Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition

Rapacz-Leonard, A.; Dąbrowska, Małgorzata; Janowski, Tomasz

doi:10.1155/2014/579279

Cited by 24 publications

(21 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Classical MHC are highly polymorphic, and are thus capable of presenting many different types of antigens, including paternal antigens found on invasive trophoblast cells in cattle and horses (Davies et al, 2000;Bacon et al, 2002), although trophoblast cells may also fail to express classical MHC-I molecules containing such paternal antigens. Nonclassical MHC-I proteins express a ''zero'' antigen to evade uterine natural killer cells while being recognized as self antigen by leukocytes (Rapacz-Leonard et al, 2014). MHC-I molecules are generally not expressed from cells of non-invasive regions of the human placenta or in noninvasive trophoblast cells of the placenta in ungulates (Low et al, 1990;Ramsoondar et al, 1999;Bainbridge 2000).…”

Section: Discussionmentioning

confidence: 99%

Differences in mRNA populations of short and long bovine conceptuses on Day 15 of gestation

Barnwell

Farin

Ashwell

et al. 2016

Molecular Reproduction Devel

View full text Add to dashboard Cite

The majority of pregnancy loss in cattle occurs between Days 8 and 16 of gestation, coincident with the initiation of conceptus elongation and the onset of maternal recognition of pregnancy. Differences in conceptus length on the same day of gestation may be related to an inherent lack of developmental competency or may simply be a consequence of asynchrony with the maternal environment. The objective of this work was to characterize differential patterns of mRNA expression between short and long bovine conceptuses recovered on Day 15 of gestation. Embryos were produced from super-ovulated Holstein donor cows, and groups of Grade-1 and Grade-3 compact morulas were transferred into recipient heifers at Day 6.5 of their cycle. Conceptuses were recovered at Day 15 of gestation, and measured to assess overall length and area. Total RNA was extracted and analyzed on individual GeneChip Bovine Genome Arrays (Affymetrix, Santa Clara, CA). Gene expression was compared between conceptuses derived from the transfer of Grade-1 versus Grade-3 embryos; no differences were identified in the profiles of Day-15 conceptuses of these different embryo grades. When gene expression was compared between conceptuses classified as either short (mean length of 4.2 ± 0.1 mm [standard error]) or long (24.7 ± 1.9 mm) upon recovery at Day 15 of gestation, a total of 348 genes were differentially expressed. Of these, 221 genes were up-regulated and 127 were down-regulated in long compared to short conceptuses. In summary, differences in gene expression were identified between conceptuses recovered on Day 15 of gestation, based on their length. These data may be used to identify genes and cellular pathways involved in enhanced conceptus elongation that could serve as markers of successful pregnancy. Mol. Reprod. Dev. 83: 424-441, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Differences in mRNA populations of short and long bovine conceptuses on Day 15 of gestation

Barnwell

Farin

Ashwell

et al. 2016

Molecular Reproduction Devel

View full text Add to dashboard Cite

show abstract

“…Little is known about immunological activity at the feto‐maternal junction during pregnancy, but pro‐inflammatory changes have been reported when paternal antigens are expressed on inter‐placentomal areas of the fetal membranes (Joosten et al, ; Davies et al, ). This maternal‐rejection response could be modulated by the expression of MHC‐I along with paternal antigens at the time of parturition (Rapacz‐Leonard et al, ). We hypothesize that the increased estrogen‐to‐progesterone ratio facilitates this MHC‐I‐dependent inflammatory response, thus driving the process of placentome maturation.…”

Section: Separation and Expulsion Of Fetal Membranesmentioning

confidence: 99%

Cellular and molecular mechanisms involved in placental separation in the bovine: A review

