Major cardiovascular events and readmission risk of patients post percutaneous coronary intervention in one year based on ApoB/ApoA-Ι

Abstract

Background: Percutaneous coronary intervention (PCI) is a practical and effective method for the treatment of coronary heart disease (CHD).The aim of this study is to assess the clinical value of ApoB/ApoA-Ι in predicting the major cardiovascular events(MACEs) and hospital readmission risk within one year in CHD patients post PCI. Methods: 1938 patients who underwent PCI treatment from January 2010 to December 2018 were included in this retrospective study. Basic information, medications and biochemical indicators were recorded at admission and the one year follow-up. Univariate and multivariate Cox proportional hazards regression model were performed to determine the relationship between ApoB/ApoA-Ι and MACEs, as well as readmission. The Kaplan-Meier curves were plotted to illustrate the cumulative incidence of MACEs and readmission. Predictive nomograms were established to predict prognosis for MACEs and readmission. Results: Cox regression analysis showed that ApoB/ApoA-Ι is an independent risk factor for MACEs in patients after PCI(P=0.031). The incidence of MACEs in the high-level ApoB/ApoA-Ι group (ApoB/ApoA-Ι ratio>0.824) increased within one year and the difference was statistically significant(P=0.037). The incidence of readmission increased within one year was not statistically significant. In addition, the nomogram predicted one year MACEs more accurately(C-index: 0.647).Conclusions: The ratio of ApoB/ApoA-Ι has important predictive value for the risk of MACEs occurrence in one year for CHD patients post PCI.