Major Histocompatibility Complex (MHC) and Peptide Binding

Clinical management of patients with thymic epithelial tumors: the recommendations endorsed by the Italian Association of Medical Oncology (AIOM)

“…1,2 Such ethnic differences in incidence rates could suggest a potential role for genetic factors in the pathogenesis of TETs. 3 In the last few years, major findings in the biology of TETs support the hypothesis that the different histological subtypes are distinct biological entities, with peculiar molecular and genomic alterations, rather than a continuum spectrum of a unique disease. [4][5][6] Whole-exome sequencing analysis allowed to identify several recurrent molecular aberrations, including GTF2I gene mutation, occurring in 39% of cases, mainly in type A (82%) and AB thymomas (TMs).…”