Major Contributions towards Finding a Cure for Cancer through Chemotherapy: A Historical Review

Masood, Imran; Kiani, Maria Hassan; Ahmad, Mahmood; Masood, M I; Sadaquat, Hadia

doi:10.5301/tj.5000387

Cited by 25 publications

(33 citation statements)

References 93 publications

(121 reference statements)

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“…In conclusion, our results indicated that the administration of intraperitoneal mitomycin C, doxorubicin, cisplatin, and oxaliplatin in hyperthermic conditions did not decrease the anastomotic bursting pressure. Our observations support the importance of preclinical studies in appropriate experimental models to optimize the use of chemotherapy, which widely contributes to the cure of cancer, in spite of the advent of targeted agents (47).…”

Section: Discussionsupporting

confidence: 77%

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The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

Aghayeva

Benlice

Bilgin

et al. 2017

Tumori

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Introduction Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model. Methods Sixty Wistar albino rats were employed in the study. Sigmoid resection and end-to-end colorectal anastomosis was performed in all rats. Group 1 rats underwent the surgical procedure alone, while group 2 rats were given hyperthermic intraperitoneal lavage with heated saline following surgery. Groups 3, 4, 5, and 6 had surgery with concomitant HIPEC treatment with mitomycin C, cisplatin, oxaliplatin, and doxorubicin, respectively. Anastomotic bursting pressures and hydroxyproline levels were evaluated. Results Regarding the hydroxyproline levels, groups 1 and 2 showed significantly higher values than other groups (p<0.001). However, there was no significant difference between the HIPEC treatment groups (groups 3, 4, 5, and 6) (p>0.05). When groups were compared regarding bursting pressure values, no significant differences were observed (p = 0.81). Conclusions This study demonstrated that the HIPEC procedure with mitomycin C, cisplatin, oxaliplatin and doxorubicin had negative effects on hydroxyproline levels, but had no detrimental effect on anastomotic bursting pressure in a rat model.

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Section: Discussionsupporting

confidence: 77%

“…Our observations support the importance of preclinical studies in appropriate experimental models to optimize the use of chemotherapy, which widely contributes to the cure of cancer, in spite of the advent of targeted agents (47 …”

Section: Discussionsupporting

confidence: 58%

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

Aghayeva

Benlice

Bilgin

et al. 2017

Tumori

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“…In the early 1900s, Paul Ehrlich started to develop drugs to treat infectious diseases, introducing the term chemotherapy. In cancer, chemotherapy works by killing or slowing down tumors by targeting dividing cells, yet nonproliferating cells are often left behind [31]. The most common drugs, nitrogen mustards, and platinum agents represent more than half of the approximately 4000 open clinical trials using DNA crosslinking agents worldwide.…”

Section: Cancer Stem Cells and Resistance To Therapymentioning

confidence: 99%

Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics

Bighetti‐Trevisan

Sousa

Castilho

et al. 2019

Stem Cells International

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A frequent observation in several malignancies is the development of resistance to therapy that results in frequent tumor relapse and metastasis. Much of the tumor resistance phenotype comes from its heterogeneity that halts the ability of therapeutic agents to eliminate all cancer cells effectively. Tumor heterogeneity is, in part, controlled by cancer stem cells (CSC). CSC may be considered the reservoir of cancer cells as they exhibit properties of self-renewal and plasticity and the capability of reestablishing a heterogeneous tumor cell population. The endowed resistance mechanisms of CSC are mainly attributed to several factors including cellular quiescence, accumulation of ABC transporters, disruption of apoptosis, epigenetic reprogramming, and metabolism. There is a current need to develop new therapeutic drugs capable of targeting CSC to overcome tumor resistance. Emerging in vitro and in vivo studies strongly support the potential benefits of combination therapies capable of targeting cancer stem cell-targeting agents. Clinical trials are still underway to address the pharmacokinetics, safety, and efficacy of combination treatment. This review will address the main characteristics, therapeutic implications, and perspectives of targeting CSC to improve current anticancer therapeutics.

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“…Cancer is one of the leading death causes in the world, with 9.6 million deaths evaluated in 2018 25 . Although enormous progress has been made in the treatment of cancer, 26 relapses linked to treatment resistance are often observed 27 . Despite the plant E. arenarium Guss was used in traditional medicine as a potent anti‐inflammatory and anti‐tumor agent, there was still little in‐depth research on the potential antitumor activities of this plant.…”

Section: Discussionmentioning

confidence: 99%

Hydromethanolic root and aerial part extracts from Echium arenarium Guss suppress proliferation and induce apoptosis of multiple myeloma cells through mitochondrial pathway

Limam

Aissa-Fennira

Chahbi

et al. 2021

Environmental Toxicology

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Echium arenarium Guss is a Mediterranean plant traditionally used in healing skin wound and it was reported exhibiting potent antioxidant, antibacterial, and antiparasitic activities. However, antitumoral activities of this plant have not yet been explored. Here we investigated for the first time, root (EARE) and aerial part (EAAPE) extracts of E. arenarium Guss to examine cytotoxicity and apoptosis activation pathway on U266 human multiple myeloma (MM) cell line. We demonstrated that EARE and EAAPE decreased U266 cell viability in a dose dependent manner. Based on 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay, EARE was significantly two times more efficient (IC50 value 41 μg/ml) than EAAPE (IC50 value 82 μg/ml) considering 48 h of treatment. Furthermore, after 24 h of exposure to 100 μg/ml of EARE or EAAPE, cell cycle showed remarkable increase in sub‐G1 population and a decrease of U266 cells proportion in G1 phase. In addition, EARE increased cell percentage in S phase. Moreover, analysis revealed that EAAPE or EARE induced apoptosis of U266 cells after 24 h of treatment. Interestingly, depolarization of mitochondrial membrane potential and activation of caspase 3/7 were demonstrated in treated U266 cells. Phytochemical analysis of E. arenarium extracts showed that EARE exhibited the highest content of total phenolic content. Interestingly, six phenolic compounds were identified. Myricitrin was the major compound in EARE, followed by luteolin 7‐O‐glucoside, resorcinol, polydatin, Trans‐hydroxycinnamic acid, and hyperoside. These findings proved that an intrinsic mitochondria‐mediated apoptosis pathway probably mediated the apoptotic effects of E. arenarium Guss extracts on U266 cells, and this will suggest several action plans to treat MM.

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Major Contributions towards Finding a Cure for Cancer through Chemotherapy: A Historical Review

Cited by 25 publications

References 93 publications

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

Cancer Stem Cells: Powerful Targets to Improve Current Anticancer Therapeutics

Hydromethanolic root and aerial part extracts from Echium arenarium Guss suppress proliferation and induce apoptosis of multiple myeloma cells through mitochondrial pathway

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