Major Depression and Bipolar Disorder: The Concept of Symmetry Breaking

Cocchi, Massimo; Gabrielli, Fabio; Pessa, Eliano; Pregnolato, Massimo; Tonello, Lucio; Zizzi, Paola

doi:10.14704/nq.2012.10.4.577

Cited by 11 publications

(8 citation statements)

References 23 publications

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“…The molecular similarities, observed between animal and man, as concerns the conditions of Major Depression and Bipolar Disorder (Figure 4) suggest that the modulation of serotonin uptake, modified by the viscosity of cell membrane (neuron and platelet), can be considered a mechanism related to evolution [35][36][37][38][39].…”

Section: The Consciousness: a Pathway From Animal To Manmentioning

confidence: 99%

Molecular Contiguity between Human and Animal Consciousness through Evolution: Some Considerations

Cocchi

Gabrielli²,

Tonello³

et al. 2013

J Phylogen Evolution Biol

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This work suggests the possibility of the existence of contiguity in the molecular evolution of consciousness, between man and animal. From the experimental point of view and in terms of hypotheses, it seems that many elements lead to considerations about a common molecular evolutionary origin of the consciousness in animals and humans. It seems, also, evident that the increasing levels of complexity of consciousness can correspond to the evolutionary process. The work discusses a scientific speculation about the possible role of serotonin and thermoregulation in the evolution of consciousness of living beings.

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Section: The Consciousness: a Pathway From Animal To Manmentioning

confidence: 99%

Molecular Contiguity between Human and Animal Consciousness through Evolution: Some Considerations

Cocchi

Gabrielli²,

Tonello³

et al. 2013

J Phylogen Evolution Biol

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“…Looking at the location of the data over the SOM, we find also a region (extreme left corner) which we attribute to psychotic subjects according to the clinical diagnosis. We translated these facts in terms of symmetry breaking [16), confirming that MD is a disease completely trapped apart from healthy, bipolar, psychotic subjects and patients with obsessive compulsive disorder (OCD) ( Figure 9).…”

Section: On the Non-manipulability Of The Som Built For The Classificmentioning

confidence: 64%

The Molecular and Quantum Approach to Psychopathology and Consciousness — From Theory to Experimental Practice

Cocchi¹,

Tonello²,

Gabrielli³

2015

Major Depressive Disorder - Cognitive and Neurobiological Mechanisms

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With the idol of certainty […] there falls one of the defences of obscurantism […] for the worship of this idol hampers not only the boldness of the questions, but also the rigor and the integrity of our tests. The wrong view of science betrays itself in the craving to be right; for it is not its possession of knowledge […] that makes the man of science, but its persistent and recklessly critical quest for truth.(K.R.Popper, The Logic of Scientific Discovery, engl. tr. Hutchinson, London 1959) Recently some major events have allowed a movement of thought not only innovative, but of profound and insistent criticism, mainly at a high intellectual and scientific level, on the

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“…Some powerful contributions of the QPP group (Woolf et al, 2010;Pylkkänen, 2010;Zizzi & Pregnolato, 2012;Mender, 2013), and especially of the Q-NeMoMa Research done by Cocchi's, Gabrielli's and Tonello's group (Cocchi et al 2011;Cocchi et al 2013a;Cocchi et al 2013b;Cocchi et al 2015a;Cocchi et al 2015b;Tonello et al 2015) aimed at defining the experimental procedures to identify molecular modifications of neurons according to changes in neuronal membrane viscosity (quantum and molecular computation), opens new important perspectives for the treatment of mood disorders (Major Depression and Bipolar Disorder), while raising, in the meantime, the issue of finding the most suitable interpretative and applicative ethics.…”

Section: Resultsmentioning

confidence: 99%

Quantum Paradigms of Psychopathology: From Consciousness to Neuroethics

Cocchi¹,

Tonello²,

Gabrielli³

2017

OJD

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The present work deals with the complexity of the arguments underlying the meaning of the quantum paradigm of psychopathology. In particular, the quantum approach to the understanding of the brain and consciousness, seems to present convergence of thinking of many scientists and also seems to be the most promising way in the approach of future research. The practical potency of classical neuroscience directed toward either beneficial or perverse purposes will prove in the end limited by that orthodox paradigm's inherently poor explanatory power in linking mind and brain, especially at the basic level of the Hard Problem as Chalmers (1995) has termed. However, if quantum neurobiology should demonstrate greater explanatory power than does its classical counterpart, then an enhanced potential not only for constructive psychiatric application but also for politically motivated abuse will follow with a vengeance. If the mechanistic-reductionist cognitive approaches have been characterised by the metaphor of the "edifice", of the solid Cartesian rock, all the forms of knowledge founded on complexity theory, have been characterised by the metaphor of the "network", of thinking in relationships, in a dynamic, fluid, open manner. In the field of mental illness, this means setting aside both the organicist paradigm and the pseudo-phenomenological, "sentimental", and therefore ideological, paradigm, in order to have an integrated view of biological objectiveness and humanistic psychotherapy. That is to say, an expression of diverse interrelated contributions from the various disciplines (psychiatry, psychology, biochemistry, anthropology, quantum physics, mathematics, philosophy). The observer thus becomes a builder of models, a manager of complexity, giving treatment the character of a truly empathic relationship. This is all the more so where distressing pathologies are involved, such as Major Depression (MD) and Bipolar Disorder (BD), caput mortuum of psychiatry, because the absence of cogent biological markers seriously compromises every form of therapy.

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Major Depression and Bipolar Disorder: The Concept of Symmetry Breaking

Cited by 11 publications

References 23 publications

Molecular Contiguity between Human and Animal Consciousness through Evolution: Some Considerations

Molecular Contiguity between Human and Animal Consciousness through Evolution: Some Considerations

The Molecular and Quantum Approach to Psychopathology and Consciousness — From Theory to Experimental Practice

Quantum Paradigms of Psychopathology: From Consciousness to Neuroethics

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