Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

Singh, Keerti; Krishnamurthy, Kandamaran; Greaves, Camille; Kandamaran, L.; Nielsen, Anders; Kumar, Alok

doi:10.1155/2014/651783

Cited by 34 publications

(30 citation statements)

References 20 publications

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“…In previous study in Egypt Down syndrome was the commonest chromosomal abnormalities [15,16]. The same finding was reported in Barbados [28].…”

Section: Discussionsupporting

confidence: 78%

“…However, a considerable variation in the frequency of various genetic/malformations disorders had been previously reported in different Arab and NonArab countries [2,[19][20][21][22]. Some studies, however, recorded higher proportions of central nervous system and cardiovascular system malformations followed by gastrointestinal tract and musculoskeletal systems [23][24][25][26][27][28]. But in contrast an Iranian study [29] reported genitourinary system as the one most often affected.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Morbidity profile of children referred to Genetic Unit of Mansoura University Childrens Hospital, Egypt.

El‐Gilany¹,

Yahia²,

Shokeir³

et al. 2017

Am J Prev Med Public Health

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“…In previous study in Egypt Down syndrome was the commonest chromosomal abnormalities [15,16]. The same finding was reported in Barbados [28].…”

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Morbidity profile of children referred to Genetic Unit of Mansoura University Childrens Hospital, Egypt.

El‐Gilany¹,

Yahia²,

Shokeir³

et al. 2017

Am J Prev Med Public Health

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“…[22] Congenital disorder is becoming an increasing burden on the health-care resources in the developing countries. [25] Studies from developed countries such as the UK and the USA have reported an overall decreasing trend of congenital disorder and have attributed the decline to increasing prenatal diagnosis and termination of pregnancy. [2627] Thus, importance of antenatal examination and consultation should be attached more for the parents to make proper planning and decision.…”

Section: Discussionmentioning

confidence: 99%

Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China

Wang

et al. 2016

Chinese Medical Journal

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Background:Globally, the proportion of child deaths that occur in the neonatal period remains a high level of 37–41%. Differences of cause in neonate death exist in different regions as well as in different economic development countries. The specific aim of this study was to investigate the causes, characteristics, and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit (NICU) of China.Methods:All the dead neonates admitted to 26 NICUs were included between January l, 2011, and December 31, 2011. All the data were collected retrospectively from clinical records by a designed questionnaire. Data collected from each NICU were delivered to the leading institution where the results were analyzed.Results:A total of 744 newborns died during the 1-year survey, accounting for 1.2% of all the neonates admitted to 26 NICUs and 37.6% of all the deaths in children under 5 years of age in these hospitals. Preterm neonate death accounted for 59.3% of all the death. The leading causes of death in preterm and term infants were pulmonary disease and infection, respectively. In early neonate period, pulmonary diseases (56.5%) occupied the largest proportion of preterm deaths while infection (27%) and neurologic diseases (22%) were the two main causes of term deaths. In late neonate period, infection was the leading cause of both preterm and term neonate deaths. About two-thirds of neonate death occurred after medical care withdrawal. Of the cases who might survive if receiving continuing treatment, parents’ concern about the long-term outcomes was the main reason of medical care withdrawal.Conclusions:Neonate death still accounts for a high proportion of all the deaths in children under 5 years of age. Our study showed the majority of neonate death occurred in preterm infants. Cause of death varied with the age of death and gestational age. Accurate and prompt evaluation of the long-term outcomes should be carried out to guide the critical decision.

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“…Our study reported that congenital heart disease and Down syndrome were the most common types of congenital anomalies compared to other types [13][14][15].…”

Section: Discussionmentioning

confidence: 61%

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

2018

KJAR

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Congenital anomalies comprise a wide range of abnormalities in body structure or function that are present at birth and are of prenatal origin. These are defined as structural changes that have significant medical, social or cosmetic consequences for the affected individual, and typically require medical intervention. According to our Knowledge, research is scarce on these conditions in Sulaimaniyah city. Therefore, the current study was conducted to investigate potential risk factors for congenital anomalies. A case-control study was carried out from March to August 2017 involving 400 children (200 cases and 200 controls) aged 0-5 years. Required data were obtained on the risk factors through face to face interviews with mothers of cases and controls. The data were using descriptive statistical methods, Chi-square and Logistic Regression using STATA 11, calculating odds ratios and condensing P value less than 0.05 as statistically significant. The mean age of the children was 1.9 years and age of their mothers at the time of pregnancy was 28 years. Congenital heart anomalies were the commonest type accounting for 27.5%. Significant risk factors for congenital anomalies were family history (OR=2.24, P= 0.007), maternal obesity (OR= 2.26, P= 0.001), mothers age over 30 (OR=2.78, P= 0.002) and mothers not using folic acid during pregnancy (OR=2.12, P= 0.0007). In general, in order to control and prevent the cases of CM, it is important to provide health education and policies to reduce environmental and maternal risk factors. Further, studies with larger sample size are needed to investigate incidence and risk factors of congenital anomalies.

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Major Congenital Malformations in Barbados: The Prevalence, the Pattern, and the Resulting Morbidity and Mortality

Cited by 34 publications

References 20 publications

Morbidity profile of children referred to Genetic Unit of Mansoura University Childrens Hospital, Egypt.

Morbidity profile of children referred to Genetic Unit of Mansoura University Childrens Hospital, Egypt.

Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China

A Case-Control Study for Assessing Risk Factors for Congenital Anomalies among Children in Sulaimani City

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