Major challenges in dermatophytosis treatment

Abstract

There is no part of the world can be cleared of the infection with dermatophytosis. Millions of persons and animals around the world are infected with specialized filamentous fungi called superficial infections of which dermatophyte are the most common agents. Dermatophyte infection incorporates a broad range of diseases involving particularly the nails, hair, and the skin. These infections were considered the most common causative agents of a patient visiting the dermatology. Dermatophytosis is mainly due to different species of dermatophytes that infect the cutaneous layer of the skin. There are many problems in the treatment of dermatophytosis that deserve to highlight because few studies have discussed this issue, especially dermatophyte management challenges became the state of anxiety in physicians and causing alarming distress to the patients recently. So the current review may serve as an impetus for researchers working in the field of medical mycology and antifungal drug design, as well as rationally reports and critically analyses the available knowledge by focusing and mentioning future steps strategies trying to find appropriate solutions regarding challenges in dermatophytosis management.

Chronic dermatophytosis: A clinical, epidemiological, mycological study

“…Superficial fungal infections are common issues that affect around 20-25% of people worldwide, with 30-70% of the adult population being asymptomatic carriers of dermatophytes [13,14]. Previously, infection with dermatophytes was thought to be an easy to treat disease in dermatological clinics yet, in the last several years, this notion has changed due to the appearance of numerous cases of infections in different parts of the world that are difficult to treat.…”

Factors affecting flowering of Pseudomonas aeruginosa in urine

“…Because of rising antimicrobial resistance in the healthcare system, one of the most significant difficulties for clinicians is providing sufficient therapy for infections caused by Gram-negative bacteria [1]. Pseudomonas aeruginosa (P. aeruginosa) is the most common Gram-negative rod infection, [2] especially in severely sick and vulnerable individuals [3]. Treatment options for P. aeruginosa infections have been severely limited due to antimicrobial resistance [4][5][6].…”

Isoflavaspidic Acid PB Extracted from Dryopteris fragrans (L.) Schott Inhibits Trichophyton rubrum Growth via Membrane Permeability Alternation and Ergosterol Biosynthesis Disruption

“…Superficial mycoses have affected about 20-25% of the worldwide population with incidence, in particular those involving dermatophyte infection, having increased in the recent decades [1,2]. Dermatophytosis are infections of the stratum corneum or keratinized adnexal structures caused by dermatophytes [3].…”