo hipodermisa— kaltetuko dira; zenbait kasutan baita bestelako organo batzuk ere. Lesioak arinak badira, tratamendu berezi gabe sendatuko dira. Baina, larriak diren kasuan —lan honetan aztertuko direnak— tratamendua eraginkorra izan dadin terapia berezietara jo beharra dago. Gaur egun, erredura larriak tratatu eta azalaren egitura berreskuratzeko, merkatuan hainbat terapia daude: injertoak, eta ordezko dermikoak, bai oinarri zelularrekoak zein oinarri zelularrik gabekoak. Guztiekin erreduren tratamendurako erabilgarritasuna frogatu den arren, oraindik guztiek hobekuntzarako tartea dutela ere ondorioztatu da. Hori horrela, terapia horietan oinarritutako berrikuntzak eta terapia edo teknologia berriak aztertzen ari dira, adibidez, ingeniaritza genetikoa, 3D bio-inprimaketa, nano-partikuletan oinarritutako teknologiak eta zelula ama-mesenkimaletan (MSC) oinarritutako terapiak. Hori dela-eta, lan honetan merkatuan dauden terapia desberdinen ekintza mekanismoak, bakoitza zein kasutan erabili daitekeen eta dituzten abantailak eta desabantailak azalduko dira. Desabantaila horiek —prezioa, eraginkortasuna eta produkzioa batez ere— hobetzeko jarraitutako pausoak eta ikerkuntzan dauden terapiak ere aztertu dira. Terapia berri hauen ikerketak urriak dira, eta erronkak ugariak dira. Hala ere, uste da ikerkuntza berriak erredura larriak tratatzeko eraginkorrak izango direla.

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Section: Erredurakunclassified

Azaleko erredurak: Gaur egungo egoera, terapia eskuragarriak eta etorkizuneko terapiak

Ugarte Teran,

Igartua Olaechea,

Hernández Martín

et al. 2024

EKAIA

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“…Severe thermal burns are devastating injuries, requiring immediate specialised care. They are defined as burns with >15% total body surface area (TBSA) [ 1 ]. Following insult, there is a profound and prolonged pathophysiological process where systemic inflammatory and compensatory anti-inflammatory processes are induced [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Use of Oxandrolone in the Management of Severe Burns: A Multi-service Survey of Burns Centres and Units Across the United Kingdom

Feathers,

Richardson,

Cornier

et al. 2024

Cureus

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Introduction Severe thermal burns are a catastrophic injury. Those surviving the initial insult are subject to life-long disability, prolonged hospital admission, nutritional issues and poor wound healing. Oxandrolone has been shown to reduce hospital duration and promote lean body mass. Despite not being licenced for use in burns trauma within the United Kingdom (UK), services across the country utilise Oxandrolone in the management of severe burns. We aim to analyse the use of Oxandrolone in major burns across burns services within the UK. Methods We conducted a survey across all burn centres and units across the UK. Any burns service provider with experience in patient management of patients sustaining burns with a total body surface area >15% was included. All services were identified using the British Burns Association website. We conducted a survey of all centres and units and contacted them via telephone through the trust’s switchboard. Responses were accepted from any healthcare staff familiar with the day-to-day in-patient care of patients on the ward. Services with no in-patient services were excluded. Results A total of 24 burns centres and services responded to our survey. Twelve of the respondents were in a burns unit and 12 were in a burns centre. Eight respondents were paediatric facilities, and the remaining 16 dealt with adult burns. In total, 16/24 (66.6%) services reported using Oxandrolone. Conversely, 8/24 (33.3%) burns services denied using Oxandrolone. 7/12 (58.3%) burns units use Oxandrolone in the management of burns. 5/12 (42.7%) burns units do not use Oxandrolone in severe burns. 9/12 (75%) of burns centres described using Oxandrolone, whilst the remaining 3/12 (25%) did not. Discussion Oxandrolone is used varyingly across burns services across the UK. Burns centres were more likely to use Oxandrolone compared to units. We also find that more paediatric services used Oxandrolone in comparison to adult services. Studies have shown that the benefit of Oxandrolone is not age-dependent. Further work is required to assess the impact of this medication on patients with severe burns and national guidance would help further improve burns management across the UK.

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“…Burn wounds are among the most frequently occurring traumas, accounting for more than 256,000 deaths worldwide 1 . Depending on the depth and severity of penetration through the skin's surface, burns are sub-classified as first, second or third degree.…”

Section: Introductionmentioning

confidence: 99%

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

Shadman-Manesh

Gholipour-Kanani

Najmoddin

et al. 2023

Sci Rep

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Considering the great potential of egg yolk oil (EYO) in management of burn wounds and superb biological properties of polycaprolactone (PCL) and polyethylene glycol (PEG), hereby, a PCL-PEG-EYO scaffold was developed by electrospinning method for burn healing. The physico-chemical characterizations were performed using SEM, FTIR and contact angle tests. The biological properties of the fabricated scaffolds were evaluated by antibacterial test, in vitro cell culturing, MTT assay and in vivo experiments. The SEM images of PCL-PEG-EYO nanofibers demonstrated a uniform bead-free morphology with 191 ± 61 nm diameter. The fabricated scaffold revealed hydrophilicity with the water contact angel of 77°. No cytotoxicity was observed up to 7 days after cell culturing onto the PCL-PEG-EYO nanofibrous surface. The presence of EYO in the PCL-PEG-EYO scaffold meaningfully improved the cell viability, proliferation and attachment compared to PCL-PEG scaffold. Moreover, the PCL-PEG-EYO scaffolds demonstrated antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria strain. Finally, a statistically significant enhancement in wound closure, re-epithelialization, angiogenesis and collagen synthesis was observed at the end of 21-day treatment period using PCL-PEG-EYO nanofibrous scaffold. Overall, the PCL-PEG-EYO nanofibrous scaffolds demonstrated a great potential in management of full thickness burn wounds in vivo.

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Major burns: Part 1. Epidemiology, pathophysiology and initial management

Cited by 18 publications

References 21 publications

Azaleko erredurak: Gaur egungo egoera, terapia eskuragarriak eta etorkizuneko terapiak

Azaleko erredurak: Gaur egungo egoera, terapia eskuragarriak eta etorkizuneko terapiak

The Use of Oxandrolone in the Management of Severe Burns: A Multi-service Survey of Burns Centres and Units Across the United Kingdom

Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing

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