Attupuram

Kumaresan

Narayanan

et al. 2016

Molecular Reproduction Devel

View full text Add to dashboard Cite

SUMMARYRetention of fetal membranes (RFM), where the fetal placenta is not expelled within 8À12 hr after calving, lowers bovine productivity and fertility, resulting in significant economic loss to the dairy industry. Several risk factors that predispose an individual to RFM are known, but a unifying pathogenesis remains elusive due to its multifactorial etiology. Fetal membrane separation and expulsion after parturition involves structural and immunological changes of the bovine placentome that are governed predominantly by steroid hormones and the prostaglandin milieu of late pregnancy and parturition. Maturation of the placentome, a gradual and concerted event of late gestation, is likely initiated by the up-regulation of fetal major histocompatibility complex class I in the interplacentomal regionÀ Àwhich increases the apoptosis of binucleate and other trophoblastic cells, the degradation of collagen in the extracellular matrix by matrix metalloproteinases, and an influx of phagocytic leukocytes. Shear force further distorts the crypt architecture of the mature placentomes when they are forced against the fetus during the second stage of labor. Cotyledon dehiscence from the caruncular crypts is completed following fetal expulsion as a result of acute shrinkage of the cotelydonary villi as well as reduced perfusion to the caruncle; the secundinae is expelled by uterine contractions. A better understanding of placentomal maturation, intra-partum, and immediate postpartum changes of the placentome should help develop strategies for the treatment and prevention of RFM. The present review proposes a model of placentome maturation and separation of fetal membranes in the dairy cow. We hypothesize that the increased estrogen-toprogesterone ratio facilitates [an] MHC-I-dependent inflammatory response, thus driving the process of placentome maturation.

show abstract

“…In humans, certain HLA antigens between couples in closely related populations may lead to infertility and miscarriages [29]. Many studies showed that the sharing of certain maternal-fetal or paternal HLA and BoLA antigens may influence fetal development and survival [29,30]. Similarly, in pigs, the influence of SLA-encoded genes on reproductive performances has been reported as the association between specific SLA haplotypes and genital tract development in males, ovulation rates, litter size, and piglet weight at birth and weaning [3,17,18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs

Andõ

Imaeda

Matsubara

et al. 2019

Cells

View full text Add to dashboard Cite

The effects of swine leukocyte antigen (SLA) molecules on numerous production and reproduction performance traits have been mainly reported as associations with specific SLA haplotypes that were assigned using serological typing methods. In this study, we intended to clarify the association between SLA class II genes and reproductive traits in a highly inbred population of 187 Microminipigs (MMP), that have eight different types of SLA class II haplotypes. In doing so, we compared the reproductive performances, such as fertility index, gestation period, litter size, and number of stillbirth among SLA class II low resolution haplotypes (Lrs) that were assigned by a polymerase chain reaction-sequence specific primers (PCR-SSP) typing method. Only low resolution haplotypes were used in this study because the eight SLA class II high-resolution haplotypes had been assigned to the 14 parents or the progenitors of the highly inbred MMP herd in a previous publication. The fertility index of dams with Lr-0.13 was significantly lower than that of dams with Lr-0.16, Lr-0.17, Lr-0.18, or Lr-0.37. Dams with Lr-0.23 had significantly smaller litter size at birth than those with Lr-0.17, Lr-0.18, or Lr-0.37. Furthermore, litter size at weaning of dams with Lr-0.23 was also significantly smaller than those dams with Lr-0.16, Lr-0.17, Lr-0.18, or Lr-0.37. The small litter size of dams with Lr-0.23 correlated with the smaller body sizes of these MMPs. These results suggest that SLA class II haplotypes are useful differential genetic markers for further haplotypic and epistatic studies of reproductive traits, selective breeding programs, and improvements in the production and reproduction performances of MMPs.

show abstract

Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition

Cited by 24 publications

References 83 publications

Differences in mRNA populations of short and long bovine conceptuses on Day 15 of gestation

Differences in mRNA populations of short and long bovine conceptuses on Day 15 of gestation

Cellular and molecular mechanisms involved in placental separation in the bovine: A review

Genetic Association between Swine Leukocyte antigen Class II Haplotypes and Reproduction Traits in Microminipigs

Contact Info

Product

Resources

About