Major hepatectomy for isolated metastases from gastric adenocarcinoma

Abstract

Despite some anecdotal reports of treatment with chemotherapy, either systemic or intrahepatic, the more consistent results for the treatment of patients with hepatic metastases from gastric adenocarcinoma come from the Japanese literature with the use of radical surgery. Unfortunately, Western series, including our own, do not achieve the same results. At the present time, in view of these results, we are performing less aggressive treatment such as radio-frequency ablation.

Surgical management of noncolorectal cancer liver metastases

“…22 Historically, hepatic resection for synchronous gastric cancer metastases was associated with a poor median survival of only 5-8 months and a 5-year survival of less than 10%-20%. 23,24 Given this, the clinical benefit of hepatic resec-tion for stage IV gastric cancer has not been widely accepted. [25][26][27] In 1 study, Okano et al examined 90 patients with gastric cancer who had synchronous (n 78) or metachronous (n 5 12) hepatic metastases.…”

“…In the setting of gastric cancer, only 0.5%‐10% of patients with hepatic metastases will have technically resectable disease in the absence of extrahepatic disease . Historically, hepatic resection for synchronous gastric cancer metastases was associated with a poor median survival of only 5‐8 months and a 5‐year survival of less than 10%‐20% . Given this, the clinical benefit of hepatic resection for stage IV gastric cancer has not been widely accepted .…”

Surgical treatment of liver metastases of gastric cancer: is local treatment in a systemic disease worthwhile?

“…Furthermore, very few patients with GHM are good candidates for liver surgery because most patients have multiple, scattered, bilobar lesions 9 . Patients with isolated metastases are unusual and accounted for 0.5% of patients in a series reported by Linhares et al 10 . Baba et al .…”

Resección de metástasis hepáticas en cáncer gástrico: Experiencia preliminar

“…Lo ideal es tener un paciente con metástasis única hepática. Sin embargo, esta situación ocurre sólo en menos del 1% según estudios internacionales 9 . En nuestra experiencia, de 100 pacientes con cáncer gástrico y metástasis hepáticas, sólo 2 tienen metástasis única (estudio no publicado).…”