Major depression and electrovestibulography

Lithgow, Brian; Garrett, Amber; Moussavi, Zahra; Gurvich, Caroline; Kulkarni, Jayashri; Maller, Jerome Joseph; Fitzgerald, Paul B.

doi:10.3109/15622975.2015.1014410

Cited by 28 publications

(42 citation statements)

References 38 publications

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“…5), as this corresponded to about 100 ms (10 Hz) and both the low end of the vestibular efferent spontaneous rate and α-band activity. This measure has been previously hypothesized to represent an efferent effect on spontaneous afferent activity [12]. In Figure 5, we see that the menses response is shifted to the right compared to in the follicular and luteal phases.…”

Section: Resultsmentioning

confidence: 64%

“…In Figure 5, we see that the menses response is shifted to the right compared to in the follicular and luteal phases. This is similar to what is seen in depression [12]. Feature 2 was formed by taking the sum of IH bins 66, 75, and 84, and subtracting the sum of IH bins 102, 111, and 120.…”

Section: Resultsmentioning

confidence: 99%

“…An IH was formed from the detected and stored FP occurrence times. Every 33rd FP gap was plotted [12] (Fig. 5), as this corresponded to about 100 ms (10 Hz) and both the low end of the vestibular efferent spontaneous rate and α-band activity.…”

Section: Resultsmentioning

confidence: 99%

“…EVestG is a technique designed to detect specific vestibulo-acoustic (and arguably, mostly vestibular) field potentials (FPs) [17, 18], potentially providing a quantitative indirect measure of activity in the brain regions and neural pathways that are frequently compromised in neuropsychiatric diseases like depression [12]. To minimize movement artifacts, the EVestG measures that we used were recorded only from spontaneous neural activity (hypothesized to be generated predominantly in the vestibular periphery [18]) and not in response to any direct body tilt stimuli [17].…”

Section: Methodsmentioning

confidence: 99%

“…Electrovestibulography (EVestG) recordings were previously applied toward classifying and/or measuring the severity of depression with and without anxiety [12]. EVestG features accurately classified major depressive disorder (MDD) and healthy (a leave-one-out cross-validated accuracy of 87%) as well as symptomatic (a Montgomery-Ǻsberg Depression Rating Scale [MADRS] score of > 18) versus reduced symptomatic (MADRS ≤19) depression (a leave-one-out cross-validated accuracy of 77%).…”

Section: Introductionmentioning

confidence: 99%

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Physiological Differences in the Follicular, Luteal, and Menstrual Phases in Healthy Women Determined by Electrovestibulography: Depression, Anxiety, or Other Associations?

Lithgow

Moussavi

2017

Neuropsychobiology

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Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study’s objectives were to: (1) extract EVestG features representing physiological differences of healthy women during their menses, and follicular and luteal phases of their menstrual cycle, and (2) compare these features to those observed in previous studies for depression with and without anxiety. Three EVestG recordings were made on 15 young healthy menstruating females during menses, and follicular and luteal phases. Three features were extracted, using the shape and timing of the detected spontaneously evoked vestibulo-acoustic field potentials. Using these features, a 3-way separation of the 3 phases was achieved, with a leave-one-out cross-validation, resulting in accuracy of > 72%. Using an EVestG shape feature, separation of the follicular and luteal phases was achieved with a leave-one-out cross-validation accuracy of > 93%. The mechanism of separation was not like that in previous depression analyses, and is postulated to be more akin to a form of anxiety and/or progesterone sensitivity.

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Section: Resultsmentioning

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physiological Differences in the Follicular, Luteal, and Menstrual Phases in Healthy Women Determined by Electrovestibulography: Depression, Anxiety, or Other Associations?

Lithgow

Moussavi

2017

Neuropsychobiology

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Verification EVestG recordings are vestibuloacoustic signals

Blakley

Ashiri

Moussavi

et al. 2022

Laryngoscope Investig Oto

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Introduction: Neural dysfunction is associated with aberrant nerve firing; thus, electrodiagnosis has the potential for objective diagnosis and quantification of neural dysfunction. Electrical stimulation alters nerve firing and may also have treatment potential. This article outlines some findings related to electrodiagnosis and electrical stimulation of the ear. The quasi-synchronous firing of many vestibuloacoustic nerve fibers can produce an extracellular potential defined as a field potential (FP). Electrovestibulography (EVestG) is a method to record vestibuloacoustic signals and detect the associated FPs. A clear picture of the muscle-, EEG-, saccade-related, or other artefactual origins, and the physiologic basis of FPs recorded with EVestG, is evolving. EVestG was applied to demonstrate the effect of electrical stimulation on spontaneous FPs in the ear canal.Methods: Bilateral EVestG recordings were conducted on 14 guinea pigs before and after stimulation with 3-0.5 mA ipsilateral anodal electrical pulses before and after ablation via unilateral Scarpa's ganglionectomy to elucidate the origin of the EVestG recorded spontaneous FPs.Results: Anodal electrical stimulation suppresses the recorded activity. There was a significant reduction of the level of recorded signal observed following anodal stimulation on the ablated but not the intact side. Conclusion:Electrical stimulation of the external auditory canal reduces spontaneous electrical activity in the ear canal, some of which is due to central nervous system activity. The EVestG recorded FPs have a major vestibuloacoustic component.

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Some Basic Science and Functional Illness

Blakley

Bosecke²

2023

Functional Illness of the Head and Neck

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Major depression and electrovestibulography

Cited by 28 publications

References 38 publications

Physiological Differences in the Follicular, Luteal, and Menstrual Phases in Healthy Women Determined by Electrovestibulography: Depression, Anxiety, or Other Associations?

Physiological Differences in the Follicular, Luteal, and Menstrual Phases in Healthy Women Determined by Electrovestibulography: Depression, Anxiety, or Other Associations?

Verification EVestG recordings are vestibuloacoustic signals

Some Basic Science and Functional Illness

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