Major Extracardic Malformations among patients with congenital heart defects

Correia, Jamile Dutra; Rosa, Ernani Bohrer da; Silveira, Daniélle Bernardi; Grapiglia, Carolina Geitens; Canabarro, Simone Travi; Waterkemper, Roberta; Zen, Paulo Ricardo Gazzola; Rosa, Rafael Fabiano Machado

doi:10.1016/j.ijcard.2016.03.120

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…Congenital heart defects are the leading malformations in Zhejiang Province. It has also been reported that CAKUTs are one of the most common defects associated with congenital heart defects [33, 34]. According to published studies, the most frequently reported nonurinary anomalies involve the genitourinary tract; central nervous system, musculoskeletal, digestive and cardiovascular systems, and chromosomal anomalies [2, 5, 11].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study

Chen

et al. 2019

Ital J Pediatr

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Background Congenital anomalies of the kidney and urinary tract (CAKUTs) are some of the most common birth defects affecting newborns. CAKUTs often have poor birth outcomes owing to the limited experience of physicians in developing countries regarding antenatal and postnatal diagnosis. We aimed to estimate the epidemiology of CAKUTs using data from a hospital-based registry in Zhejiang Province, China. Methods We included a total of 2790 newborns with CAKUTs, identified among 1,748,038 births during 2010–2016. The prevalence and type of CAKUTs, maternal and neonatal characteristics, and associated malformations were analyzed. Results The average prevalence of CAKUTs born to mothers overall and mothers aged ≥35 years were both around 1.60 per 1000 births (95% confidence interval (CI), 1.54–1.66; 95% CI, 1.44–1.83, respectively) during the study period. The prevalence of CAKUTs changed over time among all women and women of advanced maternal age, although no significant trends were observed. CAKUTs were more likely to occur in male than female newborns (odds ratio (OR) 1.28, 95% CI 1.18–1.38), in multiple births than singletons (OR 1.53, 95% CI 1.21–1.92) and in urban areas than rural areas (OR 1.27, 95% CI 1.18–1.37). The overall prenatal detection rate of CAKUTs was 73.87%. The average gestational age at antenatal diagnosis was 26.57 ± 8.70 weeks. A total 22.69% CAKUTs had associated malformations. Congenital heart defects were the most common anomalies, accounting for 8.89% of the whole population. The main proportion in subgroups was hydronephrosis, representing 31.79% of registered CAKUTs. Conclusions There was a nearly twofold increase in the prevalence of CAKUTs from 2010 to 2016 in Zhejiang Province. CAKUTs are strongly associated with male sex, multiple births, urban areas, and other nonurinary congenital malformations.

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Section: Discussionmentioning

confidence: 99%

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study

Chen

et al. 2019

Ital J Pediatr

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“…The only inclusion criteria was admission in the Pediatric ICU for cardiac reasons, while patients with non-cardiac motives were excluded. These patients were also previously described in other studies [11][12][13][14].…”

Section: Methodsmentioning

confidence: 88%

Influence of Congenital Heart Defect Types over Cardiopulmonary Bypass, Aortic Cross-Clamping, and Intensive Care Unit Length of Stay and Their Association with Genetic Factors

Silva,

Telles,

Correia

et al. 2023

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Aim: Surgical correction of congenital heart defects (CHD) often requires interruption of blood flow through cardiopulmonary bypass (CPB) and aortic cross-clamping (ACC), for which duration(s) are considered to be prognostic factors, along with intensive care unit (ICU) length of stay (ICULOS). The aim of this study was to evaluate these surgical prognostic factors in pediatric patients with different types of CHD regarding their type of lesion and associated genetic factors. Study Design: Cross-sectional cohort study with 307 pediatric patients. Place and Duration of Study: Pediatric Intensive Care Unit (ICU) of Hospital da Criança Santo Antônio, in Porto Alegre/RS, Brazil, from 2006-2009 (3 years) Methodology: After inclusion criteria, we studied 266 pediatric patients admitted for the first time in a reference cardiac pediatric ICU from Southern Brazil following cardiac surgery. Intraoperative prognostic factors such as duration of CPB, ACC and ICULOS, in addition to dysmorphological and cytogenetic examinations were compiled and analyzed. P-values of <0.05 were considered significant. Results: CPB time was associated to four outflow tract defects (Tetralogy of Fallot [ToF], transposition of the great arteries [TGA], double outlet right ventricle, and truncus arteriosus [TA]), atrioventricular septal defect, and hypoplastic left heart syndrome (HLHS) (P < 0.001). ACC duration was associated with three outflow tract defects (ToF, TGA, and TA) and HLHS (P < 0.001). Moreover, CPB and ACC times showed an association with cyanotic and complex heart defects, as well as prolonged ICULOS (P < 0.001). There was no relationship between these prognostic factors and syndromic aspects or cytogenetic findings. Conclusions: CHD type has an impact over CPB and ACC duration and ICULOS, whereas genetic factors are not associated with those prognostic factors.

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“…While prior studies have evaluated the incidence of ECM after the diagnosis of CHD, which varies from 20% to 45%, 2–8 we examined the reverse scenario: the incidence of CHD after the diagnosis of ECM in utero. Not surprisingly, we found different incidences, ranging from 9.8% to 35.1%, based on the organ system involved.…”

Section: Discussionmentioning

confidence: 99%

“…Congenital heart disease (CHD) is the most common birth defect with an incidence of 8.8 to 10.4 per 1000 live births 1 . Up to 50% of fetuses and infants with CHD have a coexisting extracardiac malformation (ECM), 2–8 which can impact morbidity and mortality 6,9 . This recognition has prompted neonatal screening for ECMs when CHD is diagnosed, 10–12 as well as the referral for a comprehensive obstetric anatomy sonogram after the prenatal detection of CHD 13…”

Section: Introductionmentioning

confidence: 99%

The role of fetal echocardiogram after detection of extracardiac anomalies in utero (fetal echocardiogram for extracardiac malformations)

et al. 2021

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Objective We aimed to investigate the utility of comprehensive screening fetal echocardiography (FE) for patients diagnosed with any type of fetal extracardiac malformation (ECM) at a single multidisciplinary fetal center. Methods We retrospectively reviewed all patients presenting to our referral center for FE due to a prenatal diagnosis of ECM (January 2013–December 2018). Results Among 641 patients with ≥1 ECM referred for FE, 78 (12.2%) had CHD diagnosed at 25.6 ± 0.5 weeks. The frequency of CHD by type of ECM ranged from 35.1% for craniofacial to 9.8% for thoracic. Increasing number of fetal ECMs was strongly associated with CHD: odds ratio 2.01 (95% confidence interval: 1.06–3.69) for two ECMs, 9.57 (2.00–49.05) for three ECMs, and 11.68 (3.84–37.15) for more than three ECMs. Of fetuses with ECM and an abnormal genetic finding, 33.3% had CHD as compared to 10.9% of those without (p < 0.0001). Obstetric anatomy sonogram detected 43.6% of CHD. Conclusion CHD was commonly diagnosed among fetuses with any type of ECM at our center but was not always detected on obstetric sonogram. As the presence of CHD may impact decision‐making and perinatal care, patients with a diagnosis of any fetal ECM should be considered for FE.

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Major Extracardic Malformations among patients with congenital heart defects

Cited by 7 publications

References 7 publications

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study

Influence of Congenital Heart Defect Types over Cardiopulmonary Bypass, Aortic Cross-Clamping, and Intensive Care Unit Length of Stay and Their Association with Genetic Factors

The role of fetal echocardiogram after detection of extracardiac anomalies in utero (fetal echocardiogram for extracardiac malformations)

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