Major change in morphology of the talofibular ligaments during fetal development and growth

Kim, Ji Hyun; Jin, Zhe Wu; Hayashi, Shogo; Murakami, Gen; Rodríguez‐Vázquez, José Francisco; Abé, Hiroshi

doi:10.1007/s00276-022-02987-8

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Various techniques, including ultrasonography and histological examinations, had been investigated to study the differences in the fibular attachment structure of the anterior talofibular ligament (ATFL). The study conducted by Kim et al [ 20 ]. focuses on the morphological changes in the talofibular ligaments during fetal development and growth.…”

Section: Discussionmentioning

confidence: 99%

The increased anterior talofibular ligament–posterior talofibular ligament angle on MRI may help evaluate chronic ankle instability

et al. 2023

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Purpose This study intended to compare the difference between the anterior talofibular ligament (ATFL) and posterior talofibular ligament (PTFL) angle with chronic ankle instability (CAI) patients and healthy volunteers, and to confirm whether using the ATFL–PTFL angle could be a reliable assessment method for CAI, so as to improve the accuracy and specificity of clinical diagnosis. Methods This retrospective study included 240 participants: 120 CAI patients and 120 healthy volunteers between 2015 and 2021. The ATFL–PTFL angle of the ankle region was gaged in the cross-sectional supine position on MRI between two groups. After participants undergoing a comprehensive MRI scanning, ATFL–PTFL angles were regarded as the main indicator of patients with the injured ATFLs and healthy volunteers to compare, and were measured by an experienced musculoskeletal radiologist. Moreover, other qualitative and quantitative indicators referring to anatomical and morphological characteristics of the AFTL were included in this study with MRI, such as the length, width, thickness, shape, continuity, and signal intensity of the ATFL, which can be used as secondary indicators. Results In the CAI group, the ATFL–PTFL angle was 90.8° ± 5.7°, which was significantly different from the non-CAI group where the ATFL–PTFL angle for 80.0° ± 3.7° (p < 0.001). As for the ATFL-MRI characteristics, the length (p = 0.003), width (p < 0.001), and thickness (p < 0.001) in the CAI group were also significantly different from the non-CAI group. Over 90% of the cases, patients of the CAI group had injured ATFL with an irregular shape, non-continuous, and high or mixed signal intensity. Conclusion Compared with healthy people, the ATFL–PTFL angle of most CAI patients is larger, which can be used as a secondary index to diagnose CAI. However, the MRI characteristic changes of ATFL may not relate to the increased ATFL–PTFL angle.

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Section: Discussionmentioning

confidence: 99%

The increased anterior talofibular ligament–posterior talofibular ligament angle on MRI may help evaluate chronic ankle instability

et al. 2023

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“…The plantar calcaneonavicular ligament strengthened due to the tibialis posterior tendon in the fetuses (Uchiyama et al, 2014). The anterior and posterior talofibular ligaments also developed during early gestation (Kim et al, 2022). It is likely that these tendons and ligaments pushed the tarsal bones onto the early elongated malleolus of tibia.…”

Section: F I G U R E 6 Tangential Sections Of An Embryonic Foot (20 M...mentioning

confidence: 99%

Ontogenic transformation of the ankle from the initial mediolateral arrangement of the calcaneus and talus: A histological study of human embryos and early fetuses

Kim,

Ishizuka,

Kitamura

et al. 2024

Journal of Anatomy

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The human calcaneus is robust and provides a prominent heel for effective bipedal locomotion, although the adjacent talus has no muscle attachments. However, there is incomplete information about the morphological changes in these prominent bones during embryo development. We examined serial histological sections of 23 human embryos and early‐term fetuses (approximately 5–10 weeks' gestational age [GA]). At a GA of 5 weeks, the precartilage talus was parallel to and on the medial side of the calcaneus, which had a prolate spheroid shape and consisted of three masses. At a GA of 6 weeks, the cartilaginous talus extended along the proximodistal axis, and the tuber calcanei became long and bulky, with a small sustentaculum talus at the “distal” side. At a GA of 6 to 8 weeks, the sustentaculum had a medial extension below the talus so that the talus “rode over” the calcaneus. In contrast, the talus had a more complex shape, depending on the growth of adjacent bones. At a GA of 9 to 10 weeks, the talus was above the calcaneus, but the medial part still faced the plantar subcutaneous tissue because of the relatively small sustentaculum. Therefore, the final morphology appeared after an additional several weeks. Muscle activity seemed to facilitate growth of the tuber calcanei, but growth of the other parts of calcaneus, including the sustentaculum, seemed to depend on active proliferation at the different sites of cartilage. Multiple tendons and ligaments seemed to fix the talus so that it remained close to the calcaneus.

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Major change in morphology of the talofibular ligaments during fetal development and growth

Cited by 2 publications

References 19 publications

The increased anterior talofibular ligament–posterior talofibular ligament angle on MRI may help evaluate chronic ankle instability

The increased anterior talofibular ligament–posterior talofibular ligament angle on MRI may help evaluate chronic ankle instability

Ontogenic transformation of the ankle from the initial mediolateral arrangement of the calcaneus and talus: A histological study of human embryos and early fetuses

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