Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms: Associated with Susceptibility to Kawasaki Disease and Coronary Artery Aneurysms

Hsieh, Yao Yuan; Chang, Chi Chen; Chen, Shih Yin; Lin, Wen-Hsin; Tsai, Fuu Jen

doi:10.1089/gtmb.2011.0001

Cited by 16 publications

(9 citation statements)

References 39 publications

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“…Past reports on the allelic distribution of MICB were of little information with regard to disease. A growing body of research now shows that MICB polymorphism is related to certain diseases . However, as HLA‐MICB‐MICA haplotypes have been reported in different people , this disease association may be secondary and due to LD with HLA alleles.…”

Section: Mica Allele Frequencies In Hainan LI Populationmentioning

confidence: 99%

“…A growing body of research now shows that MICB polymorphism is related to certain diseases . However, as HLA‐MICB‐MICA haplotypes have been reported in different people , this disease association may be secondary and due to LD with HLA alleles. Some reported MICA‐MICB haplotypes were confirmed in our study, for example, MICB*005:02 was in strong LD with MICA*010 , and MICB*008 displayed distinct LD patterns with MICA*002:01 in the Li population.…”

Section: Mica Allele Frequencies In Hainan LI Populationmentioning

confidence: 99%

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MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

et al. 2014

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Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Li population of 344 unrelated individuals. By using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequence-based typing (PCR-SBT), 17 MICA-sequence alleles and 5 MICA-STR (short tandem repeats, STR) alleles, as well as 17 MICB alleles were detected, among which MICA*010, MICA*A4 and MICB*005:02 were the most frequent alleles. In addition, linkage disequilibrium was investigated and the most common two-locus haplotypes were MICB*005:02-MICA*010 and MICB*008-MICA*002:01. These results present informative genetic markers for the investigation of possible origins and the evolution of MHC class I haplotypes in the Li population.

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Section: Mica Allele Frequencies In Hainan LI Populationmentioning

confidence: 99%

Section: Mica Allele Frequencies In Hainan LI Populationmentioning

confidence: 99%

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

et al. 2014

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“…In siblings of affected children it is 10 to 15-fold higher than the population incidence [18] and familial occurrence is described [19]. These observations suggest that disease susceptibility may be influenced by genetic and cultural factors [20]. …”

Section: Introductionmentioning

confidence: 99%

Kawasaki disease in children and adolescents: clinical data of Kawasaki patients in a western region (Tyrol) of Austria from 2003–2012

et al. 2014

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BackgroundKawasaki disease (KD) is a rare vasculitis seen predominantly in children. In developing countries, it is the leading cause of childhood-acquired heart disease. Besides a case report from 1981 there have been no data published dealing with the epidemiology and clinical aspects of KD in Austria.MethodsThe purpose of the present study was to investigate the clinical spectrum of KD in a geographically determined cohort of infants, children, and adolescents that were diagnosed and treated at the University Hospital of Innsbruck from 2003–2012.ResultsThirty-two patients were included in the study with a median age of 32.96 months (2–192). 59.4% of the patients were aged between six months and four years. The male-to-female ratio was 1:1.13. Clinical examination revealed non-purulent conjunctivitis and exanthema as the most common symptoms (84.4%). 75% showed oropharyngeal changes, 21.9% had gastrointestinal complaints such as diarrhoe, stomachache or vomiting prior to diagnosis. One third of the patients were admitted with a preliminary diagnosis, whereas 78.1% were pre-treated with antibiotics. The median fever duration at the time of presentation was estimated with 4.96 days (1–14), at time of diagnosis 6.76 days (3–15).75% were diagnosed with complete KD, and 25% with an incomplete form of the disease. There was no significant difference in the duration of fever neither between complete and incomplete KD, nor between the different age groups. Typical laboratory findings included increased C-reactive protein (CRP) (80.6%) and erythrocyte sedimentation rate (ESR) (96%),leukocytosis (48.4%) and thrombocytosis (40.6%) without any significant quantitative difference between complete and incomplete KD. Coronary complications could be observed in six patients: one with a coronary aneurysm and five with tubular dilatation of the coronary arteries. Our patient cohort represents the age distribution as described in literature and emphasizes that KD could affect persons of any age. The frequency of occurrence of the clinical symptoms differs from previous reports – in our study, we predominantly observed non-purulent conjunctivitis and exanthema.ConclusionKD should always be considered as a differential diagnosis in a child with fever of unknown origin, as treatment can significantly decrease the frequency of coronary complications.Electronic supplementary materialThe online version of this article (doi:10.1186/1546-0096-12-37) contains supplementary material, which is available to authorized users.

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“…BAG6 polymorphism is associated with increased incidence of several autoimmune diseases such as Kawasaki syndrome and type I diabetes (Hsieh et al, 2011;Piras et al, 2014). As BAG6 influences numerous substrate proteins essential to immune regulations, it suggests a functional link between BAG6 and autoimmune disorders.…”

Section: The Role Of Bag6 In Autoimmune Diseasementioning

confidence: 99%

The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease

Benarroch

Austin

Ahmed

et al. 2019

Molecular Chaperones in Human Disorders

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Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms: Associated with Susceptibility to Kawasaki Disease and Coronary Artery Aneurysms

Abstract: MICB*rs2516400 polymorphisms and some MHC class I-related haplotypes are associated with KD susceptibility. MICB and MHC class I genetic variations might contribute to the pathogenesis of KD and CAL.

Cited by 16 publications

References 39 publications

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

MIC gene polymorphism and haplotype diversity in Li nationality of Southern China

Kawasaki disease in children and adolescents: clinical data of Kawasaki patients in a western region (Tyrol) of Austria from 2003–2012

The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease

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