Major depressive disorder

Giannelli, Frank

doi:10.1097/01.jaa.0000657208.70820.ab

Cited by 9 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in daylight interfere with the phase-synchronization between individual neurons, which causes physiological and biochemical disruptions that impact mental health [ 53 ]. Inherently, women are more prone to disturbances in the circadian rhythm than men [ 54 ], which make them more susceptible to major depressive disorders with a seasonal pattern [ 55 , 56 ]. Timing of clock gene rhythms in the brain [ 57 ], diurnal body temperature regulation, production of melatonin and duration of sleep cycles tend to be shorter or occur at earlier stages in women [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Diet, Exercise, Lifestyle, and Mental Distress among Young and Mature Men and Women: A Repeated Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

Customization of mental health therapies needs to consider the differences in degree of brain maturity between young (18–29 years) and mature (30 years or older) adults as well as brain morphology among men and women. The aim of this study was to identify the significant dietary and lifestyle contributors to mental distress in these sub-populations. Independent repeated cross-sectional sampling was performed for over a 5-year period (2014–2019) to collect data from different populations at different time-points and seasons. A backward stepwise regression analysis was used on 2628 records. Mental distress in young women was associated with high consumption of caffeine and fast-food, and it was negatively correlated with moderate-high levels of exercise as well as frequent breakfast consumption. Mature women shared several common factors with young women; however, high fruit consumption was negatively associated with mental distress. For young men, high exercise, moderate consumption of dairy, and moderate-high intake of meat were negatively associated with mental distress. In addition, high fast-food and caffeine consumption were positively associated with mental distress in young men. For mature men, strong negative associations between higher education, moderate intake of nuts and mental distress surfaced. Our results support the need to customize dietary and lifestyle recommendations to improve mental wellbeing.

show abstract

Section: Discussionmentioning

confidence: 99%

Diet, Exercise, Lifestyle, and Mental Distress among Young and Mature Men and Women: A Repeated Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Only 85.0% accepted that major depression could be treated with pharmacology and psychotherapy [11]. Where the adolescents understood and were aware that major depression can be treated and changes in the behaviour or using drugs or alcohol could be signs and symptoms of [12,13].…”

Section: Comparison Of the Knowledge Level On Depression At Pre-inter...mentioning

confidence: 99%

“…The majority of the respondents correctly reported lack of pleasure, interest, saddening, hopelessness, low mood, lack of concentration, frequent headache, unhappy, irritable and feeling the pressure as symptoms of depression. In a previous study, the same symptoms of depression were listed down by the respondents [12][13][14].…”

Section: Comparison Of the Knowledge Level On Depression At Pre-inter...mentioning

confidence: 99%

Enhancement of Knowledge and Attitude level on Depression via Knowledge, Depression and Adolescents (KDA)Puzzles

Selamat¹,

Gobu

Irwanto³

et al. 2021

Journal of Indian Association for Child and Adolescent Mental H

View full text Add to dashboard Cite

“…It is usually accompanied with persistent feeling of sadness, anhedonia, pain without a clear cause, difficulties in thinking and concentration, loss of interest in doing anything, psychomotor retardation, fatigue, spending time sleeping, feelings of worthlessness or inappropriate guilt, and recurrent thoughts of death. These symptoms cause distress or impairment in social life and are not an effect of the influence of other medical conditions [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. The spectrum of symptoms in individual patients depends on the type of depression and ranges from excessive consumption of chocolate during episodes of seasonal affective disorder to nihilistic delusions of extensive and absurd content characteristic of Cotard syndrome, which is a rare mental disorder in which the affected person holds the delusional belief that they are dead, do not exist, are putrefying, or have lost their blood or internal organs [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.

et al. 2022

View full text Add to dashboard Cite

Psychotropic effect of Crocus sativus L. (family Iridaceae) biologically active chemical compounds are quite well documented and they can therefore be used in addition to the conventional pharmacological treatment of depression. This systematic review on antidepressant compounds in saffron crocus and their mechanisms of action and side effects is based on publications released between 1995–2022 and data indexed in 15 databases under the following search terms: antidepressant effect, central nervous system, Crocus sativus, cognitive impairement, crocin, crocetin, depression, dopamine, dopaminergic and serotonergic systems, picrocrocin, phytotherapy, neurotransmitters, safranal, saffron, serotonin, and biologically active compounds. The comparative analysis of the publications was based on 414 original research papers. The investigated literature indicates the effectiveness and safety of aqueous and alcoholic extracts and biologically active chemical compounds (alkaloids, anthocyanins, carotenoids, flavonoid, phenolic, saponins, and terpenoids) isolated from various organs (corms, leaves, flower petal, and stigmas) in adjuvant treatment of depression and anxiety. Monoamine reuptake inhibition, N-methyl-d-aspartate (NMDA) receptor antagonism, and gamma-aminobutyric acid (GABA)-α agonism are the main proposed mechanism of the antidepressant action. The antidepressant and neuroprotective effect of extract components is associated with their anti-inflammatory and antioxidant activity. The mechanism of their action, interactions with conventional drugs and other herbal preparations and the safety of use are not fully understood; therefore, further detailed research in this field is necessary. The presented results regarding the application of C. sativus in phytotherapy are promising in terms of the use of herbal preparations to support the treatment of depression. This is particularly important given the steady increase in the incidence of this disease worldwide and social effects.

show abstract

Major depressive disorder

Cited by 9 publications

References 0 publications

Diet, Exercise, Lifestyle, and Mental Distress among Young and Mature Men and Women: A Repeated Cross-Sectional Study

Diet, Exercise, Lifestyle, and Mental Distress among Young and Mature Men and Women: A Repeated Cross-Sectional Study

Enhancement of Knowledge and Attitude level on Depression via Knowledge, Depression and Adolescents (KDA)Puzzles

Current Knowledge of the Antidepressant Activity of Chemical Compounds from Crocus sativus L.

Contact Info

Product

Resources

About