2019
DOI: 10.1101/753970
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Major histocompatibility complex class I-restricted protection against murine cytomegalovirus requires missing-self recognition by the natural killer cell inhibitory Ly49 receptors

Abstract: 16Viruses have evolved strategies that highlight critical, intertwined host immune mechanisms. As 17 postulated by the missing-self hypothesis, natural killer (NK) cells and major histocompatibility complex 18 class I (MHC-I)-restricted cytotoxic T lymphocytes (CTLs) have opposing requirements for ubiquitously 19 expressed MHC-I molecules. Since NK cell MHC-I-specific Ly49 inhibitory receptors prevent killing of cells 20 with normal MHC-I, viruses evading CTLs by down-regulating MHC-I should be vulnerable to N… Show more

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“…The distribution of these subsets among the cNK and trNK differs significantly. Inhibitory receptors such as human killer immunoglobulin-like inhibitory receptors (KIR) [ 60 ] and murine Ly49s [ 61 ] primarily recognize classical Major Histocompatibility Complex Class I (MHC-I) and form the basis for ‘licensing’ that allows NK cells to differentiate between ‘self’ and ‘non-self’ [ 5 , 6 , 7 , 8 , 9 ]. Notably, cNK and trNK cells express differing levels or types of KIRs, emphasizing the potential divergent effector functions of these subsets.…”
Section: Introductionmentioning
confidence: 99%
“…The distribution of these subsets among the cNK and trNK differs significantly. Inhibitory receptors such as human killer immunoglobulin-like inhibitory receptors (KIR) [ 60 ] and murine Ly49s [ 61 ] primarily recognize classical Major Histocompatibility Complex Class I (MHC-I) and form the basis for ‘licensing’ that allows NK cells to differentiate between ‘self’ and ‘non-self’ [ 5 , 6 , 7 , 8 , 9 ]. Notably, cNK and trNK cells express differing levels or types of KIRs, emphasizing the potential divergent effector functions of these subsets.…”
Section: Introductionmentioning
confidence: 99%