Major malformations of the Central Nervous System as seen at The University Teaching Hospital, Ilorin

Odebode, O T; Adeniran, J A

doi:10.4314/njp.v32i3.12116

Cited by 2 publications

(6 citation statements)

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“…[325] From the current study, musculoskeletal anomalies (talipes equinovarus) particularly were found to be the most common associated systemic anomaly. A male preponderance was observed in the study population similar to previous reports[2226] whereas other workers have reported equal sex distribution. [25] However, the probable reason for the higher male predilection in the present study appears uncertain.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, low schooling and low socioeconomic class among the caregivers could be a reason for the lack of accessibility to proper antenatal care and nonimplementation of both primary and secondary preventive modalities of congenital anomalies. [2228] In the current study, majority of the mothers of the affected children had primary or no formal education though most still opted for surgeries and other modalities of treatment as requested by the managing teams.…”

Section: Discussionmentioning

confidence: 90%

“…This is lower than the 2–3% reported in the general population[ 2 ] but compares favorably well with similar hospital based studies in Nigeria. [ 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

“…Current study reported myelomeningocele as the most common CNS anomaly in our study area as reported in other Nigerian hospital based studies. [ 22 23 31 ] However, earlier study in Enugu, South East Nigeria,[ 21 ] some three and half decades ago and in Ibadan, South West Nigeria,[ 24 ] respectively, reported hydrocephalus as the most common CNS anomaly. This shows a changing trend from higher incidence of hydrocephalus to neural tube defects – myelomeningocele.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: A retrospective study

et al. 2016

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Background:Congenital anomalies, including those of the central nervous system (CNS), are among the leading causes of morbidity, mortality, and fetal loss.Objective:To determine the prevalence and associated factors of CNS congenital anomalies in children.Methods:A cross-sectional retrospective study of children managed with CNS anomalies was undertaken. Relevant clinical data of identified cases based on standard case definitions were retrieved from their case record files. Data were analyzed using SPSS 20.0 while the level of statistical significance was set at P < 0.05.Results:Seventy-two cases of CNS anomalies were identified over the period under review; out of 7329 total pediatric admissions giving a prevalence of 0.98%. Spina bifida cystica, 49 (68.0%) was the most common of the five anomalies seen followed by congenital hydrocephalus 11 (15.3%). Fifty-seven (79.2%) of the mothers did not take periconceptional folic acid supplementation (P < 0.05) whereas 25 (34.7%), 6 (8.3%), and 1 (1.4%) reported history of febrile illness in the first trimester of pregnancy, alcohol use, and diabetes mellitus in pregnancy, respectively. Majority of the cases of spina bifida cystica (30 [61.2%]) seen had corrective surgeries while the overall case fatality rate was 1 (1.4%).Conclusions:Spina bifida cystica was the most common anomaly of the CNS seen in this study and majority of the mothers of affected children did not take periconceptional folic acid supplementation (P < 0.05). Efforts should be made to create awareness and apply adequate preventive health education models including the use of periconceptional folic acid supplementation as well as the provision of access to standard prenatal care to at risk mothers.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 90%

“…This is lower than the 2–3% reported in the general population[ 2 ] but compares favorably well with similar hospital based studies in Nigeria. [ 22 23 24 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: A retrospective study

et al. 2016

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“…Surveys all over the world have shown that the frequency of birth defects varies greatly from region to region and from country to country. A male preponderance was observed in our study population, there have been similar reports on this [13][14][15] whereas there has been report of equal sex distribution as well [16]. The reason for this sex variation cannot be explained and this could be by chance.…”

Section: Discussionsupporting

confidence: 77%

Congenital Central Nervous System Abnormalities in Bauchi, Nigeria: Our Experience in 4 Years

2023

MCMS

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Introduction: Congenital central nervous system abnormalities are among the leading cause of infant morbidity and mortality in developing countries. These abnormalities impair functions and cosmetic challenges among the survivors. We aimed to describe the pattern of the congenital CNS abnormalities in our environment. Materials and Methods:We carried out a retrospective study on children who presented and managed for congenital CNS abnormalities from October 2018 to September 2022. Clinical data of the patients were retrieved from their record files, admission record and operation notes. The data were analyzed and results expressed.Results: Two-hundred and thirteen children with congenital CNS abnormalities were reviewed within the study period. Congenital hydrocephalus (48%) was the most common abnormalities seen followed spinal bifida (27%). Forty-eight percent of the children presented after two month of life. Peri-conception folic acid intake/supplementation and febrile illness occurrence during first trimester of the pregnancy were reported as 15% and 29% of the mothers respectively. Conclusion: congenital hydrocephalus and spinal bifida are the most common congenital CNS abnormalities in our practice.Many of the mothers of the affected children did not have peri-conception folic acid intake or supplementation. Prevention, early detection during ante ante-natal care and early presentation at birth of the cases are needed efforts in our society.

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Major malformations of the Central Nervous System as seen at The University Teaching Hospital, Ilorin

Cited by 2 publications

References 0 publications

Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: A retrospective study

Epidemiology of congenital anomalies of the central nervous system in children in Enugu, Nigeria: A retrospective study

Congenital Central Nervous System Abnormalities in Bauchi, Nigeria: Our Experience in 4 Years

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