This study proposes a bridge safety evaluation process against seismic and flood hazards. 1Because uncertainties in the scours, seismic hazard, and structural performance for a given 2 seismic excitation are inevitable and important, reliability analysis is adopted. A scour 3 prediction equation for a bridge with a complicated foundation system is developed and a 4 probabilistic scour curve is constructed to measure the risk of scours using the Monte Carlo 5 simulation. The seismic hazard is measured using the probabilistic seismic-hazard analysis. A 6 series of nonlinear time-history analyses are performed to determine the structural 7 performance under different peak-ground-acceleration values. SAP2000 is used to build the 8 finite-element model wherein the soil is modeled using a bilinear link. A plastic hinge is 9 predefined to simulate the nonlinear behaviors of the pier and caisson of the bridge. The 10 displacement ductility is used to measure the structural performance and to construct the 11 fragility curve for various limit states. The Nanyun Bridge located in central Taiwan is 12 selected as an example to demonstrate the proposed safety-evaluation procedure. The results 13show that the probable scour depth of the Nanyun bridge is from 3 to 5 m. The failure 14 probability considering the floods and earthquakes is insignificant. A deterministic design 15 value, considering both the hazards, is provided for a given reliability target (e.g., = 3) to 16 help engineers in their present design processes. 17